Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hung‐Jyun Huang"'
Autor:
Hung-Jyun Huang, 黃鴻鈞
92
Severe Acute Respiratory Syndrome (SARS) is caused by infection with a novel human coronavirus (SARS-CoV). We report herein the method developed to inhibit the main protease of SARS coronavirus. We used the core structure of a-hydroxy diethyl
Severe Acute Respiratory Syndrome (SARS) is caused by infection with a novel human coronavirus (SARS-CoV). We report herein the method developed to inhibit the main protease of SARS coronavirus. We used the core structure of a-hydroxy diethyl
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/46457774161930594548
Autor:
Hung-Jyun Huang, Win-Yin Wei, Shu Fu Lin, Shih-Hsien Chuang, Ying‐Shuen E. Lee, Chu-Bin Liao, Ching Yuh Chern, Jiann-Jyh Huang, Chun-Liang Lai, Ju-Ying Yang, Chao-Cheng Chiang, Yu-Hsiang Lin, Sheng-Chuan Yang, Chia-Wei Liu
Publikováno v:
Journal of the Chinese Chemical Society. 67:422-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d314c44815050554ea644ef35a43e201
https://doi.org/10.1002/jccs.201900466
https://doi.org/10.1002/jccs.201900466
Autor:
Li-Wei Teng, Mei-Hui Lee, Yu-Chuan Wang, Yu-Hsiang Lin, Ying-Shuan E. Lee, Sheng-Chuan Yang, Chao-Cheng Chiang, Shu Fu Lin, Shih-Hsien Chuang, Chia-Wei Liu, Jiann-Jyh Huang, Hung-Jyun Huang, Chun-Liang Lai, Ru-Wen Wang, Jia-Ming Chang, Win-Yin Wei, Ju-Ying Yang
Publikováno v:
RSC Adv.. 4:58990-58998
Pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones of scaffold 4 with various C-3′ side chains were designed as potent Met kinase inhibitors. Structural optimization led to compounds 10, 20, and 22–24 which demonstrated subnanomolar IC50 valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a338f8d3cc7061761706b64db95da6f
https://doi.org/10.1039/c4ra08720h
https://doi.org/10.1039/c4ra08720h
Publikováno v:
Tetrahedron. 67:927-935
This paper describes a convenient and efficient method for synthesizing chiral alcohol-substituted vinylogous urethanes, in which the double bond has E configuration was determined by single crystal X-ray analysis. In addition, we investigated the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c2f09f8baa3225653c6356c29a3d57
https://doi.org/10.1016/j.tet.2010.12.009
https://doi.org/10.1016/j.tet.2010.12.009
Autor:
Wen-Bin Yang, Hung-Jyun Huang
Publikováno v:
Tetrahedron Letters. 48:1429-1433
Moenocinol (C25H42O), the acyclic terpenoid unsaturated lipid part of moenomycin antibiotics, was prepared by an expedient method, which comprised organometallic reaction, Julia-Kocienski olefination, and enolate carbon bond formation as the key step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86cc74a29aa0a3c4fe8069a997bdb5c1
https://doi.org/10.1016/j.tetlet.2006.12.119
https://doi.org/10.1016/j.tetlet.2006.12.119
Autor:
Po-Huang Liang, Jim-Min Fang, Jia-Tsrong Jan, Hung-Jyun Huang, Yin-Ta Wu, Jiun-Jie Shie, Tun-Hsun Kuo, Yih-Shyun E. Cheng, Chi-Huey Wong, Chih-Jung Kuo
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract The dipeptide-conjugated ester derived from Phe-Phe dipeptide and 4-(dimethylamino)cinnamic acid shows a potent anti-SARS activity by inhibition of the 3CL protease.
The proteolytic processing of polyproteins by the 3CL protea
The proteolytic processing of polyproteins by the 3CL protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba831fdd0af8b70e13786b6f1611ba2d
https://doi.org/10.1016/j.bmc.2005.05.065
https://doi.org/10.1016/j.bmc.2005.05.065
Autor:
Yu-Kai Chen, Shao-Zheng Peng, Hung-Jyun Huang, Pan Yu-Chih, Jia-Ming Chang, Sian-Yi Ciou, Chen-Hsuan Ho, Chao-Pin Lee, Chu-Bin Liao
Publikováno v:
Cancer Research. 77:3206-3206
Tumor-associated macrophages (TAMs) are major components of leukocytic infiltrate of tumors. It has been reported that high TAMs density is associated with poor clinical prognosis. Within the tumor microenvironment, TAMs rely on signaling through CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca2ed2cfdc9b57c452ae07429e1c4cd
https://doi.org/10.1158/1538-7445.am2017-3206
https://doi.org/10.1158/1538-7445.am2017-3206
Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile
Autor:
Ju-Ying Yang, Shih-Hsien Chuang, Li-Wei Teng, Chia-Wei Liu, Wei Kuang Chi, Jia-Ming Chang, Ta-Tung Yuan, Chun-Liang Lai, Win-Yin Wei, Chu-Bin Liao, Chao-Cheng Chiang, Ru-Wen Wang, Paonien Chen, Hung-Jyun Huang, Yu-Hsiang Lin, Shu Fu Lin, Sheng-Chuan Yang, Ying-Shuen Lee, Jiann-Jyh Huang
Publikováno v:
Journal of medicinal chemistry. 53(16)
A series of pyrrole-indolin-2-ones were synthesized, and their inhibition profile for Aurora kinases was studied. The potent compound 33 with phenylsulfonamido at the C-5 position and a carboxyethyl group at the C-3' position selectively inhibited Au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499e5e36aadd6bb53dcc723ffcb3b783
https://pubmed.ncbi.nlm.nih.gov/20681538
https://pubmed.ncbi.nlm.nih.gov/20681538
Autor:
Hung‐Jyun Huang, Wen‐Bin Yang
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ad0883bf04f02bbcf71463bf8107101
https://doi.org/10.1002/chin.200722210
https://doi.org/10.1002/chin.200722210
Autor:
Jim-Min Fang, Chih-Jung Kuo, Chun-Hung Lin, Tun-Hsun Kuo, Yin-Ta Wu, Wen-Bin Yang, Hung-Jyun Huang, Jiun-Ling Chen, Chi-Huey Wong, Jiun-Jie Shie, Po-Huang Liang
Publikováno v:
Journal of medicinal chemistry. 48(13)
A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d5bd70eb212cad445fb9470c4370d9
https://pubmed.ncbi.nlm.nih.gov/15974598
https://pubmed.ncbi.nlm.nih.gov/15974598