Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure.

Autor: Melkonyan, Magda M.¹ magda.melkonyan@meduni.am, Hunanyan, Lilit¹, Lourhmati, Ali² ali.lourhmati@uni-tuebingen.de, Layer, Nikolas², Beer-Hammer, Sandra³ sandra.beer-hammer@uni-tuebingen.de, Yenkoyan, Konstantin⁴ konstantin.yenkoyan@meduni.am, Schwab, Matthias^2,5,6, Danielyan, Lusine² lusine.danielyan@med.uni-tuebingen.de

Publikováno v: International Journal of Molecular Sciences. Jan2018, Vol. 19 Issue 1, p9. 18p. 1 Diagram, 7 Graphs.

α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin

Autor: Schwinghammer, Ute A., Melkonyan, Magda M., Hunanyan, Lilit, Tremmel, Roman, Weiskirchen, Ralf, Borkham-Kamphorst, Erawan, Schaeffeler, Elke, Seferyan, Torgom, Mikulits, Wolfgang, Yenkoyan, Konstantin, Schwab, Matthias, Danielyan, Lusine

Publikováno v: Cells
Volume 9
Issue 2
Cells, Vol 9, Iss 2, p 456 (2020)
Cells 9(2), 456 (2020). doi:10.3390/cells9020456

The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver fibrosis. While &alpha
1- and &beta
adrenergic receptors (ARs) are suggested to be involved in a multitude of profibrogenic actions, little is known

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Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure.

Autor: Melkonyan MM; Department of Medical Chemistry, Yerevan state Medical University after M. Heratsi, 2 Koryun St., Yerevan 0025, Armenia. magda.melkonyan@meduni.am., Hunanyan L; Department of Medical Chemistry, Yerevan state Medical University after M. Heratsi, 2 Koryun St., Yerevan 0025, Armenia. h-lilit@live.com., Lourhmati A; Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. ali.lourhmati@uni-tuebingen.de., Layer N; Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. nikolas.layer@student.uni-tuebingen.de., Beer-Hammer S; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, Wilhelmstr. 56, D-72076 Tübingen, Germany. sandra.beer-hammer@uni-tuebingen.de., Yenkoyan K; Biochemistry Department, Yerevan state Medical University after M. Heratsi, 2 Koryun St., Yerevan 0025, Armenia. konstantin.yenkoyan@meduni.am., Schwab M; Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. matthias.schwab@ikp-stuttgart.de.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, Stuttgart, Auerbachstr. 112, D-70376 Stuttgart, Germany. matthias.schwab@ikp-stuttgart.de.; Department of Pharmacy and Biochemistry, University of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. matthias.schwab@ikp-stuttgart.de., Danielyan L; Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. lusine.danielyan@med.uni-tuebingen.de.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2017 Dec 21; Vol. 19 (1). Date of Electronic Publication: 2017 Dec 21.