Výsledky vyhledávání - "Hun Taek Kim"

Abstract 5090: TU2218, a dual inhibitor against ALK5/VEGFR2, increases anti-CTLA4 antitumor efficacy in syngeneic tumor models

Autor: Nam-Hoon Kim, Jihyun Lee, Hun-Taek Kim

Publikováno v: Cancer Research. 83:5090-5090

The combination of pembrolizumab with low-dose ipilimumab shows substantial antitumor activity and manageable profile of toxicity in anti-PD-(L)1 antibody failure-setting (NCT02743819). This suggests a breakthrough for the absence of treatment option

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbfbd52d3399d406229bb6d54652bfbe
https://doi.org/10.1158/1538-7445.am2023-5090

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Abstract 5080: TU2218, a novel ALK5/VEGFR2 dual inhibitor, overcomes tumor endothelial cell anergy and enhances anti-PD1 immunotherapy efficacy

Autor: Jihyun Lee, Nam-hoon Kim, Hun-Taek Kim

Publikováno v: Cancer Research. 83:5080-5080

Immune tolerance by TGF-β and VEGF is inextricably related with poor outcomes of approved anti-PD-(L)1 therapy. Accordingly, a dual target for ALK5 and VEGFR2 via single or combination treatments can be an unequivocal tactic to tune tumor-microenvir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fe7068c503e47e3720e165ae54086c5
https://doi.org/10.1158/1538-7445.am2023-5080

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Abstract 5538: Functional characterization of TU2218, ALK5 and VEGFR2 dual inhibitor, on in vitro tumor immunity-mimetic systems

Autor: Nam-Hoon Kim, Seong-Ho Kang, Jihyun Lee, Seung-Hyun Kim, Chan-Hee Yu, Jae Won Choi, Soyoun Ahn, Jeongmin Seo, Hun-Taek Kim

Publikováno v: Cancer Research. 82:5538-5538

High level of plasma TGF-β is significantly correlated with poor outcomes with approved immune-oncology therapeutics. Poor clinical results for ALK5 inhibitors and bifunctional fusion protein targeting TGF-β and PD-L1 are also being reported in sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7db376513d9314ae7d6d49b9694eeed
https://doi.org/10.1158/1538-7445.am2022-5538

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First-in-Human, Double-Blind, Randomized Controlled Trial of an Oral Dose of GnRH Antagonist TU2670 in Healthy Women

Autor: Sangmin Choe, Sungpil Han, Jae-Yoon Shim, Kyoung Soo Lim, Sang Heon Cho, Minhee Lee, Jaewoo Kim, Yong Soon Cho, Hun Taek Kim, Seon Mi Kim, Jin-Ah Jung, Hyeong Seok Lim, Sangkeun Choi, Kyun-Seop Bae, Seok Kyu Yoon, Jong Lyul Ghim

Publikováno v: The Journal of clinical endocrinology and metabolism. 106(3)

Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TU2670, a novel orally active, nonpeptide gonadotropin-releasing hormone (GnRH) antagonist administered to healthy female participants. Methods This was a first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17d301df5002c69c832ca4bc5f4781a
https://pubmed.ncbi.nlm.nih.gov/33347565

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Trends in the incidence rate of device-associated infections in intensive care units after the establishment of the Korean Nosocomial Infections Surveillance System

Autor: G.-R. Bae, Hun-Taek Kim, Su Ha Han, Tae Hyong Kim, Hyeonmi Yoo, Kyungwon Lee, Hyukjae Choi, Hee Kyung Chun, Hyunju Lee, Yee Gyung Kwak, D.W. Kim, Jae Seok Kim, Byung Wook Eun, Hyun-Sook Koo, Jun Yong Choi, Sung Ran Kim, Se-Whan Lee, Yongsun Kim

Publikováno v: Journal of Hospital Infection. 91:28-34

The effectiveness of continuous nationwide surveillance on healthcare-associated infections should be investigated in each country.To assess the rate of device-associated infections (DAIs) in intensive care units (ICUs) since the establishment of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01401d6258b8f88f78a74ccff10312f
https://doi.org/10.1016/j.jhin.2015.06.002

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Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy

Autor: George Stoica, Hun-Taek Kim, Gina Lungu, Paul K.Y. Wong

Publikováno v: Brain Research. 1208:204-216

The progressive spongiform encephalomyelopathy caused by ts1, a neuropathogenic temperature-sensitive mutant of Moloney murine leukemia virus (MoMuLV-ts1), results in motor neuronal loss without direct neuronal infection. We have previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d36cf12921334a7ed716883c28b9608
https://doi.org/10.1016/j.brainres.2008.02.085

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Five-year decreased incidence of surgical site infections following gastrectomy and prosthetic joint replacement surgery through active surveillance by the Korean Nosocomial Infection Surveillance System

Autor: Jae Seok Kim, Kyungwon Lee, J. D. Yoo, Yee Gyung Kwak, J. Sung, Hyun-Sook Koo, Tae Hyong Kim, Hyukjae Choi, Hee Kyung Chun, Sang-Oh Lee, Hun-Taek Kim, Sung Ran Kim, Hyeonmi Yoo, Hyukmin Lee, L. Adiyani, Su Ha Han, Jun Yong Choi, E. H. Cho, Yongsun Kim

Publikováno v: The Journal of hospital infection. 93(4)

Summary Background Surveillance of healthcare-associated infection has been associated with a reduction in surgical site infection (SSI). Aim To evaluate the Korean Nosocomial Infection Surveillance System (KONIS) in order to assess its effects on SS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0862cae97f54f42ca48f20ebddf7dc84
https://pubmed.ncbi.nlm.nih.gov/26944901

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Effect of SKI2670, a novel, orally active, non-peptide GnRH antagonist, on hypothalamic-pituitary-gonadal axis

Autor: Hun-Taek Kim, Taekyung Yoo, Jung-Hye Choi, Min Young Han, Eun Jeong Kim, Soo-Min Lee, Seung-Hyun Jung, So Young Lee, Seon-Mi Kim, Minhee Lee, Keun Ho Ryu

Publikováno v: Life sciences. 139

Aims Suppression of the hypothalamic–pituitary–gonadal axis has been widely utilized for the management of gonadal-hormone-dependent diseases such as endometriosis. Efforts to develop orally available gonadotropin-releasing hormone (GnRH) antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a43a97fa77148f7623fa5fba209e2bd
https://pubmed.ncbi.nlm.nih.gov/26321528

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