Výsledky vyhledávání - "Humphries ESA"

Akademický článek

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments.

Autor: Rapedius M; Nanion Technologies GmbH, Munich, Germany., Obergrussberger A; Nanion Technologies GmbH, Munich, Germany., Humphries ESA; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Scholz S; Nanion Technologies GmbH, Munich, Germany., Rinke-Weiss I; Nanion Technologies GmbH, Munich, Germany., Goetze TA; Nanion Technologies GmbH, Munich, Germany., Brinkwirth N; Nanion Technologies GmbH, Munich, Germany., Rotordam MG; Nanion Technologies GmbH, Munich, Germany., Strassmaier T; Nanion Technologies Inc., Livingston, NJ, United States., Randolph A; Nanion Technologies Inc., Livingston, NJ, United States., Friis S; Nanion Technologies GmbH, Munich, Germany., Liutkute A; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.; German Center for Cardiovascular Research, Partner Site Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells', University of Göttingen, Göttingen, Germany., Seibertz F; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.; German Center for Cardiovascular Research, Partner Site Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells', University of Göttingen, Göttingen, Germany., Voigt N; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.; German Center for Cardiovascular Research, Partner Site Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells', University of Göttingen, Göttingen, Germany., Fertig N; Nanion Technologies GmbH, Munich, Germany.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Aug 22; Vol. 15, pp. 982316. Date of Electronic Publication: 2022 Aug 22 (Print Publication: 2022).

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Calcium/calmodulin‐dependent kinase 2 mediates Epac‐induced spontaneous transient outward currents in rat vascular smooth muscle

Autor: Humphries, ESA, Kamishima, T, Quayle, JM, Dart, C

Publikováno v: The Journal of Physiology

Key points The Ca2+ and redox‐sensing enzyme Ca2+/calmodulin‐dependent kinase 2 (CaMKII) is a crucial and well‐established signalling molecule in the heart and brain. In vascular smooth muscle, which controls blood flow by contracting and relax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e2c1269ecbed04bd89a0b8a57e39198d

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Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.

Autor: Kramer J; Charles River Laboratories, Cleveland, OH, USA., Himmel HM; Safety Pharmacology, Bayer AG, Wuppertal, Germany., Lindqvist A; Sophion Bioscience A/S, Ballerup, Denmark., Stoelzle-Feix S; Nanion Technologies GmbH, Munich, Germany., Chaudhary KW; Global Safety Pharmacology, GlaxoSmithKline PLC, Collegeville, PA, USA., Li D; Drug Safety Research & Development, Pfizer, Groton, CT, USA., Bohme GA; Integrated Drug Discovery, High Content Biology Unit, Sanofi R&D, Vitry-Sur-Seine, France., Bridgland-Taylor M; Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, Astra Zeneca, Cambridge, UK., Hebeisen S; B'SYS GmbH, Witterswil, Switzerland., Fan J; Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, NJ, USA., Renganathan M; Eurofins Discovery, St. Charles, MO, USA., Imredy J; Merck & Co., Inc., Kenilworth, NJ, USA., Humphries ESA; Metrion Biosciences Ltd., Cambridge, UK., Brinkwirth N; Nanion Technologies GmbH, Munich, Germany., Strassmaier T; Nanion Technologies, Livingston, NJ, USA., Ohtsuki A; Nanion Technologies Japan K.K., Shinjyuku-ku, Tokyo, Japan., Danker T; Natural and Medical Science Institute at the University of Tübingen, Reutlingen, Germany., Vanoye C; Northwestern Feinberg School of Medicine, Chicago, IL, USA., Polonchuk L; Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Fermini B; Novoheart, Vancouver, BC, Canada., Pierson JB; Health and Environmental Sciences Institute, Washington, DC, USA. Jpierson@hesiglobal.org., Gintant G; AbbVie, Chicago, IL, USA.

Publikováno v: Scientific reports [Sci Rep] 2020 Jul 14; Vol. 10 (1), pp. 11884. Date of Electronic Publication: 2020 Jul 14.

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Akademický článek

Quantitative proteomics characterization of acutely isolated primary adult rat cardiomyocytes and fibroblasts.

Autor: Poulsen PC; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Schrölkamp M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Bagwan N; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Leurs U; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Humphries ESA; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Bomholzt SH; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Nielsen MS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Bentzen BH; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Olsen JV; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark., Lundby A; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. Electronic address: alicia.lundby@sund.ku.dk.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Jun; Vol. 143, pp. 63-70. Date of Electronic Publication: 2020 Apr 20.

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Akademický článek

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.

Publikováno v: Scientific reports [Sci Rep] 2020 Mar 27; Vol. 10 (1), pp. 5627. Date of Electronic Publication: 2020 Mar 27.

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Akademický článek

Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle.

Autor: Humphries ESA; Institutes of Integrative Biology., Kamishima T; Translational Medicine, University of Liverpool, Liverpool, UK., Quayle JM; Translational Medicine, University of Liverpool, Liverpool, UK., Dart C; Institutes of Integrative Biology.

Publikováno v: The Journal of physiology [J Physiol] 2017 Sep 15; Vol. 595 (18), pp. 6147-6164. Date of Electronic Publication: 2017 Aug 14.

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