Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Humphrey H.-C. Yao"'
Autor:
Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell ide
Externí odkaz:
https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14442 (2022)
Genetic alterations of the RUNX1 gene are associated with a variety of malignancies, including female-related cancers. The role of RUNX1 as either a tumor suppressor gene or an oncogene is tissue-dependent and varies based on the cancer type. Both th
Externí odkaz:
https://doaj.org/article/64568aa5da3f454cabd014564b18d5bd
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Single-cell RNA sequencing (scRNA-seq) technologies have precipitated the development of bioinformatic tools to reconstruct cell lineage specification and differentiation processes with single-cell precision. However, current start-up costs and recom
Externí odkaz:
https://doaj.org/article/b8399e03a0c443eeb0b381fff628dee8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventually share the same functions of producing oocytes and estrogens, ovarian differentiation relie
Externí odkaz:
https://doaj.org/article/4a69b4a6048141cc88dc7527081d8420
Autor:
Doan T Dinh, James Breen, Barbara Nicol, Natalie J Foot, David C Bersten, Alaknanda Emery, Kirsten M Smith, Ying Y Wong, Simon C Barry, Humphrey H C Yao, Rebecca L Robker, Darryl L Russell
Publikováno v:
Nucleic Acids Research.
Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, rapid acute induction of PGR is the key determinant of ovulation through transcriptional control of a unique set of genes
Publikováno v:
International journal of molecular sciences. 23(22)
Genetic alterations of the
Publikováno v:
Frontiers in Endocrinology. 13
In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation. Since then, our knowledge of androgen impacts on differentiation of the male internal (Wo
Publikováno v:
Biol Reprod
Development and functions of the ovary rely on appropriate signaling and communication between various ovarian cell types. FOXL2, a transcription factor that plays a key role at different stages of ovarian development, is associated with primary ovar
Publikováno v:
Reprod Toxicol
The flame retardant and plasticizer, tetrabromobisphenol-A (TBBPA) has rapidly become a common component in the manufacture of circuit boards and plastics worldwide. It is also an analog of bisphenol A (BPA), an endocrine disrupting chemical identifi
Autor:
Young-Min Kim, Humphrey H.-C. Yao, Minseok Seo, Hong Jo Lee, Soo Taek Han, Kyung Je Park, Kyung Min Jung, Kyu Hyuk Lee, Hee Jung Choi, Jin Se Park, Kyung Youn Lee, Jae Yong Han, Deivendran Rengaraj
Publikováno v:
FASEB J
Compared with the well-described XY sex determination system in mammals, the avian ZW sex determination system is poorly understood. Knockdown and overexpression studies identified doublesex and mab-3 related transcription factor 1 (DMRT1) as the tes