Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Humphrey F. Brugghe"'
Autor:
Peter Hoogerhout, Willem Kamphuis, Humphrey F Brugghe, Jacqueline A Sluijs, Hans A M Timmermans, Janny Westdijk, Gijsbert Zomer, Claire J P Boog, Elly M Hol, Germie P J M van den Dobbelsteen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19110 (2011)
The 39- to 42-residue amyloid β (Aβ) peptide is deposited in extracellular fibrillar plaques in the brain of patients suffering from Alzheimer's Disease (AD). Vaccination with these peptides seems to be a promising approach to reduce the plaque loa
Externí odkaz:
https://doaj.org/article/7791c9bbd1bf44848d903f4836db19d3
Autor:
Humphrey F. Brugghe, Wichard Tilstra, Peter Hoogerhout, Harry van Steeg, Janny Westdijk, Cornelis Kees Mulder, Ulrich L. M. Eisel, Yun Dong, Elly van Riet, Hans A. M. Timmermans
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer’s Disease, 52(3), 1111-1123. IOS Press
Journal of Alzheimer’s Disease, 52(3), 1111-1123. IOS Press
Background: Soluble oligomeric (misfolded) species of amyloid-beta (A beta) are the main mediators of toxicity in Alzheimer's disease (AD). These oligomers subsequently form aggregates of insoluble fibrils that precipitate as extracellular and periva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7ea0c2cae622bb6360db7a704cf15b
http://europepmc.org/articles/PMC4927839
http://europepmc.org/articles/PMC4927839
Autor:
Hans A. M. Timmermans, Leontine M. A. van Unen, Peter Hoogerhout, Jan Poolman, G. Jan ten Hove, Humphrey F. Brugghe, Gerrit van de Werken
Publikováno v:
International Journal of Peptide and Protein Research. 43:166-172
Starting from the alpha-(2,4-dimethoxybenzyl) ester of N-(9-fluorenylmethoxycarbonyl)aspartic acid [Fmoc-Asp-ODmb], side-chain-protected resin-bound Fmoc-peptides containing an N epsilon-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl lysyl [Lys(Dde)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea4d56972665e898a752ed18e457e04
https://doi.org/10.1111/j.1399-3011.1994.tb00518.x
https://doi.org/10.1111/j.1399-3011.1994.tb00518.x
Autor:
Jan ten Hove, Daan J.A. Crommelin, Peter Hoogerhout, Wim Jiskoot, Wim E. Hennink, Humphrey F. Brugghe, Ad L. De Jong, Gideon F.A. Kersten, Hugo D. Meiring, Bernard Metz, Hans A. M. Timmermans
Publikováno v:
Journal of Biological Chemistry. 279:6235-6243
Formaldehyde is a well known cross-linking agent that can inactivate, stabilize, or immobilize proteins. The purpose of this study was to map the chemical modifications occurring on each natural amino acid residue caused by formaldehyde. Therefore, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ab296284c2cdf1e03a226619625685
https://doi.org/10.1074/jbc.m310752200
https://doi.org/10.1074/jbc.m310752200
Autor:
Koert J. Stittelaar, Humphrey F. Brugghe, Paul Roholl, J. A M Timmermans, G J ten Hove, Jan H.G. Hoekman, Wim Jiskoot, Peter Hoogerhout
Publikováno v:
The Journal of Peptide Research. 54:436-443
The mechanism which enables lipopeptides to induce cytotoxicity is not known. By preparing fluorescent-labeled lipopeptides one might unravel the mechanism of their entry into the cell and their intracellular pathway. A method of preparing double-flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::757cefaa66f83663ae64ae44cffcff6d
https://doi.org/10.1034/j.1399-3011.1999.00128.x
https://doi.org/10.1034/j.1399-3011.1999.00128.x
Autor:
Peter Hoogerhout, Emmanuel J. H. J. Wiertz, Mark Achtman, Alexei A. Delvig, Hans A. M. Timmermans, L. M. A. Van Unen, E. M. L. M. Donders, Jan Poolman, Humphrey F. Brugghe
Publikováno v:
Europe PubMed Central
Former studies have shown that the class 5 outer membranes proteins (Opa and Opc proteins) of Neisseria meningitidis are at least as immunogenic as meningococcal porin proteins. High antibody titers to class 5 proteins have been observed in sera obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd41b5a0a96ee77bc48379b7dcfb4c41
https://doi.org/10.1128/iai.64.1.298-304.1996
https://doi.org/10.1128/iai.64.1.298-304.1996
Publikováno v:
Carbohydrate Research. 195:C1-C4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34c2f3a9aabca3f50b53b603336c8a8
https://doi.org/10.1016/0008-6215(90)84174-s
https://doi.org/10.1016/0008-6215(90)84174-s
Autor:
Ad P. J. M. de Jong, Claire J. P. Boog, Betsy Kuipers, Jacqueline A. M. van Gaans-van den Brink, Humphrey F. Brugghe, Gino J E Baart, Cécile A. C. M. van Els, Martien C. M. Poelen, Joost van Schie, Hans A. M. Timmermans, Hugo D. Meiring
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(9)
The meningococcal class I outer membrane protein porin A plays an important role in the development of T cell-dependent protective immunity against meningococcal serogroup B infection and is therefore a major component of candidate meningococcal vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391f475b5e5ed7433d6350ed344eef19
https://pubmed.ncbi.nlm.nih.gov/15843563
https://pubmed.ncbi.nlm.nih.gov/15843563
Autor:
Bernard, Metz, Gideon F A, Kersten, Peter, Hoogerhout, Humphrey F, Brugghe, Hans A M, Timmermans, Ad, de Jong, Hugo, Meiring, Jan, ten Hove, Wim E, Hennink, Daan J A, Crommelin, Wim, Jiskoot
Publikováno v:
The Journal of biological chemistry. 279(8)
Formaldehyde is a well known cross-linking agent that can inactivate, stabilize, or immobilize proteins. The purpose of this study was to map the chemical modifications occurring on each natural amino acid residue caused by formaldehyde. Therefore, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::090c7c570095412f15988fc2a6986247
https://pubmed.ncbi.nlm.nih.gov/14638685
https://pubmed.ncbi.nlm.nih.gov/14638685
Autor:
Robbert van der Most, Henny G. Otten, Peter Hoogerhout, Cécile A. C. M. van Els, Martien C. M. Poelen, Grada M. van Bleek, Hans A. M. Timmermans, Claire J. P. Boog, Humphrey F. Brugghe
Memory CD4 T-cell responses against respiratory syncytial virus (RSV) were evaluated in peripheral blood mononuclear cells of healthy blood donors with gamma interferon enzyme-linked immunospot (Elispot) assays. RSV-specific responses were detected i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee40fe6e213833b5289c143a049065fd
https://europepmc.org/articles/PMC140824/
https://europepmc.org/articles/PMC140824/
