A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs.

Autor: Condado-Morales I; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark.; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland., Dingfelder F; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark.; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland., Waibel I; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland., Turnbull OM; Department of Statistics, University of Oxford, Oxford, UK., Patel B; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland., Cao Z; Department of Bioanalysis, Beijing Novo Nordisk Pharmaceutical Science & Technology Co. Ltd (Novo Nordisk R&D China), Beijing, China., Rose Bjelke J; Department of Purification Technologies, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark., Nedergaard Grell S; Department of Kidney Biology, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark., Bennet A; Department of Kidney Biology, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark., Hummer AM; Department of Statistics, University of Oxford, Oxford, UK., Raybould MIJ; Department of Statistics, University of Oxford, Oxford, UK., Deane CM; Department of Statistics, University of Oxford, Oxford, UK., Egebjerg T; Department of Mammalian Expression, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark., Lorenzen N; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark., Arosio P; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland.

Publikováno v: MAbs [MAbs] 2024 Jan-Dec; Vol. 16 (1), pp. 2403156. Date of Electronic Publication: 2024 Oct 04.

Advances in computational structure-based antibody design.

Autor: Hummer AM; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, UK. Electronic address: https://twitter.com/@AlissaHummer., Abanades B; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, UK. Electronic address: https://twitter.com/@brennanaba., Deane CM; Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, UK. Electronic address: deane@stats.ox.ac.uk.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2022 Jun; Vol. 74, pp. 102379. Date of Electronic Publication: 2022 Apr 28.

Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.

Autor: Li D; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; School of Life Sciences, East China Normal University, Shanghai, China., Li N; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Zhang YF; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Fu H; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun, China., Feng M; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Schneider D; Lentingen, a Miltenyi Biotec Company, Gaithersburg, Maryland., Su L; Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick, Maryland., Wu X; Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick, Maryland., Zhou J; IsoPlexis Corporation, Branford, Connecticut., Mackay S; IsoPlexis Corporation, Branford, Connecticut., Kramer J; Animal Facility, Leidos Biomedical Research, Inc, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Duan Z; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Yang H; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Kolluri A; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Hummer AM; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Torres MB; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Zhu H; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland., Hall MD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland., Luo X; Collaborative Protein Technology Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Chen J; Collaborative Protein Technology Resource, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Wang Q; School of Life Sciences, East China Normal University, Shanghai, China., Abate-Daga D; Departments of Immunology, Cutaneous Oncology, and Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Dropulic B; Lentingen, a Miltenyi Biotec Company, Gaithersburg, Maryland., Hewitt SM; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Orentas RJ; Seattle Children's Research Institute, Seattle, Washington., Greten TF; Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ho M; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: homi@mail.nih.gov.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Jun; Vol. 158 (8), pp. 2250-2265.e20. Date of Electronic Publication: 2020 Feb 12.