Cardiac Dysfunction in Children and Young Adults Treated With MEK Inhibitors: A Retrospective, Single-Center Study.

Autor: Bender JD; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Pillay-Smiley N; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Hill GD; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., de Blank P; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Hummel TR; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Weiss BD; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Kumar A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Zang H; Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Ollberding NJ; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Ryan TD; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Publikováno v: JACC. CardioOncology [JACC CardioOncol] 2024 Aug 06; Vol. 6 (5), pp. 794-796. Date of Electronic Publication: 2024 Aug 06 (Print Publication: 2024).

Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report.

Autor: DeWire M; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Lazow M; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., Campagne O; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Leach J; Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Fuller C; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Senthil Kumar S; The Ohio State University College of Medicine, Columbus, Ohio, USA., Stanek J; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., de Blank P; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Hummel TR; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Pillay-Smiley N; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Salloum R; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., Stevenson CB; Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Baxter P; Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA., Gass D; Cancer and Blood Disorders Department, Atrium Health Levine Children's Hospital, Charlotte, North Carolina, USA., Goldman S; Phoenix Children's Hospital, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA., Leary SES; Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA., Carle A; Anderson Center Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Mikael L; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., Crabtree D; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., Chaney B; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA., Lane A; Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Drissi R; The Ohio State University College of Medicine, Columbus, Ohio, USA., Stewart CF; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Fouladi M; Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2022 Apr 16; Vol. 4 (1), pp. vdac055. Date of Electronic Publication: 2022 Apr 16 (Print Publication: 2022).

Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers.

Autor: DeWire M; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA. Mariko.dewire@cchmc.org., Erker C; Division of Hematology/Oncology, Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada., Hummel TR; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Chow LML; Department of Hematology/Oncology, Dayton Children's Hospital, Dayton, OH, USA., de Blank P; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Salloum R; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Pillay-Smiley N; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Hoffman L; Department of Hematology/Oncology, Phoenix Children's Hospital, Phoenix, AZ, USA., Gilger E; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Gallagher M; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Driver L; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Meister D; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Ward H; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Drissi R; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.; Center for Childhood Cancer & Blood Disorders, Nationwide Children's Hospital, Columbus, OH and The Ohio State University College of Medicine, Columbus, OH, USA., Kumar SS; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.; Center for Childhood Cancer & Blood Disorders, Nationwide Children's Hospital, Columbus, OH, USA., Sengupta S; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.; Division of Research, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA., Kikta B; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Meriwether W; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Jelinek S; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Asher A; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Jones B; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Leach J; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Miles L; Department of Pathology and Laboratory Medicine, Nemours Children's Health System, Orlando, FL, USA., Fuller C; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Fouladi M; Division of Oncology, Department of Pediatrics College of Medicine, Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.; Hematology/Oncology &, BMT, Nationwide Children's Hospital, The Ohio State University College of Medicine, ColumbusColumbus, OHOH, USA.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2021 Mar; Vol. 152 (1), pp. 107-114. Date of Electronic Publication: 2021 Jan 27.

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas.

Autor: Lazow MA; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA., Hoffman L; Department of Oncology, Phoenix Children's Hospital, Phoenix, AZ, USA., Schafer A; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA., Osorio DS; Department of Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Boué DR; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Rush S; Department of Oncology, Akron Children's Hospital, Akron, OH, USA., Wright E; Department of Oncology, Akron Children's Hospital, Akron, OH, USA., Lane A; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., DeWire-Schottmiller MD; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Smolarek T; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Sipple J; Department of Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Taggert H; Department of Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Reuss J; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA., Salloum R; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hummel TR; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., de Blank P; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Pillay-Smiley N; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Sutton ME; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Asher A; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA., Stevenson CB; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Drissi R; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Finlay JL; Department of Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Fouladi M; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA. maryam.fouladi@nationwidechildrens.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. maryam.fouladi@nationwidechildrens.org.; Pediatric Neuro-Oncology, Nationwide Children's Hospital, 700 Children's Dr., Columbus, OH, 43205, USA. maryam.fouladi@nationwidechildrens.org., Fuller C; Brain Tumor Center, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA. fullerch@upstate.edu.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. fullerch@upstate.edu.; Department of Pathology, Upstate Medical University, 750 E Adams St., Syracuse, NY, 13210, USA. fullerch@upstate.edu.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Nov 05; Vol. 8 (1), pp. 182. Date of Electronic Publication: 2020 Nov 05.

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors.

Autor: Kieran MW; Harvard Medical School, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Geoerger B; Department of Childhood and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France. birgit.geoerger@gustaveroussy.fr., Dunkel IJ; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York., Broniscer A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Hargrave D; UCL Great Ormond Street Institute of Child Health, Pediatric Oncology Unit, London, United Kingdom., Hingorani P; Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona., Aerts I; Institut Curie, PSL Research University, Oncology Center SIREDO, Paris, France., Bertozzi AI; CHU de Toulouse - Pôle Pédiatrique, Toulouse, France., Cohen KJ; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Hummel TR; Cancer and Blood Disorder Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Shen V; Children's Hospital of Orange County, Orange, California., Bouffet E; The Hospital for Sick Children, University of Toronto, Department of Pediatrics, Toronto, Ontario., Pratilas CA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Pearson ADJ; Paediatric Drug Development, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, and The Institute of Cancer Research, Sutton, United Kingdom., Tseng L; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey., Nebot N; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey., Green S; Novartis Pharma AG, Basel, Switzerland., Russo MW; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey., Whitlock JA; The Hospital for Sick Children, University of Toronto, Department of Pediatrics, Toronto, Ontario.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Dec 15; Vol. 25 (24), pp. 7294-7302. Date of Electronic Publication: 2019 Sep 10.