Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity.

Autor: Backenroth D; Janssen Research & Development, Titusville, USA., Royce T; Flatiron Health, Inc, 233 Spring Street, New York, NY, 10013, USA., Pinheiro J; Janssen Research & Development, Titusville, USA., Samant M; Flatiron Health, Inc, 233 Spring Street, New York, NY, 10013, USA., Humblet O; Flatiron Health, Inc, 233 Spring Street, New York, NY, 10013, USA. ohumblet@gmail.com.

Publikováno v: BMC medical research methodology [BMC Med Res Methodol] 2023 Aug 24; Vol. 23 (1), pp. 193. Date of Electronic Publication: 2023 Aug 24.

Real-world survival outcomes in patients with locally advanced or metastatic NTRK fusion-positive solid tumors receiving standard-of-care therapies other than targeted TRK inhibitors.

Autor: Hibar DP; Personalized Healthcare Analytics, Genentech, Inc., South San Francisco, California, United States of America., Demetri GD; Dana-Farber Cancer Institute and Ludwig Center at Harvard Medical School, Boston, Massachusetts, United States of America., Peters S; Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland., Davies J; Personalized Healthcare Data Science, Roche Products Ltd, Welwyn Garden City, United Kingdom., Humblet O; Quantitative Sciences, Flatiron Health Inc., New York, New York, United States of America., Maund SL; Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America., Perez L; Personalized Healthcare Data Science, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Publikováno v: PloS one [PLoS One] 2022 Aug 08; Vol. 17 (8), pp. e0270571. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).

PCN198 Statistical Methods for Pantumor Analysis: Models to Account for Tumor-Level Heterogeneity

Autor: Swaminathan, A. ¹, Snider, J. ², Sondhi, A. ², Samant, M. ², Humblet, O. ²

Publikováno v: In Value in Health June 2021 24 Supplement 1:S56-S56

Bayesian additional evidence for decision making under small sample uncertainty.

Autor: Sondhi A; Flatiron Health, Inc., 233 Spring St, New York, NY, 10013, USA. arjun.sondhi@flatiron.com., Segal B; Flatiron Health, Inc., 233 Spring St, New York, NY, 10013, USA.; Present affiliation: Indigo Ag, Boston, MA, 02129, USA., Snider J; Flatiron Health, Inc., 233 Spring St, New York, NY, 10013, USA., Humblet O; Flatiron Health, Inc., 233 Spring St, New York, NY, 10013, USA., McCusker M; Flatiron Health, Inc., 233 Spring St, New York, NY, 10013, USA.; Present affiliation: GRAIL, Inc., Menlo Park, CA, 94025, USA.

Publikováno v: BMC medical research methodology [BMC Med Res Methodol] 2021 Oct 25; Vol. 21 (1), pp. 221. Date of Electronic Publication: 2021 Oct 25.

External comparator studies and the joint application of the estimand and target trial emulation frameworks.

Autor: Rippin, Gerd¹ (AUTHOR) gerd.rippin@iqvia.com, Sanz, Héctor² (AUTHOR)

Publikováno v: Frontiers in Drug Safety & Regulation. 2024, p1-7. 7p.