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Autor:
Frawley, Rachel P. *, Witt, Kristine L., Cunny, Helen, Germolec, Dori R., Jackson-Humbles, Daven, Malarkey, David, Shockley, Keith R., Stout, Matthew, Travlos, Greg, Buccellato, Matthew, Fallacara, Dawn, Harris, Shawn, Kissling, Grace E., Manheng, Wimolnut, Surh, Irene Inok, White, Kimber, Jr., Auerbach, Scott S.
Publikováno v:
In Toxicology August 2020 441
Autor:
Rania Dagher, Alan M. Copenhaver, Valerie Besnard, Aaron Berlin, Fatima Hamidi, Marielle Maret, Jingya Wang, Xiaotao Qu, Yashaswi Shrestha, Jincheng Wu, Gregory Gautier, Rajiv Raja, Michel Aubier, Roland Kolbeck, Alison A. Humbles, Marina Pretolani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 an
Externí odkaz:
https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa3
Autor:
Rania Dagher, Paul Fogel, Jingya Wang, David Soussan, Chia-Chien Chiang, Jennifer Kearley, Daniel Muthas, Camille Taillé, Patrick Berger, Arnaud Bourdin, Cécile Chenivesse, Sylvie Leroy, Gary Anderson, Alison A Humbles, Michel Aubier, Roland Kolbeck, Marina Pretolani, COBRA Consortium
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0277357 (2022)
ObjectiveNovel biomarkers related to main clinical hallmarks of Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder with pulmonary and extra-pulmonary manifestations, were investigated by profiling the serum levels of 1305 proteins
Externí odkaz:
https://doaj.org/article/cd31d45755914053bfce947e3f8d0404
Autor:
Humbles, Payal, Band, Molly E.
Publikováno v:
In Physician Assistant Clinics April 2019 4(2):477-485
Autor:
Keith R. Shockley, Michelle C. Cora, David E. Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J. Collins, Esra Mutlu, Veronica G. Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K. Dunnick
Publikováno v:
Data in Brief, Vol 32, Iss , Pp 106136- (2020)
Large-scale gene expression analysis of legacy* and emerging** brominated flame retardants were conducted in the male Harlan Sprague Dawley rat [1]. Each animal was dosed for 5 days with the chemical at concentrations of 0.1 – 1000 μmol/kg body we
Externí odkaz:
https://doaj.org/article/ef6e90cf26774df69f25a85f539a8103
Autor:
Rodrigo Jiménez-Saiz, Varun C. Anipindi, Heather Galipeau, Yosef Ellenbogen, Roopali Chaudhary, Joshua F. Koenig, Melissa E. Gordon, Tina D. Walker, Talveer S. Mandur, Soumeya Abed, Alison Humbles, Derek K. Chu, Jonas Erjefält, Kjetil Ask, Elena F. Verdú, Manel Jordana
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Eosinophils have emerged as multifaceted cells that contribute to tissue homeostasis. However, the impact of the microbiota on their frequency and function at mucosal sites remains unclear. Here, we investigated the role of the microbiota in the regu
Externí odkaz:
https://doaj.org/article/5103ca5ce415466b80ee467924a56408
Autor:
Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
The interleukin-1 family member IL-33 participates in both innate and adaptive T helper-2 immune cell responses in models of lung disease. The IL-6-type cytokine Oncostatin M (OSM) elevates lung inflammation, Th2-skewed cytokines, alternatively activ
Externí odkaz:
https://doaj.org/article/13b27e8ec6de4da39d57ceafb167da4f
Autor:
Arianna L. Smith, Emmanuel Paul, Devin McGee, Ranuka Sinniah, Emily Flom, Devan Jackson-Humbles, Jack Harkema, Karen E. Racicot
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Allergic asthma is a chronic pulmonary disorder fundamentally linked to immune dysfunction. Since the immune system begins developing in utero, prenatal exposures can affect immune programming and increase risk for diseases such as allergic asthma. C
Externí odkaz:
https://doaj.org/article/e636ab75bf604f85b92069817527bb2b
Autor:
Humbles, Alison A., Lloyd, Clare M., McMillan, Sarah J., Friend, Daniel S., Xanthou, Georgina, Ghiran, Sorina, Gerard, Norma P., Yu, Channing, Orkin, Stuart H., Gerard, Craig
Publikováno v:
Science, 2004 Sep . 305(5691), 1776-1779.
Externí odkaz:
https://www.jstor.org/stable/3837771