Clinical investigation of intestinal fatty acid-binding protein (I-FABP) as a biomarker of SARS-CoV-2 infection

Autor: Rafael Simone Saia, Humberto Giusti, Fábio Luis-Silva, Karina de Jesus Bonicenha Pedroso, Maria Auxiliadora-Martins, Karen Mirna Loro Morejón, Augusto Marcussi Degiovani, Márcia Regina Cadelca, Anibal Basile-Filho

Publikováno v: International Journal of Infectious Diseases, Vol 113, Iss , Pp 82-86 (2021)

ABSTRACT: Objectives: SARS-CoV-2 exhibits tropism for the gastrointestinal tract; however, lesions in enterocytes and their correlation with disease severity and patient prognosis are still unknown. Methods: SARS-CoV-2 patients were enrolled in 5 med

Externí odkaz: https://doaj.org/article/3a1dc91b23794da7858a56628dd3ee0a

Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain.

Autor: Érica Maria Granjeiro, Glauber S F da Silva, Humberto Giusti, José Antonio Oliveira, Mogens Lesner Glass, Norberto Garcia-Cairasco

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154141 (2016)

INTRODUCTION:We investigated the behavioral, respiratory, and thermoregulatory responses elicited by acute exposure to both hypercapnic and hypoxic environments in Wistar audiogenic rats (WARs). The WAR strain represents a genetic animal model of epi

Externí odkaz: https://doaj.org/article/539624024c3647ee933fd923c05f16ba

Cholecystokinin Modulates the Mucosal Inflammatory Response and Prevents the Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction

Autor: Rafael Simone Saia, Aline Barbosa Ribeiro, Humberto Giusti

Publikováno v: Shock (Augusta, Ga.). 53(2)

The intestinal mucosa plays a critical role in the organism, acting as an interface between the lamina propria and the harmful antigens in the lumen. Sepsis is associated with primary injury to the intestinal mucosa, which in turn induces bacterial t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0094cb99a7d2163819bf8e85e2c55ff0
https://pubmed.ncbi.nlm.nih.gov/30998649

Dexamethasone Prevents Lipopolysaccharide-Induced Epithelial Barrier Dysfunction in Rat Ileum

Autor: Aline Barbosa Ribeiro, Rafael Simone Saia, Humberto Giusti, Ana Paula Trevelin Souza, Celso Rodrigues Franci

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Inflammatory mediators have been postulated as elementary inducing factors to the disruption of the intestinal tight junctions (TJ) and consequently, gut permeability and bacterial translocation. Corticosteroids are considered the mainstay in the tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4881f83f44fae9c19cc3d0155a76ad
https://pubmed.ncbi.nlm.nih.gov/28650927

Hemodynamic and ventilatory response to different levels of hypoxia and hypercapnia in carotid body-denervated rats

Autor: Rubens Fazan, Helio Cesar Salgado, Mogens L. Glass, Humberto Giusti, Mauro de Oliveira, João Paulo J. Sabino

Publikováno v: Clinics
Clinics; v. 68 n. 3 (2013); 395-399
Clinics; Vol. 68 Núm. 3 (2013); 395-399
Clinics; Vol. 68 No. 3 (2013); 395-399
Universidade de São Paulo (USP)
instacron:USP
Clinics, Vol 68, Iss 3, Pp 395-399 (2013)
Clinics, Volume: 68, Issue: 3, Pages: 395-399, Published: 2013

OBJECTIVE: Chemoreceptors play an important role in the autonomic modulation of circulatory and ventilatory responses to changes in arterial O2 and/or CO2. However, studies evaluating hemodynamic responses to hypoxia and hypercapnia in rats have show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a985f39b5166dfd427b5347cb107343c
https://doi.org/10.6061/clinics/2013(03)oa18