Výsledky vyhledávání - "Humberto Fariñas"

Pharmacogenetic research activity in Central America and the Caribbean: a systematic review

Autor: María de los A Campos, Jorge Duconge, M.E.G. Naranjo, Carolina Céspedes-Garro, Hilda Roblejo, Lazara K Montané-Jaime, Humberto Fariñas, Eva M Peñas-Lledó, Ronald Ramírez, Carmen I. Villagrán, Fernanda Rodrigues-Soares, Víctor Serrano, Adrián LLerena

Publikováno v: Pharmacogenomics. 17:1707-1724

Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in Central America and the Caribbean. Materials & methods: A literature search for pharmacogenetic studies in each country of the region was conducted on three dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2db0e457debefe308104534939f2553
https://doi.org/10.2217/pgs-2016-0053

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Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach

Autor: Enrique Teran, Adrián LLerena, Marcela Bovera, Humberto Fariñas, Fernando de Andrés, Santiago Terán

Publikováno v: OMICS: A Journal of Integrative Biology. 20:88-96

Phenotyping of the CYP450 enzyme activities contributes to personalized medicine, but the past phenotyping approaches have followed a piecemeal strategy measuring single enzyme activities in vivo. A barrier to phenotyping of populations in rural and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ef88beef68aa1abe11facd551baa24
https://doi.org/10.1089/omi.2015.0131

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Relevancia de la ancestría para la variabilidad de polimorfismos de las enzimas metabolizadoras de fármacos CYP2C9, CYP2C19 y CYP2D6 en una población multiétnica de Costa Rica

Autor: Angélica Rocío Borbón Orjuela, Humberto Fariñas, ROCIO ORTIZ-LOPEZ, Marisol López-López, Adrián LLerena, Eduardo Tarazona, Fernanda Rodrigues-Soares, Ingrid Fricke-Galindo, NANCY MONROY-JARAMILLO, AUGUSTO ROJAS-MARTINEZ, Enrique Teran

Publikováno v: Revista de Biología Tropical, Volume: 64, Issue: 3, Pages: 1067-1076, Published: SEP 2016
Revista de Biología Tropical; Vol. 64 No. 3 (2016): Volume 64 – Regular number 3 – September 2016
Revista de Biología Tropical; Vol. 64 Núm. 3 (2016): Volumen 64 – Número regular 3 – Setiembre 2016
Revista Biología Tropical; Vol. 64 N.º 3 (2016): Volumen 64 – Número regular 3 – Setiembre 2016
Portal de Revistas UCR
Universidad de Costa Rica
instacron:UCR

CYP2C9, CYP2C19 and CYP2D6 metabolize around 40 % of drugs and their genes vary across populations. The Costa Rican population has a trihybrid ancestry and its key geographic location turns it into a suitable scenario to evaluate interethnic differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac2f997fb8e1cb1ebe3de5c553ac31d
http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77442016000301067&lng=en&tlng=en

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Inadequate iodine nutrition of pregnant women from Extremadura (Spain)

Autor: Gabriella Morreale de Escobar, Humberto Fariñas-Seijas, Javier Sánchez-Vega, Francisco Escobar del Rey

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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7 pages, 4 figures, 3 tables.
[Objective]: To evaluate the iodine nutrition of the pregnant women of the Spanish Autonomous Community Extremadura. There are approximately 10,000 births per year in Extremadura, which historically contains areas w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ccdc232d2ddb872d6762f47829a230
https://doi.org/10.1530/eje-08-0309

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Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes

Autor: Eva M Peñas-Lledó, Ingrid Fricke-Galindo, Humberto Fariñas, Marisol López-López, Fernando de Andrés, María Eugenia G Naranjo, Carolina Céspedes-Garro, Fernanda Rodrigues-Soares, Adrián LLerena

Publikováno v: Expert opinion on drug metabolismtoxicology. 11(12)

Notably differences in CYP2C9 allele frequencies among worldwide populations have been reported, with an interesting low frequency of the CYP2C9*2 allele in Amerindians compared with Admixed and European populations.Literature was searched using the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b9944d479def212dbcef8f40beb23
https://pubmed.ncbi.nlm.nih.gov/26595139

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Pharmacogenetics in Central American healthy volunteers: interethnic variability

Autor: M.E.G. Naranjo, Carolina Céspedes-Garro, Adrián LLerena, Ronald Ramírez, Ramiro Barrantes, Víctor Serrano, Pharmacogenomics Ribef, Humberto Fariñas

Publikováno v: Drug Metabolism and Personalized Therapy. 30

Ethnicity is one of the major factors involved in interindividual variability to drug response. This study aims to describe the frequency of the most relevant pharmacogenetic biomarkers and metabolic phenotypes in Central American healthy volunteers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e29b9620ae1e5b9c7a1dcb23eea19c
https://doi.org/10.1515/dmdi-2014-0025

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Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations

Autor: Eva M Peñas-Lledó, Humberto Fariñas, Adrián LLerena, Fernanda Rodrigues-Soares, María Eugenia G Naranjo, Eduardo Tarazona-Santos

Publikováno v: Expert opinion on drug metabolismtoxicology. 10(11)

The frequency of CYP2D6 alleles, related to either a lack of or increased enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM), can vary across ethnic groups and hence across geographic regions.Worldwide original r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed90e5d207031717272e849c636c7ec1
https://pubmed.ncbi.nlm.nih.gov/25316321

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