Výsledky vyhledávání - "Humberto Doriguêtto Gravina"

Akademický článek

Neutrophil paralysis in Plasmodium vivax malaria.

Autor: Fabiana Maria de Souza Leoratti, Silvia Cellone Trevelin, Fernando Queiroz Cunha, Bruno Coelho Rocha, Pedro Augusto Carvalho Costa, Humberto Doriguêtto Gravina, Mauro Shugiro Tada, Dhelio Batista Pereira, Douglas Taylor Golenbock, Lis Ribeiro do Valle Antonelli, Ricardo T Gazzinelli

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1710 (2012)

BACKGROUND:The activation of innate immune responses by Plasmodium vivax results in activation of effector cells and an excessive production of pro-inflammatory cytokines that may culminate in deleterious effects. Here, we examined the activation and

Externí odkaz: https://doaj.org/article/79837094175c4ecb9ae56910053fc299

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Upregulation of p38 pathway accelerates proliferation and migration of MDA-MB-231 breast cancer cells

Autor: Maria Elena de Lima, Jarbas M. Resende, Humberto Doriguêtto Gravina, Hugo W. Huth, Daniel Moreira dos Santos, Catherine Ropert, Alfredo M. Goes

Publikováno v: Oncology reports. 37(4)

Tumor cells capture the signaling pathways used by normal tissue to promote their own survival and dissemination and among them, the NF-κB and MAPK pathways (ERK, JNK and p38). MAPK activation has ambiguous effects on tumor cell fate depending on ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fb465a1d2a907b40ae07c30b7e01c3
https://pubmed.ncbi.nlm.nih.gov/28260101

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MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6CloTLR2hi but Not by Ly6ChiTLR2hi Monocytes during Trypanosoma cruzi Infection

Autor: Silvane M. F. Murta, Alfredo M. Goes, Humberto Doriguêtto Gravina, Catherine Ropert

Publikováno v: The Journal of biological chemistry. 291(45)

This study continues to explore the plasticity of Toll-like receptor 2 (TLR2) previously described in immune response during Trypanosoma cruzi infection. Here, we have shown that Ly6ChiTLR2hi monocytes were involved in TNF-α and IL-12 production, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863cd5b3665d9a1b49e05e6b7c8f5395
https://pubmed.ncbi.nlm.nih.gov/27646001

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Akademický článek

COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control

Autor: Mateus da Silva Matias Antunes, Fabricia Heloisa Cavicchioli Sugiyama, Humberto Doriguetto Gravina, Ricardo Cardoso Castro, Francisco Javier Romero Mercado, Julia Oliveira de Lima, Caroline Fontanari, Fabiani Gai Frantz

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

BackgroundTrained immunity is the enhanced innate immune response resulting from exposure to pathogens or vaccines against an unrelated pathogen stimulus. Certain vaccines induce a memory like response in monocytes and NK cells, leading to modulation

Externí odkaz: https://doaj.org/article/196db6c0cf07442d942b9752431942b8

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DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14 + CD16 + CD64 high CD32 low Inflammatory Monocytes from Malaria Patients

Autor: Isabella C. Hirako, Ricardo T. Gazzinelli, Humberto Doriguêtto Gravina, Marco Antonio Ataide, Betty Diamond, Dhelio Batista Pereira, Douglas T. Golenbock, Rosane B. de Oliveira, Warrison A. Andrade, Bruno Coelho Rocha, Joseph M. Vinetz, Sanjay Ram, Carolina Gallego-Marin

Publikováno v: mBio. 6

High levels of circulating immunocomplexes (ICs) are found in patients with either infectious or sterile inflammation. We report that patients with either Plasmodium falciparum or Plasmodium vivax malaria have increased levels of circulating anti-DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::415f7dac24ddac89f83237676c9129bf
https://doi.org/10.1128/mbio.01605-15

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Utilização diferencial dos TLR2 e TLR9 pelas células do eixo fagocítico mononuclear durante a infecção aguda por T. cruzi

Autor: Humberto Doriguêtto Gravina

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Este trabalho destaca o uso diferencia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::2cbba7d4d3ee0a9c16856aea18699918

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Akademický článek

Phenotypical Screening of an MMV Open Box Library and Identification of Compounds with Antiviral Activity against St. Louis Encephalitis Virus

Autor: Giuliana Eboli Sotorilli, Humberto Doriguetto Gravina, Ana Carolina de Carvalho, Jacqueline Farinha Shimizu, Marina Alves Fontoura, Talita Diniz Melo-Hanchuk, Artur Torres Cordeiro, Rafael Elias Marques

Publikováno v: Viruses, Vol 15, Iss 12, p 2416 (2023)

St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne Flavivirus that may cause severe neurological disease in humans and other animals. There are no specific treatments against SLEV infection or disease approved for human use, and drug r

Externí odkaz: https://doaj.org/article/c234a3b208bc4d74b360b91207ddd778

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Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi

Autor: Humberto Doriguêtto Gravina, Lis Ribeiro do Valle Antonelli, Ricardo T. Gazzinelli, Catherine Ropert

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63100 (2013)
PLoS ONE

Pathogens express ligands for several TLRs that may play a role in the induction or control of the inflammatory response during infection. Concerning Trypanosoma cruzi, the agent of Chagas disease, we have previously characterized glycosylphosphatidy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b514047683b4de2e6224ceb1f10691
http://europepmc.org/articles/PMC3641106?pdf=render

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In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

Autor: Márcia Rogéria de Almeida, Juliana Lopes Rangel Fietto, T.T. Oliveira, Natália Filardi Tafuri, Humberto Doriguêtto Gravina, A. Silva Júnior, Marisa Alves Nogueira Diaz

Publikováno v: Research in veterinary science. 91(3)

The antiviral activity of quercetin, morin and trans-cinnamic acid was evaluated in vitro against equid herpesvirus 1 (EHV-1) by determining the virucidal activity and using the time of addition assay to test inhibition of the viral replication cycle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013f46b117e82e269984f49a0a68bfe
https://pubmed.ncbi.nlm.nih.gov/21159355

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Neutrophil Paralysis in Plasmodium vivax Malaria

Autor: Douglas T. Golenbock, Humberto Doriguêtto Gravina, Bruno Coelho Rocha, Dhelio Batista Pereira, Lis Ribeiro do Valle Antonelli, Fabiana M. S. Leoratti, Ricardo T. Gazzinelli, Pedro A C Costa, Mauro Shugiro Tada, Silvia Cellone Trevelin, Fernando Q. Cunha

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1710 (2012)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases

Background The activation of innate immune responses by Plasmodium vivax results in activation of effector cells and an excessive production of pro-inflammatory cytokines that may culminate in deleterious effects. Here, we examined the activation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472d1f3c2b2ba8c25eacfded1be9e4db
https://doi.org/10.1371/journal.pntd.0001710

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