Zobrazeno 1 - 10
of 2 757
pro vyhledávání: '"Humanized Mice"'
Autor:
Husheem Michael, Gene W. Weng, Mikaela M. Vallas, Douglas Lovos, Ellen Chen, Paul Sheiffele, Wei Weng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Gamma delta (γδ) T cells, which reside in mucosal and epithelial tissues, are integral to immune responses and are involved in various cancers, autoimmune, and infectious diseases. To study human γδ T cells to a translational level, we d
Externí odkaz:
https://doaj.org/article/020ca796f2584d5c84d29fb2772d14ef
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Nonhuman primate (NHP) models employing simian/simian-human immunodeficiency viruses (SIV/SHIVs) played a major role in the study of HIV pathogenesis, latency, and cure studies in a preclinical setting. However, it took many years to arrive at the cu
Externí odkaz:
https://doaj.org/article/c54ab7260e214d348a6cbaec5428adc0
Autor:
Bo He, Larissa Dymond, Kira H. Wood, Edward R. Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M. Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C. Ee, Scott W. White, Louise Winteringham, Ruth Ganss
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Gastrointestinal stromal tumors (GISTs) harbor diverse immune cell populations but so far immunotherapy in patients has been disappointing. Here, we established cord blood humanized mouse models of localized and disseminated GIST to explore the remod
Externí odkaz:
https://doaj.org/article/5f92efd8788044f3a874c385746f567f
Autor:
Yongzhen Liu, Stephanie Maya, Sebastian Carver, Aoife K. O’Connell, Anna E. Tseng, Hans P. Gertje, Kathleen Seneca, Ronald G. Nahass, Nicholas A. Crossland, Alexander Ploss
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Hepatitis B virus (HBV) infection remains a major public health problem and, in associated co-infection with hepatitis delta virus (HDV), causes the most severe viral hepatitis and accelerated liver disease progression. As a defective satellite RNA v
Externí odkaz:
https://doaj.org/article/b3f1e5ed3cf34095926b0a10f4fa94cc
Autor:
Luca Baroncini, Christina K. S. Muller, Nicole P. Kadzioch, Rebekka Wolfensberger, Doris Russenberger, Simon Bredl, Tafadzwa Mlambo, Roberto F. Speck
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionVery little is known about the role of macrophages as immune mediators during natural HIV infection. Humanized mice are an extremely valuable in vivo model for studying HIV pathogenesis. However, the presence of murine mononuclear phagocy
Externí odkaz:
https://doaj.org/article/06401074fb03470592dda5711981635e
Autor:
Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L. Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J. Cotler, Shiro Oka, Kazuaki Chayama, Harel Dahari
Publikováno v:
Virus Research, Vol 349, Iss , Pp 199451- (2024)
Recent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ a
Externí odkaz:
https://doaj.org/article/857a0b4422664920a2039f47a3fe44fd
Autor:
Longsha Liu, Thijs A. van Schaik, Kok-Siong Chen, Filippo Rossignoli, Paulo Borges, Vladimir Vrbanac, Hiroaki Wakimoto, Khalid Shah
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/0147e1c4c66745aca653b8bc05b417bf
Autor:
Jenna B. Honeycutt, Angela Wahl, Jacob K. Files, Alexis F. League, Barkha J. Yadav-Samudrala, J. Victor Garcia, Sylvia Fitting
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Since the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV) reservoir due to the relatively low penetration of many drugs utilized in cART into the centr
Externí odkaz:
https://doaj.org/article/d5ece5e4edd64dc59a5cd3a175ce3050
Publikováno v:
Folia Medica Indonesiana, Vol 60, Iss 2, Pp 134-140 (2024)
Highlights: 1. This study compared the serological markers of pristane-induced mice to humanized mouse models of lupus achieved by transplanting stem cells from lupus patients, which is a novel method in Indonesia. 2. This study will allow for more a
Externí odkaz:
https://doaj.org/article/edc646eb09654807a940242a7401ff38
Autor:
Lyu Chao, Han Feng, Gao Qian, Lv Limin, Lu Ziwei, Lu Shuangshuang, Li Xiaoyan, Hu Yuechao, Yang Mengjie, Zhao Yingze, Liu Jun, Lu Xuancheng, Duo Shuguang
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 3, Pp 337-346 (2024)
Abstract Background This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1. Methods Humanized fragments, consisting of the endothelial cell‐specific K18 promoter, human ST6GAL1‐encoding gene, and luci
Externí odkaz:
https://doaj.org/article/14e3185e52174fca93346a148c2b5202