Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Human trial"'
Autor:
Ute Klinkhardt, Mirjam Schunk, John Ervin, Christoph Schindler, Danny Sugimoto, Bruce Rankin, Ralf Amann, Martina Monti, Anna Kutschenko, Carsten Schumacher, Kristina Huber, Andreas Zeder, Nelli Heikkila, Arnaud M. Didierlaurent, Sylvia E. Schwarz, Madiha Derouazi
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Next-generation COVID-19 vaccines are being developed to expand the breadth of coverage against existing and future variants and to extend the duration of protection. Prime-2-CoV_Beta is an orf virus (ORFV) based multi-antigen COVID-19 vaccine that c
Externí odkaz:
https://doaj.org/article/ac42958aa7f6453581c61e1316c600ce
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate t
Externí odkaz:
https://doaj.org/article/0116ecedf75541d9827069d3e5bddbc2
Autor:
Edoardo Zaccaria, Tim Klaassen, Annick M. E. Alleleyn, Jos Boekhorst, Tamara Smokvina, Michiel Kleerebezem, Freddy J. Troost
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background The effects of fermented food consumption on the small intestine microbiome and its role on host homeostasis are largely uncharacterised as our knowledge on intestinal microbiota relies mainly on faecal samples analysis. We invest
Externí odkaz:
https://doaj.org/article/313ab90ce788494e975be4c34527818d
Publikováno v:
Publishers Weekly. 9/25/2023, Vol. 270 Issue 39, p89-89. 1/3p. 1 Color Photograph.
Autor:
Tingting Ma, Bei Cao, Lei Huang, Yuanxun Yang, Yan Geng, Pinhao Xie, Yu Zhao, Hui Lin, Kun Wang, Chunhe Wang, Runbin Sun, Juan Li
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Purpose: To evaluate the safety, tolerability, pharmacokinetics and immunogenicity of DS002 injection, an anti-nerve growth factor (anti-NGF) monoclonal antibody for treating pain conditions, in healthy Chinese subjects.Methods: This study was a sing
Externí odkaz:
https://doaj.org/article/a5cc87f1d96144faa796463962b53df9
Akademický článek
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Autor:
Pin Zhang, Binghe Xu, Lin Gui, Wenna Wang, Meng Xiu, Xiao Zhang, Guilan Sun, Xiaoyu Zhu, Jianjun Zou
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-9 (2021)
Abstract Background Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerability, pharmacokinetic
Externí odkaz:
https://doaj.org/article/d90b26c5c0984e26bded0075c4324f98
Autor:
Fabian Sandgruber, Anna-Lena Höger, Julia Kunze, Benjamin Schenz, Carola Griehl, Michael Kiehntopf, Kristin Kipp, Julia Kühn, Gabriele I. Stangl, Stefan Lorkowski, Christine Dawczynski
Publikováno v:
Nutrients, Vol 15, Iss 7, p 1645 (2023)
A 14-day randomized controlled study with a parallel design was conducted with 80 healthy participants. Intervention groups I (IG1) and II (IG2) received a defined background diet and consumed a smoothie enriched with either 15 g of Chlorella dry wei
Externí odkaz:
https://doaj.org/article/87a1233aa5a14d3fbab8b56d21c2cc07
Autor:
Epp Songisepp, Jelena Stsepetova, Merle Rätsep, Liina Kuus, Anneli Piir, Kalle Kilk, Marika Mikelsaar
Publikováno v:
Journal of Functional Foods, Vol 92, Iss , Pp 105064- (2022)
The specific effectiveness of the Lactiplantibacillus plantarum strain Inducia of human intestinal origin was evaluated by genomic technologies, biochemical methods, and clinical biomarkers. The whole-genome sequence of L. plantarum Inducia harbored
Externí odkaz:
https://doaj.org/article/d8a39302bbff490cab61dd16840efc8c
Autor:
Rui Chen, Xiaoduo Guan, Pei Hu, Yanli Dong, Yi Zhu, Tengfei Zhang, Jianjun Zou, Shuyang Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Targeting factor XI (FXI) is a promising therapeutic strategy for the treatment and prevention of thrombosis without increasing the risk of bleeding. Here, we assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of SHR228
Externí odkaz:
https://doaj.org/article/7478991a374e49fab0b5c950db5783f7