Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death

Autor: Patricia Thomas, Kaiyven A. Leslie, Hannah J. Welters, Noel G. Morgan

Publikováno v: Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-7 (2021)

Abstract Obesity is a major risk factor for type 2 diabetes (T2D) although the causal links remain unclear. A feature shared by both conditions however is systemic inflammation and raised levels of circulating fatty acids (FFA). It is widely believed

Externí odkaz: https://doaj.org/article/f37492318b8940a4b24c2035d303019a

Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death

Autor: Noel G. Morgan, Hannah J. Welters, Kaiyven A. Leslie, Patricia Thomas

Publikováno v: Nutrition & Metabolism
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-7 (2021)

Obesity is a major risk factor for type 2 diabetes (T2D) although the causal links remain unclear. A feature shared by both conditions however is systemic inflammation and raised levels of circulating fatty acids (FFA). It is widely believed that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26623919810f40a5b77f28fa1e0728b3
http://europepmc.org/articles/PMC7802137

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Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway.

Autor: Madec AM; 2INSERM U1060/University Lyon 1/Inra 1235, Lyon-Sud Medicine, Faculty, 165 Chemin du Grand Revoyet-BP 12, 69921 Oullins Cedex, France. anne-marie.coquelet-madec@univ-lyon1.fr., Cassel R, Dubois S, Ducreux S, Vial G, Chauvin MA, Mesnier A, Chikh K, Bosco D, Rieusset J, Van Coppenolle F, Thivolet C

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2013 Dec; Vol. 27 (12), pp. 5122-30. Date of Electronic Publication: 2013 Sep 05.