Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Human ferritin"'
Autor:
Giulio Fracasso, Elisabetta Falvo, Giada Tisci, Gianluca Sala, Gianni Colotti, Sara Cingarlini, Claudia Tito, Sandra Bibbo, Cristina Frusteri, Elisa Tremante, Elena Giordani, Patrizio Giacomini, Pierpaolo Ceci
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20770- (2023)
Background: Cancer is still among the leading causes of death all over the world. Improving chemotherapy and minimizing associated toxicities are major unmet medical needs. Recently, we provided a preliminary preclinical evaluation of a human ferriti
Externí odkaz:
https://doaj.org/article/25b7226ed4974a9dbaadcf2acec008ae
Publikováno v:
Engineering in Life Sciences, Vol 22, Iss 6, Pp 453-463 (2022)
Abstract Prokaryotic expression systems are widely used to produce many types of biologics because of their extreme conveniences and unmatchable cost. However, production of recombinant human ferritin light chain (rhFTL) protein is largely restrained
Externí odkaz:
https://doaj.org/article/9473921ca45e4fd4aa7caab9d42c7500
Autor:
Rosanna Lucignano, Ilaria Stanzione, Giarita Ferraro, Rocco Di Girolamo, Carolina Cané, Angela Di Somma, Angela Duilio, Antonello Merlino, Delia Picone
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
For their easy and high-yield recombinant production, their high stability in a wide range of physico-chemical conditions and their characteristic hollow structure, ferritins (Fts) are considered useful scaffolds to encapsulate bioactive molecules. N
Externí odkaz:
https://doaj.org/article/7247e7bef97147b998c6cbcc54bf93fc
Autor:
Mohamed Boumaiza, Imene Fhoula, Fernando Carmona, Maura Poli, Michela Asperti, Alessandra Gianoncelli, Michela Bertuzzi, Paolo Arosio, Mohamed Nejib Marzouki
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 1, Pp 117-127 (2021)
Hepcidin and ferritin are key proteins of iron homeostasis in mammals. In this study, we characterize a chimera by fusing camel hepcidin to a human ferritin H-chain to verify if it retained the properties of the two proteins. The construct (HepcH) is
Externí odkaz:
https://doaj.org/article/594eb4e0579f424daf244d1d7b59759c
Autor:
Elisabetta Falvo, Verena Damiani, Giamaica Conti, Federico Boschi, Katia Messana, Patrizio Giacomini, Michele Milella, Vincenzo De Laurenzi, Veronica Morea, Gianluca Sala, Giulio Fracasso, Pierpaolo Ceci
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Abstract Background Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be inaccessible to conventi
Externí odkaz:
https://doaj.org/article/9e69bc049eb0484e9987bd48a32027e6
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111825- (2021)
Cancer is a serious global health issue, and apoptosis is a logical and practical cancer therapeutic strategy. Apoptosis responses to internal and external signals. Both BH3 domain in the pro-apoptotic proteins and truncated BH3 domain can stimulate
Externí odkaz:
https://doaj.org/article/5fce32c080c442c8beef461d5f95b733
Akademický článek
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Autor:
Giamaica Conti, Martina Pitea, Riccardo Ossanna, Roberta Opri, Giada Tisci, Elisabetta Falvo, Giulio Innamorati, Esther Ghanem, Andrea Sbarbati, Pierpaolo Ceci, Giulio Fracasso
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1622 (2021)
Pancreatic cancer (PC) represents an intriguing topic for researchers. To date, the prognosis of metastasized PC is poor with just 7% of patients exceeding a five-year survival period. Thus, molecular modifications of existing drugs should be develop
Externí odkaz:
https://doaj.org/article/39a8cae188c14ca3b763e71c4222e23c
Autor:
Huang, Xinglu, Chisholm, Jane, Zhuang, Jie, Xiao, Yanyu, Duncan, Gregg, Chen, Xiaoyuan, Suk, Jung Soo, Hanes, Justin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2017 Aug 01. 114(32), E6595-E6602.
Externí odkaz:
https://www.jstor.org/stable/26486954
Akademický článek
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