Identification of serum miR-378 and miR-575 as diagnostic indicators and predicting surgical prognosis in human epilepsy

Autor: Li Xiuxiu, Gao Zhiqing, Ma Mei Ling, Li Li, Guo Shifeng

Publikováno v: Journal of Medical Biochemistry, Vol 41, Iss 2, Pp 184-190 (2022)

Background: Epilepsy (EP) is a common neurological disorder which is characterized by excessive abnormal synchronization of neuronal discharges in the brain due to chronic recurrent seizures of multiple etiologies. Variety of microRNAs have been asso

Externí odkaz: https://doaj.org/article/ffd69ae517be4a18ae6c783961acf2b7

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Gap Junctions Contribute to Ictal/Interictal Genesis in Human Hypothalamic Hamartomas

Autor: Jie Wu, Ming Gao, Stephen G. Rice, Candy Tsang, John Beggs, Dharshaun Turner, Guohui Li, Bo Yang, Kunkun Xia, Fenfei Gao, Shenfeng Qiu, Qiang Liu, John F. Kerrigan

Publikováno v: EBioMedicine, Vol 8, Iss C, Pp 96-102 (2016)

Human hypothalamic hamartoma (HH) is a rare subcortical lesion associated with treatment-resistant epilepsy. Cellular mechanisms responsible for epileptogenesis are unknown. We hypothesized that neuronal gap junctions contribute to epileptogenesis th

Externí odkaz: https://doaj.org/article/0df11f70db38449cb37d5eca4c9f2c85

Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy

Autor: Veronica Alfano, Eleonora Aronica, Alessandra Morano, Eleonora De Felice, Pierangelo Cifelli, Silvia Di Angelantonio, Eleonora Palma, Gabriele Ruffolo

Publikováno v: Brain Sciences
Volume 11
Issue 4
Brain Sciences, Vol 11, Iss 441, p 441 (2021)
Brain Sciences, 11(4):441. Multidisciplinary Digital Publishing Institute

GABAA receptors-(Rs) are fundamental for the maintenance of an efficient inhibitory function in the central nervous system (CNS). Their dysfunction is associated with a wide range of CNS disorders, many of which characterized by seizures and epilepsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e63f06e7aba9ce9e8ad98556c6e886

Slow oscillations open susceptible time windows for epileptic discharges

Autor: Charles Quairiaux, Shahan Momjian, Laurent Spinelli, Andreas Kleinschmidt, M. Seeck, Pierre Mégevand, Christian Bénar, Serge Vulliemoz, Laurent Sheybani

Publikováno v: Epilepsia
Epilepsia, Wiley, 2021, 62 (10), pp.2357-2371. ⟨10.1111/epi.17020⟩
Epilepsia (2021)

Objective: In patients with epilepsy, interictal epileptic discharges are a diag-nostic hallmark of epilepsy and represent abnormal, so- called “irritative” activity that disrupts normal cognitive functions. Despite their clinical relevance, thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9a790333d0872d2cf274626462b582
https://hal.archives-ouvertes.fr/hal-03509397