Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

Autor: Saskia Weber-Stiehl, Jan Taubenheim, Lea Järke, Christoph Röcken, Stefan Schreiber, Konrad Aden, Christoph Kaleta, Philip Rosenstiel, Felix Sommer

Publikováno v: BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)

Abstract Background Inflammation is characterized by a metabolic switch promoting glycolysis and lactate production. Hexokinases (HK) catalyze the first reaction of glycolysis and inhibition of epithelial HK2 protected from colitis in mice. HK2 expre

Externí odkaz: https://doaj.org/article/4775c804c5424dc280a2419e833ba653

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Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury

Autor: Mulder, GM, Nijboer, WN, Seelen, MA, Sandovici, M, Bos, EM, Melenhorst, WB, Trzpis, M, Kloosterhuis, NJ, Visser, L, Henning, RH, Leuvenink, HG, Ploeg, RJ, Sunnarborg, SW, van Goor, H

Publikováno v: JOURNAL OF PATHOLOGY, 221(2), 183-192. Wiley

The epidermal growth factor (EGF) receptor and its ligands are crucially involved in the renal response to ischaemia. We studied the heparin binding-epidermal growth factor (HB-EGF), a major ligand for the EGF receptor, in experimental and human isch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::96723f07c5eb97235e44d90e8cf584ab
https://doi.org/10.1002/path.2698

Comparison between fresh and fixed human biopsies using spectral and lifetime measurements: Fluorescence analysis using one and two photon excitations

Autor: Amira Zaylaa, D. Abi Haidar, A. Ibrahim, Pascale Varlet, Fanny Poulon, Marc Zanello, Bertrand Devaux

Publikováno v: 2015 International Conference on Advances in Biomedical Engineering (ICABME)
2015 International Conference on Advances in Biomedical Engineering (ICABME), Sep 2015, Beirut, Lebanon. ⟨10.1109/ICABME.2015.7323242⟩

International audience; The purpose of this study is to make a comparison between the fluorescence emissions of fresh extracted human biopsies and fixed human biopsies, in order to evaluate the impact of fixation on autofluoresence signal. Our group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41211f3381d33ea8ea0b724168e106e
https://www.hal.inserm.fr/inserm-01238642