Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function:an Ex Vivo Study

Autor: Mandeep Marwah, Hala Shokr, Lissette Sanchez-Aranguren, Shakil Ahmad, Raj Badhan, Keqing Wang

Publikováno v: Marwah, M K, Shokr, H, Sanchez-Aranguren, L, Badhan, R K S, Wang, K & Ahmad, S 2022, ' Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function : an Ex Vivo Study ', Pharmaceutical Research, vol. 39, no. 2, pp. 341-352 . https://doi.org/10.1007/s11095-021-03164-z

Purpose Hydrogen sulphide (H2S) is an important signalling molecule involved in the regulation of several physiological and pathophysiological processes. The objective of this study was to investigate the feasibility of transdermal delivery of ADT-OH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18579ddcfb98e9269edf2d5f93395c27
https://doi.org/10.1007/s11095-021-03164-z

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?

Autor: Maria C. Cid, Sander Willox, Elizabeth A. V. Jones, Giusy Di Conza, Donatella Ponti, Rosa Martín-Pérez, Roser Alba-Rovira, Ward Celus, Massimiliano Mazzone, Manuel Ehling

Publikováno v: Circ Res
Circulation Research, 127(6), 707-723. LIPPINCOTT WILLIAMS & WILKINS

Rationale: How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. Yet, mechanisms underlying vascular remodeling remain poorly established. A better understanding of these processes may lead to the desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5049a857d8a7f409e8a1cea5ba5528
https://pubmed.ncbi.nlm.nih.gov/32853096

Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells

Autor: Thomas Rathjen, Michael T. Watkins, Samuel M. Lockhart, Lars Melholt Rasmussen, Xuanchun Wang, Simone Rørdam Preil, Ditte Sørensen, Nishant Dwivedi, Brian T. O’Neill, Sally L. Dunwoodie, Hassan Albadawi, Christian Rask-Madsen, Hans Christian Beck

Publikováno v: Diabetes
Wang, X, Lockhart, S M, Rathjen, T, Albadawi, H, Sørensen, D, O'Neill, B T, Dwivedi, N, Rørdam Preil, S, Beck, H C, Dunwoodie, S L, Watkins, M T, Rasmussen, L M & Rask-Madsen, C 2016, ' Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells ', Diabetes, vol. 65, no. 12, pp. 3680-3690 . https://doi.org/10.2337/db16-0001

In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We identified 10 novel insulin-regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d4d9ab5bab1543594bb3917cd4aab
http://europepmc.org/articles/PMC5127242

Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution

Autor: James R. Sellers, Francisco Mesquita, Cláudia Brito, Christopher K. E. Bleck, Didier Cabanes, Sandra Maria Zákia Lian Sousa

Publikováno v: Toxins
Toxins, Vol 11, Iss 7, p 419 (2019)
Volume 11
Issue 7

Clostridium perfringens produces an arsenal of toxins that act together to cause severe infections in humans and livestock animals. Perfringolysin O (PFO) is a cholesterol-dependent pore-forming toxin encoded in the chromosome of virtually all C. per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501bbe193609018b897d54a8602ff834
https://doi.org/10.3390/toxins11070419

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Autor: Sampson, Amanda K., Irvine, Jennifer C., Shihata, Waled A., Dragoljevic, Dragana, Lumsden, Natalie, Huet, Olivier, Barnes, Tyrone, Unger, Thomas, Steckelings, Ulrike M., Jennings, Garry L., Widdop, Robert E., Chin-Dusting, Jaye P. F.

Publikováno v: Sampson, A K, Irvine, J C, Shihata, W A, Dragoljevic, D, Lumsden, N, Huet, O, Barnes, T, Unger, T, Steckelings, U M, Jennings, G L, Widdop, R E & Chin-Dusting, J P 2016, ' Compound 21, a selective agonist of angiotensin AT 2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo ', British Journal of Pharmacology, vol. 173, no. 4, pp. 729-740 . https://doi.org/10.1111/bph.13063
British Journal of Pharmacology, 173(4), 729-740. Wiley

Background and PurposeAngiotensin AT(2) receptors are upregulated in disease states such as atherosclerosis and blockade of the AT(2) receptors exacerbates plaque formation. Direct stimulation of these receptors is anti-atherogenic but the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::07d95cb3e8aa52d9f0965abac886cdab
https://europepmc.org/articles/PMC4742292/