Výsledky vyhledávání - "Human Clinical Articles"

Pharmacological effects of ex vivo mesenchymal stem cell immunotherapy in patients with acute kidney injury and underlying systemic inflammation

Autor: Sunny Nguyen, Arno W. Tilles, Jai Radhakrishnan, Elizabeth LaPointe, Chris Gemmiti, Mohamed G. Atta, Rita N. Barcia, Andrew Blair, Natalie Vaninov, Brian Miller, Biju Parekkadan, Madhav Swaminathan, Nelson Kopyt, Brian O'Rourke, Kausik Umanath, Ashley Allen

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1588-1601 (2021)
Stem Cells Translational Medicine

Mesenchymal stem cells (MSCs) have natural immunoregulatory functions that have been explored for medicinal use as a cell therapy with limited success. A phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a817215fb98e3b22e5cc242d7f3ad1e3
https://doaj.org/article/972534fc7b2b461b98b88dca1a0d590f

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Phase IV Postmarketing Surveillance Study Shows Continued Efficacy and Safety of Stempeucel in Patients with Critical Limb Ischemia Due to Buerger's Disease

Autor: K. Udaykumar, K. V. Prasanth, Anita Dhar, M. Rajkumar, Subhendu S. Mahapatra, Jijy Abraham, Mithun Chandrashekar, Sanjay Kala, Charan Thej, Santanu Dutta, Sanjay C. Desai, Pachaiyappan Viswanathan, Pawan Gupta, N.S. Raviraja, Radhakrishnan Raju, Muralikrishna Nekkanti, P Shivashankar, Hema Boggarapu, Arunanshu Behera

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1602-1613 (2021)

Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2e32137615910bf51ae0a0104b077
https://doi.org/10.1002/sctm.21-0197

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Acute kidney injury successfully treated with autologous granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34‐positive cell transplantation: A first‐in‐human report

Autor: Sumi Hidaka, Takayuki Asahara, Kunihiro Ishioka, Hidekazu Moriya, Toshitaka Tsukiyama, Shuzo Kobayashi, Yasuhiro Mochida, Tsutomu Sato, Takayasu Ohtake, Hiroyuki Suzuki, Marie Morota

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 9, Pp 1253-1257 (2021)
Stem Cells Translational Medicine

A 36-year-old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c415d5789fecc5d285f4b2ee76865945
https://doaj.org/article/7335bc302ead47a89c9297e96ac605aa

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Sibling umbilical cord blood infusion is safe in young children with cerebral palsy

Autor: Barbara Waters-Pick, Joanne Kurtzberg, Jessica Sun, Jesse D. Troy, Colleen McLaughlin, Gordon Worley, Joan Jasien, Mohamad A. Mikati, Laura E. Case

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 9, Pp 1258-1265 (2021)
Stem Cells Translational Medicine

Preclinical and early phase clinical studies suggest that an appropriately dosed umbilical cord blood (CB) infusion has the potential to help improve motor function in young children with cerebral palsy (CP). As many children with CP do not have thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760c42b784285adb91a27077739ec1a
https://doaj.org/article/d6e7598575dd4f6a93445b623563ba1d

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A pilot study on ex vivo expanded autologous adipose‐derived stem cells of improving fat retention in localized scleroderma patients

Autor: Bo Chen, Xiao Long, Yiwei Zhang, Loubin Si, Chenyu Wang, Robert Chunhua Zhao, Xiuqin Zhang, Xiaojun Wang, Tianyu Sun

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1148-1156 (2021)
Stem Cells Translational Medicine

In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality. Autologous fat grafting (AFG) is used for volume restoration but with low‐fat retention due to various reasons. Adipose‐d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbb5603f92402272dc575fec044d31c
https://doaj.org/article/09b650bd41d54151bc3b298794b4651e

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Treatment of chronic diabetic foot ulcers with adipose‐derived stromal vascular fraction cell injections: Safety and evidence of efficacy at 1 year

Autor: Nelson Garcia, Michael H. Carstens, Diego Correa, Dorian W. Calero, Kenneth A. Bertram, Joseph Rigdon, Santos T. Calderwood, María L. Zelaya, Francisco J. Quintana, Carlos M. Rivera, Juan P. Sevilla, Severiano Dos-Anjos, Arlen B. Ríos

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1138-1147 (2021)
Stem Cells Translational Medicine

Diabetes affects multiple systems in complex manners. Diabetic foot ulcers (DFUs) are a result of diabetes‐induced microarterial vessel disease and peripheral neuropathy. The presence of arteriosclerosis‐induced macroarterial disease can further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5a081f82bb04f96484a5769eab1d2d
https://doaj.org/article/de4e9e7ebc204f2694797feb2eb87461

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In the eye of the storm: SARS‐CoV‐2 infection and replication at the ocular surface?

Autor: Islam Mostafa, Joseph Collin, Rachel Queen, Francisco C Figueiredo, Lyle Armstrong, Majlinda Lako

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 976-986 (2021)
Stem Cells Translational Medicine

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) first emerged in December 2019 and spread quickly causing the coronavirus disease 2019 (COVID‐19) pandemic. Recent single cell RNA‐Seq analyses have shown the presence of SARS‐CoV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0a0bf1ac7073adcde60b710a280e4f
https://doaj.org/article/e3d062444ceb42a1bfcf35e02a9081e1

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Longitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells

Autor: Charles S. Cox, Susan Alderman, Xu Zhang, James C. Grotta, Sean I Savitz, Clark Sitton, Khader M. Hasan, Farhaan S Vahidy, Octavio Arevalo, Muhammad E Haque, Sarah D George, Seth B Boren, Jaroslaw Aronowski

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 943-955 (2021)
Stem Cells Translational Medicine

Bone marrow mononuclear cells (MNCs) attenuate secondary degeneration and enhance recovery in stroke animal models. In a nonrandomized clinical trial, we imaged 37 patients with stroke: 17 patients treated with MNCs (treated) and 20 patients who rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df30eee3599a5e2c0144895f4a1bf318
https://doaj.org/article/807999f2182f4fc8b1a5a5e06fce595a

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Adipose-derived regenerative cells and lipotransfer in alleviating breast cancer-related lymphedema: An open-label phase I trial with 4 years of follow-up

Autor: Jens Ahm Sørensen, Søren P. Sheikh, Ditte Caroline Andersen, Mads Gustaf Jørgensen, Navid Mohamadpour Toyserkani, Charlotte Harken Jensen

Publikováno v: Stem Cells Translational Medicine
Jørgensen, M G, Toyserkani, N M, Jensen, C H, Andersen, D C, Sheikh, S P & Sørensen, J A 2021, ' Adipose-derived regenerative cells and lipotransfer in alleviating breast cancer-related lymphedema : An open-label phase I trial with 4 years of follow-up ', Stem Cells Translational Medicine, vol. 10, no. 6, pp. 844-854 . https://doi.org/10.1002/sctm.20-0394
Stem Cells Translational Medicine, Vol 10, Iss 6, Pp 844-854 (2021)

Patients with breast cancer‐related lymphedema (BCRL) have reduced quality of life and arm function. Current treatments are palliative, and treatments improving lymphedema are lacking. Preclinical studies have suggested that adipose‐derived regen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56834c66733c1a45de0d57d51c93bedc
https://doi.org/10.1002/sctm.20-0394

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Benefits and obstacles to cell therapy in neonates: The INCuBAToR (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research)

Autor: Justin Presseau, Laurent Renesme, Kelly Cobey, Dean Fergusson, David Moher, Roger F. Soll, Sasha van Katwyk, Manoj M. Lalu, Bernard Thébaud, Brian Hutton, Kednapa Thavorn

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 968-975 (2021)
Stem Cells Translational Medicine

Cell‐based therapies hold promise to substantially curb complications from extreme preterm birth, the main cause of death in children below the age of 5 years. Exciting preclinical studies in experimental neonatal lung injury have provided the impe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c613957253e8af160c23bb346506f5
https://doi.org/10.1002/sctm.20-0508

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