Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Huma, Asif"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1432 (2024)
Over 70% of leiomyoma (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131 (GG). Myometrial cells are the cell origin of leiomyoma, but the MED12 mutation status in non-neoplastic myometrial cells is unknown. In this study, we investigated t
Externí odkaz:
https://doaj.org/article/b04e9bc0db1e45939f89c7764a432213
Autor:
Yinuo Li, Xiuhua Xu, Huma Asif, Yue Feng, Brendan F. Kohrn, Scott R. Kennedy, J. Julie Kim, Jian-Jun Wei
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-17 (2022)
Highlights High rate of MED12 mutations and leiomyoma burden are clearly associated with myometrial oxidative stress. MED12 mutations are driven by misrepair of 8-OHdG at c.130-c.131 detected by deep sequencing analysis both in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/fa4d73ee827a428fb574c9eddc9efbec
Publikováno v:
Gynecologic Oncology. 170:1-10
Racial disparities exist in cancer patients both in incidence and death rates. In endometrial cancer, Black patients are reported to have higher incidence of aggressive endometrial cancer subtypes and higher death rates than White women. To date, dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c33a903ee1489c9b7269f20b742f47
https://doi.org/10.1016/j.ygyno.2022.12.011
https://doi.org/10.1016/j.ygyno.2022.12.011
Autor:
Asif Iqbal, Mauricio Barbugiani Goldfeder, Rafael Marques-Porto, Huma Asif, Jean Gabriel de Souza, Fernanda Faria, Ana Marisa Chudzinski-Tavassi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or thrombosis. Thus, the identification of novel potent inhibitors of thrombin are of imme
Externí odkaz:
https://doaj.org/article/ba1295f0327f41e988619873c275f432
Autor:
Adriana S A Pereira, Murilo S Amaral, Elton J R Vasconcelos, David S Pires, Huma Asif, Lucas F daSilva, David A Morales-Vicente, Vitor C Carneiro, Claudia B Angeli, Giuseppe Palmisano, Marcelo R Fantappie, Raymond J Pierce, João C Setubal, Sergio Verjovski-Almeida
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006873 (2018)
BACKGROUND:The possibility of emergence of praziquantel-resistant Schistosoma parasites and the lack of other effective drugs demand the discovery of new schistosomicidal agents. In this context the study of compounds that target histone-modifying en
Externí odkaz:
https://doaj.org/article/3fd93080721c4521b0f7d53c1dfc4fc9
Publikováno v:
Journal of Peace, Development & Communication. 05:36-48
Pakistan has been facing the challenge of militancy since right after 9/11. Militancy means the use of violence for a political or social cause. Militancy exists from centuries and is directly challenged the security issues of any state. In a poor, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8286043d4e3baf1478f707db75b0eaad
https://doi.org/10.36968/jpdc-v05-i02-04
https://doi.org/10.36968/jpdc-v05-i02-04
Autor:
Zongchang Li, Shishi Min, Ney Alliey-Rodriguez, Gina Giase, Lijun Cheng, David Wesley Craig, Geoffrey J. Faulkner, Huma Asif, Chunyu Liu, Elliot S. Gershon
Publikováno v:
Neurobiology of aging.
Accumulation of somatic mutations in human neurons is associated with aging and neurodegeneration. To shed light on the somatic mutational burden in Alzheimer's disease (AD) neurons and get more insight into the role of somatic mutations in AD pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70e2751d1f94c2424b4508d18d5c4ce
https://pubmed.ncbi.nlm.nih.gov/36599749
https://pubmed.ncbi.nlm.nih.gov/36599749
Autor:
Yinuo Li, Xiuhua Xu, Huma Asif, Yue Feng, Brendan F. Kohrn, Scott R. Kennedy, J Julie Kim, Jian-Jun Wei
Background More than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130–131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promotes MED12 mutations in myome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae38c908741c157cf5d89a70d54e703e
https://doi.org/10.21203/rs.3.rs-1517048/v1
https://doi.org/10.21203/rs.3.rs-1517048/v1
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150772 (2016)
3-hydroxypropionaldehyde (3-HPA) and 1,3-propanediol (1,3-PD) are subproducts of glycerol degradation and of economical interest as they are used for polymers synthesis, such as polyesters and polyurethanes. Some few characterized bacterial species (
Externí odkaz:
https://doaj.org/article/5dea1e6ab30a4a1c8839f84db91029b1
Autor:
Zongchang Li, Huma Asif, Jinsong Tang, Honghong Ren, Ke Jin, Lulin Dai, Wenxiao Zheng, Ying He, Xiaogang Chen, Xiaoqian Ma, Dong Wang, Chunwang Li
Publikováno v:
Journal of Psychiatric Research. 123:136-144
The human gut microbiome plays an important role in the basic neurodevelopmental processes of the central nervous system and has been implicated in several neuropsychiatric disorders. However, the connection between the gut microbiome and the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5f129033bae656c13653635d6ae8dd
https://doi.org/10.1016/j.jpsychires.2020.02.005
https://doi.org/10.1016/j.jpsychires.2020.02.005