Mass spectrometric identification of isocyanate-induced modifications of keratins in human skin

Autor: Hulst, A.G., Verstappen, D.R.W., Riet-van Oeveren, D. van der, Vermeulen, N.P.E., Noort, D.

Publikováno v: Chemico-Biological Interactions, 237, 141-150

In the current paper we show that exposure of human callus to isocyanates leads to covalent modifications within keratin proteins. Mass spectrometric analyses of pronase digests of keratin isolated from exposed callus show that both mono- and di-addu

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Rapid and generic identification of respiratory viruses with mass spectrometry - Poster

Autor: Majchrzykiewicz-Koehorst, J.A., Heikens, E., Trip, H., Hulst, A.G., Jong, A.L. de, Viveen, M.C., Sedee, N.J.A., Plas, J. van der, Coenjaerts, F.E.J., Paauw, A.

Publikováno v: NVMM 2014, Arnhem, Nederland, 15-16 april 2014

Tested respiratory viruses: influenza A virus, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), were successfully identified directly from crude cell cultures using liquid chromatography-tandem MS (LC-MS/MS). The identification was

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New tools in diagnosis and biomonitoring of intoxications with organophosphorothioates: Case studies with chlorpyrifos and diazinon

Autor: Schans, M.J. van der, Hulst, A.G., Riet-Van Oeveren, D. van der, Noort, D., Benschop, H.P., Dishovsky, C.

Publikováno v: Chemico-Biological Interactions, 1, 203, 96-102

Organophosphate (OP) pesticides are neurotoxic compounds that are widely used in agriculture. Classical methods for monitoring OP exposure comprise the measurement of intact OP, its metabolites or cholinesterase activity. Newly developed methods focu

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Novel methods for point-of-care diagnosis of nerve agent exposure (Abstract)

Autor: Noort, D., Schans, M.J. van der, Fidder, A., Verstappen, D.R.W., Hulst, A.G., Mars-Groenendijk, R.

Publikováno v: 18th Biennial Medical Chemical Defense Bioscience Review, Baltimore Marriott Hunt Valley Inn, Hunt Valley, Maryland, USA, 20-24 May 2012, 47

Methods to unequivocally and rapidly assess exposure to nerve agents are highly valuable from a military and security perspective. Within this framework we currently follow two different approaches towards rapid point-of-care diagnosis. Regarding the

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Identification of outer membrane proteins of Yersinia pestis through biotinylation

Autor: Smither, S.J., Hill, J., Baar, B.L.M. van, Hulst, A.G., Jong, A.L. de, Titball, R.W.

Publikováno v: Journal of Microbiological Methods, 1 (January), 68, 26-31

The outer membrane of Gram-negative bacteria contains proteins that might be good targets for vaccines, antimicrobials or detection systems. The identification of surface located proteins using traditional methods is often difficult. Yersinia pestis,

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