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Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

Autor: Martinec, Ondrej, Biel, Carin, de Graaf, Inge A.M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas

Publikováno v: Frontiers in Pharmacology, 12:684156. Frontiers Media SA

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7c0f66e750698a89200b089333816703
https://research.rug.nl/en/publications/aa20d324-9112-4cd8-bd88-ab362d1709c5

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices.

Autor: Martinec O; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czechia.; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czechia., Biel C; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Groningen, Netherlands., de Graaf IAM; Graduate School of Science, Faculty of Science and Engineering, University of Groningen, Groningen, Netherlands., Huliciak M; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czechia., de Jong KP; Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Staud F; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czechia., Cecka F; Department of Surgery, University Hospital Hradec Kralove, Hradec Kralove, Czechia., Olinga P; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Groningen, Netherlands., Vokral I; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czechia., Cerveny L; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czechia.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 Jun 09; Vol. 12, pp. 684156. Date of Electronic Publication: 2021 Jun 09 (Print Publication: 2021).