ANTI-CARP ANTIBODIES IN TWO LARGE COHORTS OF PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR RELATIONSHIP TO GENETIC RISK FACTORS, CIGARETTE SMOKING AND OTHER AUTOANTIBODIES

Autor: Henrik Källberg, Lars Klareskog, Tineke J van Wesemael, Hulda Sigridur Hreggvidsdottir, Camilla Bengtsson, Leendert A. Trouw, René E. M. Toes, V Malmström, Diane van der Woude, Lena Israelsson, Tom W J Huizinga, Willem Verduijn, Jing Shi, Xia Jiang, Karin Lundberg, Lars Alfredsson

Publikováno v: Annals of the Rheumatic Diseases, 73, 510-511
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 73(10), 1761-8
Annals of the Rheumatic Diseases, 73(10), 1761-1768

Introduction In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anticitrullinated protein antibodies (ACPA), while much less is known about risk factors for ACPA-negative RA. Antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4285266d7831e4c6ed1977717ff5be5
http://hdl.handle.net/1887/107695

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Autor: Ben Lu, Huan Yang, Karin Palmblad, Haichao Wang, Shizuo Akira, Ulf Andersson, Yousef Al-Abed, Angelika Bierhaus, Kevin J. Tracey, Helena Erlandsson-Harris, Sangeeta S. Chavan, Hulda Sigridur Hreggvidsdottir, Mahendar Ochani, Jianhua Li, Mauricio Rosas-Ballina

During infection, vertebrates develop “sickness syndrome,” characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and inflammation. These pathophysiological responses are mediated by cytokines, including TNF and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5255779a96e4c74e1423ace6c19ae30c
https://europepmc.org/articles/PMC2900689/

AB0049 Human Type 1 Innate Lymphoid Cells Accumulate in the Inflamed Synovium in Spondyloarthritis

Autor: Troy Noordenbos, Jochem H. Bernink, Hulda Sigridur Hreggvidsdottir, N. Yeremenko, Iris C Blijdorp, Kristine Germar, Hergen Spits, Dominique Baeten

Publikováno v: Annals of the Rheumatic Diseases. 74:906.2-906

Background Spondyloarthritis (SpA) is a major form of chronic inflammatory arthritis characterized by inflammation of axial and peripheral joints and by pathologic new bone formation leading to ankylosis. Consistent genetic, experimental, and clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dffff5c326fde08c68225852f20ac91b
https://doi.org/10.1136/annrheumdis-2015-eular.5907

OP0239 Phenotypic and Molecular Profile of Innate Lymphoid Cells in Chronic Synovial Inflammation

Autor: Jenny Mjösberg, Jochem H. Bernink, Dominique Baeten, Hulda Sigridur Hreggvidsdottir, Hergen Spits

Publikováno v: Annals of the Rheumatic Diseases. 72:A133.2-A133

Background Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling [1]. The family comprises several phenotypically and functionally distinct subsets that produce various cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0804063526f6218e193d1cd63c39fff6
https://doi.org/10.1136/annrheumdis-2013-eular.444

HMGB1-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor

Autor: Ann-Charlotte Aveberger, Lena Klevenvall, Ulf Andersson, Helena Erlandsson Harris, Hulda Sigridur Hreggvidsdottir, Anna M. Lundberg

Publikováno v: Annals of the Rheumatic Diseases. 71:A80.1-A80

Background and objectives The pro-inflammatory protein HMGB1 is a pathogenic mediator in several inflammatory diseases as demonstrated by beneficial effects of HMGB1-blocking therapy in experimental models including arthritis. High levels of extracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::464f2bdec92c5d900bf495f7adcd0c46
https://doi.org/10.1136/annrheumdis-2011-201238.19