Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models

Autor: Huizing, Fokko J., Hoeben, Bianca A.W., Lok, Jasper, Boerman, Otto C., Heskamp, Sandra, Bussink, Johan

Publikováno v: In Physics and Imaging in Radiation Oncology July 2021 19:145-150

Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells

Autor: van Lith, Sanne A M, Huizing, Fokko J, Franssen, Gerben M, Hoeben, Bianca A W, Lok, Jasper, Doulkeridou, Sofia, Boerman, Otto C, Gotthardt, Martin, van Bergen En Henegouwen, Paul M P, Bussink, Johan, Heskamp, Sandra, Sub Cell Biology, Celbiologie

Publikováno v: Molecular Pharmaceutics, 19, 3511-3520
Molecular Pharmaceutics, 19(10), 3511. American Chemical Society
Molecular Pharmaceutics, 19, 10, pp. 3511-3520

Contains fulltext : 283433.pdf (Publisher’s version ) (Open Access) Hypoxic areas are present in the majority of solid tumors, and hypoxia is associated with resistance to therapies and poor outcomes. A transmembrane protein that is upregulated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862189908a8129b2deaa66bc7d6af3a4
http://hdl.handle.net/2066/283433

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Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells.

Autor: van Lith SAM; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Huizing FJ; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Franssen GM; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Hoeben BAW; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands., Lok J; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Doulkeridou S; Department of Cell Biology, University of Utrecht, Utrecht, 3584 GE, The Netherlands., Boerman OC; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Gotthardt M; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., van Bergen En Henegouwen PMP; Department of Cell Biology, University of Utrecht, Utrecht, 3584 GE, The Netherlands., Bussink J; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Heskamp S; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2022 Oct 03; Vol. 19 (10), pp. 3511-3520. Date of Electronic Publication: 2022 Jan 19.