Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Huixian Gan"'
Autor:
Amit Tuli, Mahak Sharma, Huixian Gan, Heinz G. Remold, Michael B. Brenner, Carolina Geadas, Xavier Michelet
Publikováno v:
The Journal of Immunology. 200:3160-3169
Mycobacterium tuberculosis is an extremely successful pathogen, and its success is widely attributed to its ability to manipulate the intracellular environment of macrophages. A central phenomenon of tuberculosis pathology enabling immune evasion is
Autor:
Xavier, Michelet, Amit, Tuli, Huixian, Gan, Carolina, Geadas, Mahak, Sharma, Heinz G, Remold, Michael B, Brenner
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(9)
Mycobacterium tuberculosis (Mtb) is an extremely successful pathogen and its success is widely attributed to its ability to manipulate the intracellular environment of macrophages. A central phenomenon of tuberculosis pathology enabling immune evasio
Autor:
Samuel M. Behar, Heinz G. Remold, Xiaomin Zhao, Martin Cj, Maziar Divangahi, Huixian Gan, Matthew G. Booty, Tomoyasu Nishimura
Publikováno v:
Mucosal Immunology. 4:279-287
Two different forms of death are commonly observed when Mycobacterium tuberculosis (Mtb)-infected macrophages die: (i) necrosis, a death modality defined by cell lysis and (ii) apoptosis, a form of death that maintains an intact plasma membrane. Necr
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(9)
Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Previously, we reported that in macrophages (Mφs), infection with avirulent Mtb H37Ra resulted in inhibition of n
Publikováno v:
Infection and Immunity. 63:1921-1926
Human macrophages (M phi) from most donors respond to inoculation with Mycobacterium avium serovar 4 (M. avium) by tumor necrosis factor alpha (TNF-alpha) production, which is of critical importance for proper defense against microorganisms. An initi
Autor:
Heinz G. Remold, Maziar Divangahi, Minjian Chen, Samuel M. Behar, David M. Lee, Tyler T. Hickman, Danielle Desjardins, Sarah M. Fortune, Huixian Gan
Publikováno v:
Nature immunology
Induction of macrophage necrosis is a strategy used by virulent Mycobacterium tuberculosis (Mtb) to avoid innate host defense. In contrast, attenuated Mtb causes apoptosis, which limits bacterial replication and promotes T cell cross-priming by antig
Interleukin-6 Expression in Primary Macrophages Infected with Human Immunodeficiency Virus-1 (HIV-1)
Publikováno v:
AIDS Research and Human Retroviruses. 7:671-679
We have investigated the effects of human immunodeficiency virus type-1 (HIV-1) infection on constitutive and lipopolysaccharide (LPS)-induced expression of interleukin-6 (IL-6) in cultured blood monocyte-derived macrophages. Highly productive and cy
Publikováno v:
Nature immunology. 9(10)
Macrophages infected with attenuated Mycobacterium tuberculosis strain H37Ra become apoptotic, which limits bacterial replication and facilitates antigen presentation. Here we demonstrate that cells infected with H37Ra became apoptotic after the form
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(6)
Infection of human monocyte-derived macrophages with Mycobacterium tuberculosis at low multiplicities of infection leads 48–72 h after the infection to cell death with the characteristics of apoptosis or necrosis. Predominant induction of one or th
Autor:
Lei Duan, Hardy Kornfeld, Heinz G. Remold, Huixian Gan, Elizabeth Mirabile-Levens, Xianbao He
Publikováno v:
The Journal of infectious diseases. 191(8)
Infection of human macrophages with Mycobacterium tuberculosis leads to cell death that, depending on the M. tuberculosis strain, time course, and multiplicity of infection, may have predominant features of apoptosis or necrosis. A key feature of inf