Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Huiwen W. Zhao"'
Autor:
Songyue Yin, Jin Xue, Haidan Sun, Bo Wen, Quanhui Wang, Guy Perkins, Huiwen W Zhao, Mark H Ellisman, Yu-hsin Hsiao, Liang Yin, Yingying Xie, Guixue Hou, Jin Zi, Liang Lin, Gabriel G Haddad, Dan Zhou, Siqi Liu
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74011 (2013)
Mitochondria are the primary organelles that consume oxygen and provide energy for cellular activities. To investigate the mitochondrial mechanisms underlying adaptation to extreme oxygen conditions, we generated Drosophila strains that could survive
Externí odkaz:
https://doaj.org/article/0d4cf1c38b1e434ba1a12adca2592216
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36801 (2012)
Through long-term laboratory selection, we have generated a Drosophila melanogaster population that tolerates severe, normally lethal, level of hypoxia. This strain lives perpetually under severe hypoxic conditions (4% O(2)). In order to shed light o
Externí odkaz:
https://doaj.org/article/f0c459cf6bcd4c2185ab7aa28ade7757
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11701 (2010)
Although oxidative stress is deleterious to mammals, the mechanisms underlying oxidant susceptibility or tolerance remain to be elucidated. In this study, through a long-term laboratory selection over many generations, we generated a Drosophila melan
Externí odkaz:
https://doaj.org/article/db230be0ab104615b7d502a1b93a38d3
Autor:
Yu Hsin Hsiao, Vineet Bafna, Dan Zhou, Gabriel G. Haddad, Roy Ronen, Orit Poulsen, Huiwen W. Zhao, Otto Appenzeller, Pedro Cabrales, Priti Azad
Publikováno v:
The Journal of Experimental Medicine
Azad and collaborators propose that Senp1 drives excessive erythropoiesis in high-altitude Andean dwellers suffering from chronic mountain sickness.
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwell
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwell
Identification of Candidate Genes Involved in the Survival of Drosophila in Extreme O 2 Environments
Autor:
Vineet Bafna, Ying Lu-Bo, Tsering Stobdan, Gabriel G. Haddad, Arya Iranmehr, Dan Zhou, Huiwen W. Zhao
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Otto Appenzeller, Xiang Q. Gu, David Callacondo, Gabriel G. Haddad, Alysson R. Muotri, Huiwen W. Zhao, Thanathom Chailangkarn, Dan Zhou, Guy Perkins, Orit Poulsen
Publikováno v:
Neuroscience. 288:187-199
Monge's disease, also known as chronic mountain sickness (CMS), is a disease that potentially threatens more than 140 million highlanders during extended time living at a high altitude (over 2500m). The prevalence of CMS in Andeans is about 15-20%, s
Autor:
Alysson R. Muotri, Juan Wang, Gabriel G. Haddad, Priti Azad, Huiwen W. Zhao, Orit Poulsen, Beatriz C.G. Freitas, Hang Yao
The sodium bicarbonate co-transporter (NBC) is the major bicarbonate-dependent acid-base transporter in mammalian astrocytes and has been implicated in ischemic brain injury. A malfunction of astrocytes could have great impact on the outcome of strok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d8d149c1d585a6c89d9f8bb512b221
https://escholarship.org/uc/item/7hd8h0df
https://escholarship.org/uc/item/7hd8h0df
Publikováno v:
PLoS ONE. 2010, Vol. 5 Issue 7, p1-8. 8p. 4 Graphs.
Publikováno v:
Antioxidants & Redox Signaling. 16:1071-1076
Prolonged hyperoxia exposure generates excessive reactive oxygen species (ROS) and potentially leads to oxidative injury in every organ. We have previously generated Drosophila melanogaster flies that tolerate extreme oxidative stress (90%–95% O2),
Autor:
Gabriel G. Haddad, Huiwen W. Zhao
Publikováno v:
Placenta. 32:S104-S108
Oxygen (O(2)) is essential for aerobic life; however, the level of O(2), whether too low (hypoxia) or too high (hyperoxia), can induce oxidative injury and increase morbidity and mortality. Disruption of O(2) homeostasis represents a major aspect of