Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Huiti Li"'
Autor:
Huiti Li, Yali Liu, Zian Xue, Li Zhang, Xiaoxue Ruan, Jintong Yang, Zhongjiao Fan, Hongfang Zhao, Yu Cao, Guoqiang Chen, Ying Xu, Lu Zhou
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Abstract Hypoxia inducible factor‐1α (HIF‐1α) plays a critical role in cellular adaptation to hypoxia and it is a potential therapeutic target for anti‐cancer drugs. Applying high‐throughput screening, here it is found that HI‐101, a smal
Externí odkaz:
https://doaj.org/article/d424d97313b04e23aace14a1d0dad293
Publikováno v:
Molecules, Vol 24, Iss 5, p 845 (2019)
Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis and biosynthesis to promote cancer cell proliferation, and is believed to be a promising target for cancer therapy. Herein, based on the anthraquinone scaffold, we synthesized 31 anthraquinone
Externí odkaz:
https://doaj.org/article/abacc54e7c46440b81924ac907aa8081
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1864-1869
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876328faa53c16440c4649241a263a5a
https://doi.org/10.1021/acsmedchemlett.2c00308
https://doi.org/10.1021/acsmedchemlett.2c00308
Publikováno v:
ACS medicinal chemistry letters. 13(12)
Hypoxia-inducible factor, also known as HIF, is a transcriptional factor universally found in mammalian cells. HIF-1 is one of the HIF-families and acts as a heterodimer consisting of α and β subunits. It is found to play significant roles in patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec297c643e8a9f8a22260ac106345bd4
https://pubmed.ncbi.nlm.nih.gov/36518694
https://pubmed.ncbi.nlm.nih.gov/36518694
Autor:
Xiaodan Zhang, Wei Lu, Xiaoxue Ruan, Zhu Chen, Penghui Wang, Qian Wang, Chenghong Peng, Qian Zhan, Deyong Ye, Luhua Lai, Xiongxiong Lu, Hongwei Li, Lulu Jiang, Chenlei Wen, Qingbing Wang, Min-Min Shi, Xinjing Wang, Xiaomei Tang, Yuting Dai, Sai-Juan Chen, Yuan Fang, Xiao-Qiang Xiang, Huiti Li, Min Li, Lu Zhou, Jinyan Huang, Yanhui Xu, Jing Chen, Baiyong Shen, Xun Sun, Ke Huang, Liwen Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 116:23264-23273
Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0287c89386e4485aba76a19cc149fb18
https://doi.org/10.1073/pnas.1914557116
https://doi.org/10.1073/pnas.1914557116
Autor:
Qi Xiangyu, Huiti Li, Tingbo Ding, Jibin Dong, Chen Yan, Min Wei, Shuang Hu, Yang Cao, Nengneng Cheng, Li Yali, Mo Mingguang, Bin Lou, Deyong Ye, Yong Chu, Xiaoxia Li, Xian-Cheng Jiang, Taomin Huang, Lu Zhou
Publikováno v:
European Journal of Medicinal Chemistry. 163:864-882
The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxyben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65229101f6fb5a13f083685e2d75e327
https://doi.org/10.1016/j.ejmech.2018.12.028
https://doi.org/10.1016/j.ejmech.2018.12.028
Autor:
Penghui Wang, Deyong Ye, Xiaodan Zhang, Motonari Uesugi, Lulu Jiang, Ke Huang, Chao Peng, Chuantao Fang, Mo Mingguang, Yang Jintong, Huiti Li, Ping Wu, Lu Zhou, Fa-Xing Yu, Yanhui Xu, Xiaoxue Ruan, Jian Li
Publikováno v:
ACS chemical biology. 15(3)
Post-translational modifications play vital roles in fine-tuning a myriad of physiological processes, and one of the most important modifications is acetylation. Here, we report a ligand-directed site-selective acetylation using KHAc, a derivative of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd58f5a8a354aa15fae16d125c45c46c
https://pubmed.ncbi.nlm.nih.gov/32069008
https://pubmed.ncbi.nlm.nih.gov/32069008
Publikováno v:
Molecules
Molecules, Vol 24, Iss 5, p 845 (2019)
Molecules, Vol 24, Iss 5, p 845 (2019)
Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis and biosynthesis to promote cancer cell proliferation, and is believed to be a promising target for cancer therapy. Herein, based on the anthraquinone scaffold, we synthesized 31 anthraquinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855790ead903af217366b78baea67d0e
http://europepmc.org/articles/PMC6429356
http://europepmc.org/articles/PMC6429356
Autor:
Xiaoxue Ruan, Ke Huang, Lulu Jiang, Ronghui Liang, Huiti Li, Changliang Shan, Deyong Ye, Lu Zhou
Publikováno v:
European journal of medicinal chemistry. 168
Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis, pentose phosphate pathway, and serine synthesis to promote tumor growth through the regulation of its substrate 3-phosphoglycerate (3 PG) and product 2-phosphoglycerate (2 PG). Herein, based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c741bad096a2c1858acf995a1d795a
https://pubmed.ncbi.nlm.nih.gov/30798052
https://pubmed.ncbi.nlm.nih.gov/30798052