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The Difference δ-Cells Make in Glucose Control

Autor: Huising, MO, van der Meulen, T, Huang, JL, Pourhosseinzadeh, MS, Noguchi, GM

Publikováno v: Huising, MO; van der Meulen, T; Huang, JL; Pourhosseinzadeh, MS; & Noguchi, GM. (2018). The Difference δ-Cells Make in Glucose Control. Physiology (Bethesda, Md.), 33(6), 403-411. doi: 10.1152/physiol.00029.2018. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/91r5h3vg

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We

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Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets

Autor: Huising, MO, Lee, S, van der Meulen, T

Publikováno v: Huising, MO; Lee, S; & van der Meulen, T. (2018). Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets. BioEssays. doi: 10.1002/bies.201800119. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9hw2p3zj

© 2018 WILEY Periodicals, Inc. We recently discovered a novel subset of beta cells that resemble immature beta cells during pancreas development. We named these “virgin” beta cells as they do not stem from existing mature beta cells. Virgin beta

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Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene

Autor: Pullen, T, Huising, MO, Rutter, GA

Publikováno v: Pullen, T J, Huising, M O & Rutter, G A 2017, ' Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene ', Frontiers in Genetics, vol. 8, pp. 41 . https://doi.org/10.3389/fgene.2017.00041
Pullen, TJ; Huising, MO; & Rutter, GA. (2017). Analysis of purified pancreatic islet beta and alpha cell transcriptomes reveals 11β-hydroxysteroid dehydrogenase (Hsd11b1) as a novel disallowed gene. Frontiers in Genetics, 8(APR), 41. doi: 10.3389/fgene.2017.00041. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3vq1r6h2

© 2017 Pullen, Huising and Rutter. We and others have previously identified a group of genes, dubbed "disallowed," whose expression is markedly lower in pancreatic islets than in other mammalian cell types. Forced mis-expression of several members o

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Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets

Autor: van der Meulen, T, Mawla, AM, DiGruccio, MR, Adams, MW, Nies, V, Dólleman, S, Liu, S, Ackermann, AM, Cáceres, E, Hunter, AE, Kaestner, KH, Donaldson, CJ, Huising, MO

Publikováno v: van der Meulen, T; Mawla, AM; DiGruccio, MR; Adams, MW; Nies, V; Dólleman, S; et al.(2017). Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets. Cell Metabolism, 25(4), 911-926.e6. doi: 10.1016/j.cmet.2017.03.017. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/85r6t1w6

© 2017 Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur exclusively via the replication of existing beta cells, but clinically meaningful restoration of human beta cell mass by proliferation has never been achiev

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