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Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors

Autor: Xin Zhai, Tong Li, Xinyu Wang, Zhi Cao, Yuxiang Chen, Hongrui Lei, Youbao Cui, Huinan Wu

Publikováno v: Bioorganicmedicinal chemistry. 46

A series of imidazo[1,2–a]pyridine compounds bearing urea moiety (8–27) were designed, synthesized and evaluated for their ATX inhibitory activities in vitro by FS-3 based enzymatic assay. Delightfully, benzylamine derivatives (14–27) exhibited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dfe09c0610b3cb66b871162b93d15c
https://pubmed.ncbi.nlm.nih.gov/34428714

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Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors

Autor: Hongrui Lei, Xinyu Wang, Guolong Zhao, Tong Li, Youbao Cui, Huinan Wu, Jing Yang, Nan Jiang, Xin Zhai

Publikováno v: European Journal of Medicinal Chemistry. 236:114307

Aiming to track the potential antitumor effect of novel allosteric autotaxin (ATX) inhibitors, a hybrid strategy was utilized by merging ATX inhibitors PF-8380 and GLPG1690, while the piperazinyl group in GLPG1690 was replaced with benzene ring to fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd10bb76d31c1533bf83f74d7904f1b6
https://doi.org/10.1016/j.ejmech.2022.114307

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Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model

Autor: Hongrui, Lei, Zhen, Li, Tong, Li, Huinan, Wu, Jing, Yang, Xinlian, Yang, Yu, Yang, Nan, Jiang, Xin, Zhai

Publikováno v: Bioorganic Chemistry. 120:105590

Aiming to develop novel allosteric autotaxin (ATX) inhibitors, hybrid strategy was utilized by assembling the benzyl carbamate fragment in PF-8380 onto the imidazo[1,2-a]pyridine skeleton of GLPG-1690. The piperazine moiety in GLPG-1690 was replaced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99136a01300d977b4562805df5c1e1b0
https://doi.org/10.1016/j.bioorg.2021.105590

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Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model

Autor: Hongrui Lei, Enlong Ma, Tong Li, Xin Zhai, Zhi Cao, Huinan Wu, Xinyu Wang, Lixin Sun, Yuxiang Chen

Publikováno v: European Journal of Medicinal Chemistry. 227:113951

In recent decades, pharmacological targeting of the autotaxin (ATX)/lysophosphatidic acid (LPA) axis accounted for excellent disease management benefits. Herein, to extend the scope of structure-activity relationships (SARs), fifteen indole-based car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e03f609ac2f86cdd7210163c1589ce
https://doi.org/10.1016/j.ejmech.2021.113951

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[Effects of thyroid autoimmunity on pregnancy outcomes in euthyroid women receiving in vitro fertilization: a meta-analysis]

Autor: Huinan, Wu, Tianpei, Hong, Hongwei, Gao, Haining, Wang

Publikováno v: Zhonghua yi xue za zhi. 95(46)

To investigate the association of thyroid autoimmunity (TAI) with pregnancy outcomes in euthyroid women undergoing in vitro fertilization (IVF).The meta-analysis was a systematic review of cohort studies published before May 10th, 2014. Data were ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae48f636380293a7fe924e1ab63b4ed7
https://pubmed.ncbi.nlm.nih.gov/26850020

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Research on Inefficient Investment of Listed Companies in China

Autor: Huinan Wu, Dongfang Qiu

Publikováno v: International Journal of Business and Management. 13:238

Using samples of A-share listed non-financial companies of 2015, This paper summarizes the research methods of inefficient investment and an effective method is chosen to measure the listed companies in China. The research in this paper shows that: C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f525fdb1af2aec6b481d2d927b476a8
https://doi.org/10.5539/ijbm.v13n1p238

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[Investigation of a rare supernumerary i(Y)(q10) chromosome in a patient with premature ovarian failure]

Autor: Huan, Zeng, Hui, Kong, Yunshan, Xiao, Tingting, Huang, Huinan, Wu, Yanyan, Shen, Yulin, Zhou

Publikováno v: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 31(2)

To investigate the origin of a rare supernumerary chromosome in a patient with premature ovarian failure (POF), and to explore the relationship between this abnormal karyotype and pathogenesis of POF.GTG banding karyotyping, Q-banding and fluorescenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ad3cb7e74f93f37881e88605c02a61d
https://pubmed.ncbi.nlm.nih.gov/24711030

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[Molecular and cytogenetic study on 5 cases with gonadal dysgenesis: clinical applications of fluorescence in situ hybridization(FISH) and BAC-FISH]

Autor: Qiong, Wu, Jian, Li, Huinan, Wu, Dongxing, Zhou, Meijiao, Cai, Yanyan, Shen, Chaoyi, Yang, Yunsheng, Ge, Hui, Kong, Xingli, Huang

Publikováno v: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 25(5)

To explore the applications of fluorescence in situ hybridization (FISH) in the diagnosis for the patients with gonadal dysgenesis.After routine gynecologic examination, ultrasonography and endocrine examination, 5 cases of gonadal dysgenesis and hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e48a20074166a537269c35bf909abdbc
https://pubmed.ncbi.nlm.nih.gov/18841574

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