Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Huimin Geng"'
Autor:
Yulin Zhang, Kaiyan Xi, Zhipeng Fu, Yuying Zhang, Bo Cheng, Fan Feng, Yuanmin Dong, Zezheng Fang, Yi Zhang, Jianyu Shen, Mingrui Wang, Xu Han, Huimin Geng, Lei Sun, Xingang Li, Chen Chen, Xinyi Jiang, Shilei Ni
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive behavior and a compromised immune response, presenting treatment challenges. Surgical debulking of GBM fails to address its highly infiltrative nature
Externí odkaz:
https://doaj.org/article/bcf6f2e919104f18948bf1b6fbd4d3a4
Autor:
Da‐Wang Zhao, Qian Cheng, Huimin Geng, Jinbo Liu, Yuanqiang Zhang, Jiwei Cui, Chao Liu, Lei Cheng
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract A major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism. The phenotype
Externí odkaz:
https://doaj.org/article/117689ab40304fffaed822093164a7ac
Autor:
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly und
Externí odkaz:
https://doaj.org/article/a2a886ce9d15408388b2e940336664d3
Autor:
Heather A. Ogana, Samantha Hurwitz, Chih-Lin Hsieh, Huimin Geng, Markus Müschen, Deepa Bhojwani, Mark A. Wolf, James Larocque, Michael R. Lieber, Yong Mi Kim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed. Artemis is a key endonuclease in V(D)J recombination and nonhomologous end joining (NHEJ) of DN
Externí odkaz:
https://doaj.org/article/16124452d48a4bd1a4732545972846eb
Autor:
Xing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Müschen, Jungmin Choi, Joao Pedro Pereira
Publikováno v:
eLife, Vol 12 (2023)
Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the molecular mechanisms driving these alterations remain poorly defined. Using
Externí odkaz:
https://doaj.org/article/7ea3554f599f436798d97bee226edbee
Autor:
Tsz-Yin Chan, Christina M. Egbert, Julia E. Maxson, Adam Siddiqui, Logan J. Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L. Pennington, Tsz-Ming Tsang, Madison Frey, Erik J. Soderblom, Huimin Geng, Markus Müschen, Tetyana V. Forostyan, Savannah Free, Gaelle Mercenne, Courtney J. Banks, Jonard Valdoz, Clifford J. Whatcott, Jason M. Foulks, David J. Bearss, Thomas O’Hare, David C. S. Huang, Kenneth A. Christensen, James Moody, Steven L. Warner, Jeffrey W. Tyner, Joshua L. Andersen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to T
Externí odkaz:
https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9
Autor:
Xunlei Kang, Changhao Cui, Chen Wang, Guojin Wu, Heyu Chen, Zhigang Lu, Xiaoli Chen, Li Wang, Jie Huang, Huimin Geng, Meng Zhao, Zhengshan Chen, Markus Müschen, Huan-You Wang, Cheng Cheng Zhang
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also demonstrated that Pir
Externí odkaz:
https://doaj.org/article/bb3ba6dd77ee4554832a15761a81e463
Autor:
Somayeh S. Tarighat, Fei Fei, Eun Ji Joo, Hisham Abdel-Azim, Lu Yang, Huimin Geng, Khuchtumur Bum-Erdene, I. Darren Grice, Mark von Itzstein, Helen Blanchard, Nora Heisterkamp
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12167 (2021)
Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-A
Externí odkaz:
https://doaj.org/article/88e52965b3874a80b7709ddfe968bb2e
Autor:
Elliot Stieglitz, Tali Mazor, Adam B. Olshen, Huimin Geng, Laura C. Gelston, Jon Akutagawa, Daniel B. Lipka, Christoph Plass, Christian Flotho, Farid F. Chehab, Benjamin S. Braun, Joseph F. Costello, Mignon L. Loh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors utilize DNA methylation based subgroups in JMML to predict clinical outcome.
Externí odkaz:
https://doaj.org/article/722c1dde424443b9b6f04f8e32625fea
Autor:
Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 482-495 (2017)
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pat
Externí odkaz:
https://doaj.org/article/3df8a0179df148b1b74368a6dccf96bb