Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Huilun Wang"'
Autor:
Yang Zhao, Yuhao Liu, Guizhen Zhao, Haocheng Lu, Yaozhong Liu, Chao Xue, Ziyi Chang, Hongyu Liu, Yongjie Deng, Wenying Liang, Huilun Wang, Oren Rom, Minerva T. Garcia-Barrio, Tianqing Zhu, Yanhong Guo, Lin Chang, Jiandie Lin, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113171- (2023)
Summary: Atherosclerosis, a leading health concern, stems from the dynamic involvement of immune cells in vascular plaques. Despite its significance, the interplay between chromatin remodeling and transcriptional regulation in plaque macrophages is u
Externí odkaz:
https://doaj.org/article/7f6e0a8a2aac415a91ad2bfbfacec5a1
Autor:
Guizhen Zhao, Yang Zhao, Haocheng Lu, Ziyi Chang, Hongyu Liu, Huilun Wang, Wenying Liang, Yuhao Liu, Tianqing Zhu, Oren Rom, Yanhong Guo, Lin Chang, Bo Yang, Minerva T. Garcia-Barrio, Jiandie D. Lin, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is critical for cardiac and skeletal myogenesis, yet little is known about i
Externí odkaz:
https://doaj.org/article/f481e3bf2ae0477d901fa50cbb6c472b
Autor:
Yonghong Luo, Yanhong Guo, Huilun Wang, Minzhi Yu, Kristen Hong, Dan Li, Ruiting Li, Bo Wen, Die Hu, Lin Chang, Jifeng Zhang, Bo Yang, Duxin Sun, Anna S. Schwendeman, Y. Eugene Chen
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103725- (2021)
Background: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no dru
Externí odkaz:
https://doaj.org/article/2e227778a8df4880ba2aab9c673f17a7
Autor:
Yuhao Liu, Ying Zhao, Yousef Shukha, Haocheng Lu, Lu Wang, Zhipeng Liu, Cai Liu, Yang Zhao, Huilun Wang, Guizhen Zhao, Wenying Liang, Yanbo Fan, Lin Chang, Arif Yurdagul, Jr., Christopher B. Pattillo, A. Wayne Orr, Michael Aviram, Bo Wen, Minerva T. Garcia-Barrio, Jifeng Zhang, Wanqing Liu, Duxin Sun, Tony Hayek, Y. Eugene Chen, Oren Rom
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109420- (2021)
Summary: Dysregulated glycine metabolism is emerging as a common denominator in cardiometabolic diseases, but its contribution to atherosclerosis remains unclear. In this study, we demonstrate impaired glycine-oxalate metabolism through alanine-glyox
Externí odkaz:
https://doaj.org/article/cd26e64f714e496680a0eaa2799a0feb
Autor:
Oren Rom, Guan Xu, Yanhong Guo, Yunhao Zhu, Huilun Wang, Jifeng Zhang, Yanbo Fan, Wenying Liang, Haocheng Lu, Yuhao Liu, Michael Aviram, Zhipeng Liu, Seongho Kim, Wanqing Liu, Xueding Wang, Y. Eugene Chen, Luis Villacorta
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 62-72 (2019)
Background: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a b
Externí odkaz:
https://doaj.org/article/8993aeb818a84d0696e92ce95f28eb8e
Autor:
Guizhen Zhao, Ziyi Chang, Yang Zhao, Yanhong Guo, Haocheng Lu, Wenying Liang, Oren Rom, Huilun Wang, Jinjian Sun, Tianqing Zhu, Yanbo Fan, Lin Chang, Bo Yang, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Krüppel-like factor 11 (KLF11) plays an essential role in maintaining v
Externí odkaz:
https://doaj.org/article/9de0556f12e74a12bf703fef9cfea9ce
Autor:
Yanhong Guo, Rui Kuai, Minzhi Yu, Die Hu, Jifeng Zhang, Huilun Wang, Wenmin Yuan, Anna Schwendeman, Y. Eugene Chen, Emily E. Morin, Bilian Yu, James J. Moon
Publikováno v:
Journal of Controlled Release. 329:361-371
Liver X nuclear receptor (LXR) agonists are promising anti-atherosclerotic agents that increase the expression of cholesterol transporters on atheroma macrophages leading to increased efflux of cholesterol to endogenous high-density lipoprotein (HDL)
Autor:
Tianqing Zhu, Ziyi Chang, Jifeng Zhang, Guizhen Zhao, Oren Rom, Yanbo Fan, Yanhong Guo, Huilun Wang, Lin Chang, Wenying Liang, Wenhao Xiong, Jinjian Sun, Y. Eugene Chen, Yang Zhao, Minerva T. Garcia-Barrio, Haocheng Lu
Publikováno v:
Circulation. 142:483-498
Background: Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA expansion and prevent aneurysm rupture. Transcription factor EB (TFEB), a mast
Autor:
Minerva T. Garcia-Barrio, Guizhen Zhao, Francisco J. Schopfer, Y. Eugene Chen, Lin Chang, Ziyi Chang, Yang Zhao, Bruce A. Freeman, Haocheng Lu, Huilun Wang, Wenhao Xiong, Yanbo Fan, Tianqing Zhu, Luis Villacorta, Yanhong Guo, Wenying Liang, Jifeng Zhang
Publikováno v:
Cardiovasc Drugs Ther
PURPOSE: Abdominal aortic aneurysm (AAA) is one of the leading causes of death in the developed world and is currently undertreated due to the complicated nature of the disease. Herein, we aimed to address the therapeutic potential of a novel class o
Autor:
Y. Eugene Chen, Yanbo Fan, Haocheng Lu, Daniel T. Eitzman, Huilun Wang, Jinjian Sun, Yanhong Guo, Wenying Liang, Jifeng Zhang, Guizhen Zhao
Publikováno v:
Thrombosis and haemostasis. 122(5)
Krüppel-like factors (KLFs) play essential roles in multiple biological functions, including maintaining vascular homeostasis. KLF11, a causative gene for maturity-onset diabetes of the young type 7, inhibits endothelial activation and protects agai