Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Huikai Sun"'
Publikováno v:
International Journal of Thermal Sciences. 188:108211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d982ca9e99abe885545634fd4269d5
https://doi.org/10.1016/j.ijthermalsci.2023.108211
https://doi.org/10.1016/j.ijthermalsci.2023.108211
Autor:
Richard Tjhen, Noriko Uchiyama, Michiko Tawada, Yohei Kosugi, Satoshi Endo, Huikai Sun, Kei Masuda, Makoto Fushimi, Tatsuki Koike, Weston Lane
Publikováno v:
Journal of Medicinal Chemistry. 64:1103-1115
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d202dd30fc9d83817cf7c025a625af2
https://doi.org/10.1021/acs.jmedchem.0c01712
https://doi.org/10.1021/acs.jmedchem.0c01712
Autor:
Todd Macklin, Mark Carlton, Hopkins Maria, Stephen Hitchcock, Hans H Schiffer, Deanna R Collia, Steve Moore, Kikuchi Shota, Nicole Marion English, Mark L. Adams, Murphy Sean, William J. Ray, Jason Green, Jason W. Brown, Holger Monenschein, Huikai Sun, Nicola Brice, Holly Reichard, Nidhi Kaushal
Publikováno v:
Journal of medicinal chemistry. 64(14)
Parkinson's disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a916c19bb4b6311dc8964de6bf626764
https://pubmed.ncbi.nlm.nih.gov/33861086
https://pubmed.ncbi.nlm.nih.gov/33861086
Autor:
Michiko, Tawada, Makoto, Fushimi, Kei, Masuda, Huikai, Sun, Noriko, Uchiyama, Yohei, Kosugi, Weston, Lane, Richard, Tjhen, Satoshi, Endo, Tatsuki, Koike
Publikováno v:
Journal of medicinal chemistry. 64(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23906eb1a0289169c4077ef979ed9857
https://pubmed.ncbi.nlm.nih.gov/33404239
https://pubmed.ncbi.nlm.nih.gov/33404239
Autor:
Victoria J Mulligan, Toni Cheung, Joseph Russo, Nidhi Kaushal, Nicola Brice, Louise Dickson, Darian Bartkowski, Steven A. Sheardown, Lee A. Dawson, Justin Powell, J Russell Burley, Stephen H Hitchcock, Natalie Hosea, Mark Carlton, Hans H Schiffer, Huikai Sun, Yun Chen, Jason Lawrence, Holger Monenschein, Murphy Sean, Anne Kanta, Xiao Xu, Keith Page
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(3)
GPR6 is an orphan G-protein–coupled receptor that has enriched expression in the striatopallidal, indirect pathway and medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7699037aeac8e0d7d1449554af6add50
https://pubmed.ncbi.nlm.nih.gov/33795395
https://pubmed.ncbi.nlm.nih.gov/33795395
Publikováno v:
In Journal of Organometallic Chemistry 2002 655(1):182-185
Publikováno v:
The Journal of Organic Chemistry. 77:8835-8839
A stereocontrolled intramolecular iron-mediated diene/olefin cyclocoupling reaction has been explored using vinyl ethers as the olefin partners. Spirolactams with functionalized (alkoxymethyl) side chains can be formed under thermal conditions. With
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e07e1fd53c78a0910e3c98e395232b
https://doi.org/10.1021/jo301721d
https://doi.org/10.1021/jo301721d
Publikováno v:
Tetrahedron. 66:4943-4946
A model study is described on a new approach to the synthesis of diquinane and angular triquinane systems, via iron-promoted tandem [6+2] ene-type double cyclization followed by ozonolysis and intramolecular aldol reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f6fdb0607e80381bb566c733cdef75d
https://doi.org/10.1016/j.tet.2010.05.018
https://doi.org/10.1016/j.tet.2010.05.018
Autor:
Huikai Sun, Anthony J. Pearson
Publikováno v:
The Journal of Organic Chemistry. 72:7693-7700
A stereospecific intramolecular iron tricarbonyl-promoted aldehyde-diene cyclocoupling reaction was investigated by using simple substrates 6 and more complicated substrates 30a/30b. Demetalation of the initial products converts all complexed dienes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f808669bc510917836351dd49c15d1
https://doi.org/10.1021/jo071124y
https://doi.org/10.1021/jo071124y
Publikováno v:
The Journal of Organic Chemistry. 72:2547-2557
Dynamic diastereoselectivity during Fe(CO) 3 promoted [6 + 2] ene spirocyclization of 35a and 35b, having a chiral center on the pendent side chain, was investigated and gave rise to products 28a and 28b instead of four possible isomers. From this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30978da80dfa2cd14c887352c25dcff
https://doi.org/10.1021/jo0625608
https://doi.org/10.1021/jo0625608