Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Huijing Xia"'
Autor:
Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (
Externí odkaz:
https://doaj.org/article/7aac073711094e04ba91e3ff73aa8fb6
Autor:
Jake Doiron, Zhen Li, Huijing Xia, Kyle B. Lapenna, Timothy D. Allerton, Daniel R. Kapusta, David J. Lefer
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 108-108 (2023)
OBJECTIVES/GOALS: SGLT2i therapy is currently a cornerstone in heart failure with preserved ejection fraction (HFpEF) therapy. Similarly, H2S has been shown to be beneficial in preclinical models of heart failure. With this in mind, we sought to inve
Externí odkaz:
https://doaj.org/article/7c8d629aa0cc47b5be07f44d739a356d
Autor:
Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, Jean Carnal, Karl H. Moles, Ya‐Xiong Tao, John Elrod, Josef Pfeilschifter, Karl‐Friedrich Beck, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)
Background Hydrogen sulfide (H2S) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system. Cystathionine γ‐lyase (CSE), 1 of 3 H2S producing enzyme, is predominantly localized in th
Externí odkaz:
https://doaj.org/article/c13eff3d2bb24ff8b38bcf1072bbc657
Autor:
Huijing Xia, Sonia Suda, Sharell Bindom, Yumei Feng, Susan B Gurley, Dale Seth, L Gabriel Navar, Eric Lazartigues
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22682 (2011)
Oxidative stress in the central nervous system mediates the increase in sympathetic tone that precedes the development of hypertension. We hypothesized that by transforming Angiotensin-II (AngII) into Ang-(1-7), ACE2 might reduce AngII-mediated oxida
Externí odkaz:
https://doaj.org/article/9b1bf537bb3d4e0b96a8ec1db06802fd
Autor:
Chetan P Hans, Yumei Feng, Amarjit S Naura, Mourad Zerfaoui, Bashir M Rezk, Huijing Xia, Alan D Kaye, Khalid Matrougui, Eric Lazartigues, A Hamid Boulares
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7430 (2009)
The aims of this study were to investigate the role of poly(ADP-ribose) polymerase (PARP)-1 in dyslipidemia-associated vascular dysfunction as well as autonomic nervous system dysregulation. Apolipoprotein (ApoE)(-/-) mice fed a high-fat diet were us
Externí odkaz:
https://doaj.org/article/8fc1448e202047558e2660f7dc6fce0f
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, Antonia Katsouda, John W. Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, Shi Xu, Ming Xian, Traci T. Goodchild, Andreas Papapetropoulos, David J. Lefer
Publikováno v:
Circulation Research. 132:154-166
Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen-sulfide–producing enzyme, is predominantly localized in the vascu
Autor:
Zhen, Li, Huijing, Xia, Thomas E, Sharp, Kyle B, LaPenna, John W, Elrod, Kevin M, Casin, Ken, Liu, John W, Calvert, Vinh Q, Chau, Fadi N, Salloum, Shi, Xu, Ming, Xian, Noriyuki, Nagahara, Traci T, Goodchild, David J, Lefer
Publikováno v:
Circulation research. 131(3)
Hydrogen sulfide (HHuman myocardial samples obtained from patients with heart failure undergoing cardiac surgeries were probed for 3-MST protein expression. 3-MST knockout mice and C57BL/6J wild-type mice were subjected to transverse aortic constrict
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, John W. Elrod, Kevin M. Casin, Ken Liu, John W. Calvert, Vinh Q. Chau, Fadi N. Salloum, Shi Xu, Ming Xian, Noriyuki Nagahara, Traci T. Goodchild, David J. Lefer
Publikováno v:
Circulation Research. 131:222-235
Background: Hydrogen sulfide (H 2 S) exerts mitochondria-specific actions that include the preservation of oxidative phosphorylation, biogenesis, and ATP synthesis, while inhibiting cell death. 3-MST (3-mercaptopyruvate sulfurtransferase) is a mitoch
Autor:
Jake E. Doiron, Kyle Lapenna, Zhen Li, Huijing Xia, Traci Goodchild, Ming Xian, Jianming Kang, David Lefer
Publikováno v:
The FASEB Journal. 36
Autor:
Kyle B. LaPenna, Zhen Li, Thomas E. Sharp, Karl H. Mose, Jake E. Doiron, Huijing Xia, Traci T. Goodchild, David J. Lefer
Publikováno v:
The FASEB Journal. 36