Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Huihui Chong"'
Autor:
Yuanmei Zhu, Xiaojing Dong, Nian Liu, Tong Wu, Huihui Chong, Xiaobo Lei, Lili Ren, Jianwei Wang, Yuxian He
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1819-1827 (2022)
The emergence of SARS-CoV-2 Omicron and other variants of concern (VOCs) has brought huge challenges to control the COVID-19 pandemic, calling for urgent development of effective vaccines and therapeutic drugs. In this study, we focused on characteri
Externí odkaz:
https://doaj.org/article/0d5c5a1aa86e4643b6d6f871846a2264
Autor:
Yue Chen, Hongliang Jin, Xiaoran Tang, Li Li, Xiuzhu Geng, Yuanmei Zhu, Huihui Chong, Yuxian He
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 30-49 (2022)
Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to achieve a sterilizing or functional cure. We recently reported that glycosylphosphatidylinositol (GPI)-anchored nanobody or a fusion inhibitory peptide c
Externí odkaz:
https://doaj.org/article/4b0faa14e2194c80b4e3d1428a4bc082
Autor:
Lin He, Chen Wang, Yuanyuan Zhang, Huihui Chong, Xiaoyan Hu, Dan Li, Hui Xing, Yuxian He, Yiming Shao, Kunxue Hong, Liying Ma
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Lipopeptide-19, a HIV fusion inhibitor (LP-19), has showed potent anti-HIV activity. However, there is still limited information of the antiviral activity against different subtype clinical isolates and the drug resistance barrier of LP-19. Therefore
Externí odkaz:
https://doaj.org/article/8983532f22174fd2b3f769e6769b865d
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
LCB1 is a 56-mer miniprotein computationally designed to target the spike (S) receptor-binding motif of SARS-CoV-2 with potent in vitro and in vivo inhibitory activities (Cao et al., 2020; Case et al., 2021). However, the rapid emergence and epidemic
Externí odkaz:
https://doaj.org/article/c8b7ba5d3db1439db71937eaa6709e2f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a
Externí odkaz:
https://doaj.org/article/813bd7bb4ea44140a82f1bad16d5e04a
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/cf4428d1410c447a907b140457c0d8b4
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 810-821 (2021)
EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antivi
Externí odkaz:
https://doaj.org/article/e7e7a14e842d42b4b3fbc535e9bf9c7c
Autor:
Danwei Yu, Yuanmei Zhu, Tao Jiao, Tong Wu, Xia Xiao, Bo Qin, Huihui Chong, Xiaobo Lei, Lili Ren, Sheng Cui, Jianwei Wang, Yuxian He
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1227-1240 (2021)
The ongoing pandemic of COVID-19, caused by SARS-CoV-2, has severely impacted the global public health and socio-economic stability, calling for effective vaccines and therapeutics. In this study, we continued our efforts to develop more efficient SA
Externí odkaz:
https://doaj.org/article/38e08a6bd85649bb864ced43a44b672a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6638 (2022)
In our previous work, we replaced the TRM (tryptophan-rich motif) of T20 (Enfuvirtide) with fatty acid (C16) to obtain the novel lipopeptide LP-40, and LP-40 displayed enhanced antiviral activity. In this study, we investigated whether the C16 modifi
Externí odkaz:
https://doaj.org/article/b13844d4709f498db538806eb8a12991
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007552 (2019)
Combination antiretroviral therapy (cART) dramatically improves survival of HIV-infected patients, but lifelong treatment can ultimately result in cumulative toxicities and drug resistance, thus necessitating the development of new drugs with signifi
Externí odkaz:
https://doaj.org/article/785b6ae720c448ffa8700528c51fe436