Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Huihua Xiong"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles and underlying mechanisms in triple-negative breast cancer (TNBC) remain incompletely unde
Externí odkaz:
https://doaj.org/article/84c5ce0d391b4cccbb88a3cf1719c211
Autor:
Zhe-Yu Hu, Min Yan, Huihua Xiong, Li Ran, Jincai Zhong, Ting Luo, Tao Sun, Ning Xie, Liping Liu, Xiaohong Yang, Huawu Xiao, Jing Li, Binliang Liu, Quchang Ouyang
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Human epidermal growth factor receptor 2 (HER2) targeted therapy combined with endocrine therapy has been recommended as an alternative treatment strategy for patients with hormone receptor (HR)-positive, HER2-positive metastatic
Externí odkaz:
https://doaj.org/article/945eca1f6a834632920aa7e7321a30fe
Autor:
Jiahao Li, Chen Gong, Haiting Zhou, Junxia Liu, Xiaohui Xia, Wentao Ha, Yizhi Jiang, Qingxu Liu, Huihua Xiong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5489 (2024)
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically for cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family.
Externí odkaz:
https://doaj.org/article/95b7517280b24bdbbc727c894337b4ee
Autor:
Yizhi Jiang, Haiting Zhou, Junxia Liu, Wentao Ha, Xiaohui Xia, Jiahao Li, Tengfei Chao, Huihua Xiong
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 652 (2024)
Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targete
Externí odkaz:
https://doaj.org/article/4c58d8e65dab42e9b2bce9235b48759c
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells pr
Externí odkaz:
https://doaj.org/article/6c6d701c42b74a539ffac0ebd1308269
Publikováno v:
Translational Oncology, Vol 32, Iss , Pp 101659- (2023)
Backgrounds: Ovarian cancer (OC) is the second most common gynecological tumor with the highest mortality rate worldwide. High FAM111B expression has been reported as a predictor of poor prognosis in other cancers, but its correlation with OC has not
Externí odkaz:
https://doaj.org/article/257d6de81a074d1abcd2905a5e65780c
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Hepatocellular carcinoma (HCC) is the most common neoplasm and the major cause of cancer-associated death worldwide. The high mortality rate of HCC is mainly attributed to its widespread prevalence and the lack of effective treatment. Immuno
Externí odkaz:
https://doaj.org/article/b9ed94585f6b4dd381c51d2c042efdc5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: Elevated expression of Copine-1 (CPNE1) has been proved in various cancers; however, the underlying mechanisms by which it affects clear cell renal cell carcinoma (ccRCC) are unclear.Methods: In this study, we applied multiple bioinformat
Externí odkaz:
https://doaj.org/article/ae2aec93785f4390b77610eda20876e8
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1450 (2023)
HER2 is highly expressed in a variety of malignant tumors and affects the prognosis of patients, making it a highly sensitive target for cancer therapy. Since the approval of the first HER2 inhibitor, trastuzumab, in 1998, HER2-targeted drugs have ra
Externí odkaz:
https://doaj.org/article/f653f1a47f8f43fdb70e499db3e8ba98
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMethylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme encoded in the nucleus. It plays a significant role in the regulation of glucose, nucleic acid, and folate metabolism, and maintains redox balance in
Externí odkaz:
https://doaj.org/article/3cdaa56ad56e44fcaa16ef0dee13e6ea