Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Huifen Faye, Wang"'
Autor:
Seth Schulman, Huifen Faye Wang, Feng Qiu, Xiongfe Wu, Penelope Crownover, Joan M. Korth-Bradley, Juanzhi Fang
Publikováno v:
Clinical Pharmacology in Drug Development. 3:235-241
This open-label, nonrandomized study was conducted to evaluate the steady-state pharmacokinetics of sirolimus in 24 stable Chinese renal transplant patients receiving daily oral maintenance doses of sirolimus (1-4 mg). Repeated trough and serial whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e563f9668fcbac3de2d0532820d33a
https://doi.org/10.1002/cpdd.96
https://doi.org/10.1002/cpdd.96
Publikováno v:
Bioanalysis. 2:1125-1140
Most therapeutic monoclonal antibodies are designed to bind a specific antigen to elicit pharmacological effects. Accurate quantification of a therapeutic monoclonal antibody in biological matrices is essential for assessing its pharmacokinetics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceafab9873f7a6348848317a2974711
https://doi.org/10.4155/bio.10.64
https://doi.org/10.4155/bio.10.64
Publikováno v:
Journal of clinical pharmacology. 55
Registration of innovative biologics in Emerging Markets (EMs) poses many opportunities and challenges. The BRIC-MT countries (Brazil, Russia, India, China, Mexico, and Turkey) that are the fastest growing markets and regulators in these countries ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78b96b01b47d83d1e7cddabc6725532
https://pubmed.ncbi.nlm.nih.gov/25707959
https://pubmed.ncbi.nlm.nih.gov/25707959
Autor:
Huifen Faye Wang, Qinmi Wang, Grazyna D. Szklarz, Tammy L. Domanski, Linlong Xue, James R. Halpert, Maria Almira Correia
Publikováno v:
Chemical Research in Toxicology. 14:483-491
The major human liver drug-metabolizing cytochrome P450 enzymes P450 3A4 and P450 3A5 share >85% amino acid sequence identity yet exhibit different regioselectivity toward aflatoxin B(1) (AFB(1)) biotransformation [Gillam et al. (1995) Arch. Biochem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58db40bb94e4aa7e721a9b54e780b7b
https://doi.org/10.1021/tx000218z
https://doi.org/10.1021/tx000218z
Autor:
Huifen Faye, Wang, Feng, Qiu, Xiongfe, Wu, Juanzhi, Fang, Penelope, Crownover, Joan, Korth-Bradley, Seth, Schulman
Publikováno v:
Clinical pharmacology in drug development. 3(3)
This open-label, nonrandomized study was conducted to evaluate the steady-state pharmacokinetics of sirolimus in 24 stable Chinese renal transplant patients receiving daily oral maintenance doses of sirolimus (1-4 mg). Repeated trough and serial whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e533e366dbc873c69fb4229e3241ddef
https://pubmed.ncbi.nlm.nih.gov/27128614
https://pubmed.ncbi.nlm.nih.gov/27128614
Publikováno v:
Archives of biochemistry and biophysics. 365(1)
Mechanism-based inactivation of liver microsomal cytochromes P450 3A (CYP 3A, P450s 3A) in vivo and/or in vitro, via heme modification of the protein, results in accelerated proteolytic degradation of the enzyme that is preceded by the ubiquitination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620b6d0df0e653769d7d949a54974488
https://pubmed.ncbi.nlm.nih.gov/10222037
https://pubmed.ncbi.nlm.nih.gov/10222037