Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Huifen Cao"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for
Externí odkaz:
https://doaj.org/article/6d01d6c69f1f423591b49865e62faa01
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background We recently developed two high-resolution methods for genome-wide mapping of two prominent types of DNA damage, single-strand DNA breaks (SSBs) and abasic (AP) sites and found highly complex and non-random patterns of these lesion
Externí odkaz:
https://doaj.org/article/cb42d8e347ca4d26b7f8c497150a21e8
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-31 (2023)
Abstract Background Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While a plethora of studies have connected a significant fraction of human DNA to various biochem
Externí odkaz:
https://doaj.org/article/1682f5f597db41ec819fa044823ad045
Autor:
Fang Wang, Huifen Cao, Qiu Xia, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized cellular enzymes represents one of the most common post-transcriptional RNA modifications with emerging connection to disease. A-to-I conversions can
Externí odkaz:
https://doaj.org/article/1ccf092095bb4229bc8f8b85cb8bf391
Publikováno v:
Microorganisms, Vol 12, Iss 4, p 814 (2024)
The past decades have witnessed intensive research on the biological effects of graphene-based nanomaterials (GBNs) and the application of GBNs in different fields. The published literature shows that GBNs exhibit inhibitory effects on almost all mic
Externí odkaz:
https://doaj.org/article/ae7be635573a466fade6dbd26632cfaf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Abasic (AP) sites represent a prominent type of DNA damage, yet the genomics of this lesion remains unexplored. Here, the authors report a method to map such sites at the nucleotide level in complex genomes and use it to extract complex age- and tiss
Externí odkaz:
https://doaj.org/article/464db374b82548cf8d230a3ef9ea8197
Autor:
Dongyang Xu, Yu Huang, Lingcong Luo, Lu Tang, Meng Lu, Huifen Cao, Fang Wang, Yong Diao, Liudmila Lyubchenko, Philipp Kapranov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12062 (2023)
Endogenous single-stranded DNA (essDNA) can form in a mammalian genome as the result of a variety of molecular processes and can both play important roles inside the cell as well as have detrimental consequences to genome integrity, much of which rem
Externí odkaz:
https://doaj.org/article/0cd0a6c144d04d0c945631a6b8f5ff54
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Single-strand breaks (SSBs) represent one of the most common types of DNA damage, yet not much is known about the genome landscapes of this type of DNA lesions in mammalian cells. Here, we found that SSBs are more likely to occur in certain positions
Externí odkaz:
https://doaj.org/article/1f411da3401049929af86ef1f9ad3472
Autor:
Huifen Cao, Dongyang Xu, Ye Cai, Xueer Han, Lu Tang, Fan Gao, Yao Qi, DingDing Cai, Huifang Wang, Maxim Ri, Denis Antonets, Yuri Vyatkin, Yue Chen, Xiang You, Fang Wang, Estelle Nicolas, Philipp Kapranov
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-24 (2021)
Abstract Background The majority of the human genome is transcribed in the form of long non-coding (lnc) RNAs. While these transcripts have attracted considerable interest, their molecular mechanisms of function and biological significance remain con
Externí odkaz:
https://doaj.org/article/f8c11f8e08bb498fa81fb30c0f58843e
Autor:
Huifen Cao, Philipp Kapranov
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Most of the human genome is transcribed to generate a multitude of non-coding RNAs. However, while these transcripts have generated an immense amount of scientific interest, their biological function remains a subject of an intense debate. Understand
Externí odkaz:
https://doaj.org/article/6a9d8c18e5e04c12bef9d206588c84de