Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Huidong Yu"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Esophageal squamous cell carcinoma (ESCC) is a malignancy with high incidence in China. Due to the lack of effective molecular targets, the prognosis of ESCC patients is poor. It is urgent to explore the pathogenesis of ESCC to identify promising the
Externí odkaz:
https://doaj.org/article/0d934c8be2a644ae92d460330ac2f63e
Autor:
Peichen Pan, Huidong Yu, Qinglan Liu, Xiaotian Kong, Hu Chen, Jiean Chen, Qi Liu, Dan Li, Yu Kang, Huiyong Sun, Wenfang Zhou, Sheng Tian, Sunliang Cui, Feng Zhu, Youyong Li, Yong Huang, Tingjun Hou
Publikováno v:
ACS Central Science, Vol 3, Iss 11, Pp 1208-1220 (2017)
Externí odkaz:
https://doaj.org/article/dec039c48c8c41a3ba5287bb397d44c1
Autor:
Chao Shen, Hui Liu, Xuwen Wang, Tailong Lei, Ercheng Wang, Lei Xu, Huidong Yu, Dan Li, Xiaojun Yao
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB pathway, has been proved to be an important target for the regulation of the immune system. In the past few years, NIK inhibitors with various scaf
Externí odkaz:
https://doaj.org/article/6cbaf5a72d13478a99b276b6962a8453
Autor:
Qiwen Liao, Guiyi Gong, Shirley Weng In Siu, Clarence Tsun Ting Wong, Huidong Yu, Yu Chung Tse, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee
Publikováno v:
Toxins, Vol 10, Iss 6, p 238 (2018)
Palythoa caribaeorum (class Anthozoa) is a zoantharian which, together with other cnidarians, like jellyfishes, hydra, and sea anemones, possesses specialized structures in its tissues, the cnidocytes, which deliver an array of toxins in order to cap
Externí odkaz:
https://doaj.org/article/f67f7e0bb6b34b1ebb3818ecbf5c9e8d
Publikováno v:
Arabian Journal of Geosciences. 13
The tectonic affinity of South China in paleogeographic reconstructions of the Gondwana supercontinent during the Early Paleozoic remains controversial. Here, we present new detrital monazite U–Pb age data from Lower Devonian Posongchong Formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84fdd84f2e0f338e1dd4ab9f85552757
https://doi.org/10.1007/s12517-020-05541-1
https://doi.org/10.1007/s12517-020-05541-1
Autor:
Feng Zhu, Peichen Pan, Xuwen Wang, Feng Liu, Huiyong Sun, Yong Huang, Jean J. Zhao, Sheng Tian, Tingjun Hou, Jiean Chen, Huidong Yu, Miyang Li, Jing Ni, Li Xijian
Publikováno v:
Journal of Medicinal Chemistry. 61:8613-8624
Camptothecin (CPT) has been shown to block disassembly of the topoisomerase-I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability and severe toxicity of CPTs have limited their clinical applications. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3969912de62a37a2ec0d1bf8608332
https://doi.org/10.1021/acs.jmedchem.8b00498
https://doi.org/10.1021/acs.jmedchem.8b00498
Autor:
Yu Kang, Qinglan Liu, Huiyong Sun, Hu Chen, Peichen Pan, Dan Li, Feng Zhu, Wenfang Zhou, Yong Huang, Xiaotian Kong, Huidong Yu, Tingjun Hou, Youyong Li, Sunliang Cui, Jiean Chen, Sheng Tian, Qi Liu
Publikováno v:
ACS Central Science, Vol 3, Iss 11, Pp 1208-1220 (2017)
Targeted inhibition of anaplastic lymphoma kinase (ALK) dramatically improved therapeutic outcomes in the treatment of ALK-positive cancers, but unfortunately patients invariably progressed due to acquired resistance mutations in ALK. Currently avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7eaf86c7a58a4c7ba04e3061901f9f
https://doi.org/10.1021/acscentsci.7b00419
https://doi.org/10.1021/acscentsci.7b00419
Publikováno v:
Advanced Synthesis & Catalysis. 359:1379-1387
An unprecedented 6π-electrocyclization–aromatization cascade reaction of ynedienamines is described. The electron-rich ynedienamine is converted by γ-protonation to an electrophilic allenyl iminium species which is susceptible to amine addition g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5baad42eb5698c6d669eee53b2d8137
https://doi.org/10.1002/adsc.201601146
https://doi.org/10.1002/adsc.201601146
Autor:
Guo-Chun Zhou, Binrui Yang, Yuran Peng, Jingjing Li, Shang Li, Maggie Pui Man Hoi, Yicheng Sun, Judy Yuet-Wa Chan, Decai Wang, Simon Ming-Yuen Lee, George P.H. Leung, Bin Huang, Huidong Yu
Publikováno v:
Molecular BioSystems. 13:525-536
The aim of this study is to investigate the anti-angiogenic properties of andrographolide derivatives AGP-26a (12β-isomer), AGP-26b (12α-isomer) and AGP-26 (4 : 1 mixture of AGP-26a and AGP-26b) in vitro and in vivo. Human umbilical vein endothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0675d02cf21b06bed3d4a039c2d77b95
https://doi.org/10.1039/c6mb00641h
https://doi.org/10.1039/c6mb00641h
Autor:
Hui Liu, Tailong Lei, Chao Shen, Dan Li, Xuwen Wang, Xiao-Jun Yao, Huidong Yu, Ercheng Wang, Lei Xu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology
Frontiers in Pharmacology
NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB pathway, has been proved to be an important target for the regulation of the immune system. In the past few years, NIK inhibitors with various scaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2a69568c1862c3224b506cdfda848f
https://www.frontiersin.org/article/10.3389/fphar.2019.00345/full
https://www.frontiersin.org/article/10.3389/fphar.2019.00345/full