Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Huichun Zhu"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 1, Pp o175-o176 (2010)
rac-Benzyl 3-oxohexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate was separated by chiral chromatography, and one of the enantiomers ([α]22D = +10°) was hydrogenated in the presence of Pd/C in methanol, producing octahydro-3H-pyrrolo[3,4-c]pyri
Externí odkaz:
https://doaj.org/article/031d342c717e4216a64d978d82a76d58
Deep semi-supervised learning with contrastive learning and partial label propagation for image data
Publikováno v:
Knowledge-Based Systems. 245:108602
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Autor:
Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v:
Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Publikováno v:
Journal of Memory and Language. 82:86-104
We compared naming patterns for common household objects by monolingual speakers of English and Mandarin and Mandarin-English bilinguals in both their L1 and L2. These bilinguals arrived in the U.S. no earlier than age 15, thus having a well-entrench
Autor:
Sergei Timofeevski, Lars D. Engstrom, Mingying He, Michael R. Collins, Martin Paul Edwards, Phuong Le, Graham L. Smith, John Charles Kath, Helen Y. Zou, Deal Judith G, Ya-Li Deng, Robert Steven Kania, Benjamin J. Burke, Cynthia Louise Palmer, Huichun Zhu, A.E. Stewart, Hieu Lam, Dac M. Dinh, Simon Bailey, Jacqui Elizabeth Hoffman, Neal W. Sach, Robert Louis Hoffman, Qinhua Huang, J. Jean Cui, Alexei Brooun, Wei Liu, Laura Lingardo, Tod Smeal, Ted William Johnson, Michele McTigue, Justine L. Lam, Jinjiang Zhu, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 57:4720-4744
Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive non-small-cell lung carcinoma patients, progression during treatment eventually develops. Resistant patient samples revealed a variety of point mutations in
Autor:
Tod Smeal, Wei Liu, Huichun Zhu, Simon Bailey, Michael R. Collins, A.E. Stewart, Jacqui Elizabeth Hoffman, Lars D. Engstrom, Graham L. Smith, J. Jean Cui, Ya-Li Deng, Benjamin J. Burke, Laura Lingardo, Phuong Le, Andrew Simon Cook, Konstantinos Tsaparikos, Hieu Lam, Jinjiang Zhu, Ted William Johnson, Neal W. Sach, Dac M. Dinh, Robert Louis Hoffman, Mingying He, Hui Wang, Alexei Brooun, Dack Kevin Neil, Qinhua Huang, Sergei Timofeevski, Deal Judith G, Justine L. Lam, Qiuhua Li, Hong Shen, Melissa West Lu, Michele McTigue, Paul F. Richardson, Kevin D. Bunker, Robert Steven Kania, Martin Paul Edwards, Helen Y. Zou, Cynthia Louise Palmer, Patrick S. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 57:1170-1187
Crizotinib (1), an anaplastic lymphoma kinase (ALK) receptor tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration in 2011, is efficacious in ALK and ROS positive patients. Under pressure of crizotinib treatment, point mutations
Autor:
Tran Khanh Tuan, Qiyue Hu, Zhang Junhu, Scott L. Butler, Atsuo Kuki, Qinghai Peng, Erik Jon Flahive, Graham L. Smith, Huichun Zhu, Deepak Dalvie, Plewe Michael Bruno, Jim Solowiej, Dorothy Delisle, Ted William Johnson, Wen Liu, Steven P. Tanis, Klaus Ruprecht Dress, Jon E. Kuehler, Guy A. McClellan, Xiaoming Yu, Hai Wang, Paul F. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 54:3393-3417
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the synthesis of orally bioavailable a
Autor:
Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids
Autor:
Daniel Tyler Richter, Buwen Huang, Cripps Stephan James, Michelle Tran-Dubé, Huichun Zhu, Sutton Scott Channing, Jean Cui, Neal W. Sach
Publikováno v:
ChemInform. 43
The base-mediated treatment of aromatic mesylates with primary and secondary alcohols allows access to a wide range of aryl ethers.