Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Huibert D. Mansvelder"'
Autor:
Bonnie C. Plug, Ilma M. Revers, Marjolein Breur, Gema Muñoz González, Jaap A. Timmerman, Niels R.C. Meijns, Daniek Hamberg, Jikke Wagendorp, Erik Nutma, Nicole I. Wolf, Antonio Luchicchi, Huibert D. Mansvelder, Niek P. van Til, Marjo S. van der Knaap, Marianna Bugiani
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Human brain experimental models recapitulating age- and disease-related characteristics are lacking. There is urgent need for human-specific tools that model the complex molecular and cellular interplay between different cell types to assess
Externí odkaz:
https://doaj.org/article/95f2002b28a24aafa6da02213860ae53
Autor:
Eline J. Mertens, Yoni Leibner, Jean Pie, Anna A. Galakhova, Femke Waleboer, Julia Meijer, Tim S. Heistek, René Wilbers, Djai Heyer, Natalia A. Goriounova, Sander Idema, Matthijs B. Verhoog, Brian E. Kalmbach, Brian R. Lee, Ryder P. Gwinn, Ed S. Lein, Eleonora Aronica, Jonathan Ting, Huibert D. Mansvelder, Idan Segev, Christiaan P.J. de Kock
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114100- (2024)
Summary: Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent
Externí odkaz:
https://doaj.org/article/371ff7956af64d3bbda89f13ea9ec965
Autor:
Stan L. W. Driessens, Anna A. Galakhova, Djai B. Heyer, Isabel J. Pieterse, René Wilbers, Eline J. Mertens, Femke Waleboer, Tim S. Heistek, Loet Coenen, Julia R. Meijer, Sander Idema, Philip C. de Witt Hamer, David P. Noske, Christiaan P. J. de Kock, Brian R. Lee, Kimberly Smith, Jonathan T. Ting, Ed S. Lein, Huibert D. Mansvelder, Natalia A. Goriounova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and mig
Externí odkaz:
https://doaj.org/article/50832097a77b45fca91162348467e082
Autor:
Christina F. de Veij Mestdagh, Frank Koopmans, Jonathan C. Breiter, Jaap A. Timmerman, Pieter C. Vogelaar, Guido Krenning, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide and remains without effective cure. Increasing evidence is supporting the mitochondrial cascade hypothesis, proposing that loss of mitochondrial
Externí odkaz:
https://doaj.org/article/57d2e632022d4d42b3829a94237d7099
Autor:
Qianliang Li, Ricarda F. Weiland, Ivana Konvalinka, Huibert D. Mansvelder, Tobias S. Andersen, Dirk J. A. Smit, Sander Begeer, Klaus Linkenkaer-Hansen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract There is broad interest in discovering quantifiable physiological biomarkers for psychiatric disorders to aid diagnostic assessment. However, finding biomarkers for autism spectrum disorder (ASD) has proven particularly difficult, partly due
Externí odkaz:
https://doaj.org/article/89e1c75216ec426694127594cb92e431
Autor:
Christina F. de Veij Mestdagh, Jaap A. Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S. M. Miedema, Maaike Goris, Rolinka J. van der Loo, Guido Krenning, Ka Wan Li, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains larg
Externí odkaz:
https://doaj.org/article/79d911a2ec34496183b119acd53c6f51
Autor:
Christiaan P. J. de Kock, Jean Pie, Anton W. Pieneman, Rebecca A. Mease, Arco Bast, Jason M. Guest, Marcel Oberlaender, Huibert D. Mansvelder, Bert Sakmann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
In order to investigate the information encoded by spiking activity in different neuronal cell types in the primary somatosensory cortex, de Kock et al performed electrophysiological recordings in untrained rats. They demonstrated that an increase in
Externí odkaz:
https://doaj.org/article/545cc6b7f83a4daf9de820113342a7e0
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104641- (2022)
Summary: The basilar pontine nuclei (bPN) are known to receive excitatory input from the entire neocortex and constitute the main source of mossy fibers to the cerebellum. Various potential inhibitory afferents have been described, but their origin,
Externí odkaz:
https://doaj.org/article/3eb277d31c974c158622f2add9241669
Autor:
Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier, Alexandra R. van den Berg, Antonio Luchicchi, Rogier Min, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
This study presents an anatomical, neurophysiological and functional characterization of four distinct prefrontal populations that project to striatal and thalamic sub-regions. The authors show that each of these populations have a discrete role in t
Externí odkaz:
https://doaj.org/article/17bef0b137494ed7848e3fdce6586f9f
Autor:
Erika L. Juarez-Martinez, Dorinde M. van Andel, Jan J. Sprengers, Arthur-Ervin Avramiea, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen, Hilgo Bruining
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair GA
Externí odkaz:
https://doaj.org/article/c91bd09be3bd41ee9453fca40b44cccc