An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

Autor: Yi-Hsiang Hsu, M Carola Zillikens, Scott G Wilson, Charles R Farber, Serkalem Demissie, Nicole Soranzo, Estelle N Bianchi, Elin Grundberg, Liming Liang, J Brent Richards, Karol Estrada, Yanhua Zhou, Atila van Nas, Miriam F Moffatt, Guangju Zhai, Albert Hofman, Joyce B van Meurs, Huibert A P Pols, Roger I Price, Olle Nilsson, Tomi Pastinen, L Adrienne Cupples, Aldons J Lusis, Eric E Schadt, Serge Ferrari, André G Uitterlinden, Fernando Rivadeneira, Timothy D Spector, David Karasik, Douglas P Kiel

Publikováno v: PLoS Genetics, Vol 6, Iss 6, p e1000977 (2010)

Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic v

Externí odkaz: https://doaj.org/article/7414bd8447c549e0bee8cafe4d14b403

Correction: Large-Scale Evidence for the Effect of the Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study.

Autor: Stuart H Ralston, André G Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L Langdahl, Paul Lips, Roman Lorenc, Barbara Obermayer-Pietsch, Serena Scollen, Mariona Bustamante, Lise Bjerre Husted, Alisoun H Carey, Adolfo Diez-Perez, Alison M Dunning, Alberto Falchetti, Elzbieta Karczmarewicz, Marcin Kruk, Johannes P. T. M van Leeuwen, Joyce B. J van Meurs, Jon Mangion, Fiona E. A McGuigan, Leonardo Mellibovsky, Francesca del Monte, Huibert A. P Pols, Jonathan Reeve, David M Reid, Wilfried Renner, Fernando Rivadeneira, Natasja M van Schoor, Rachael E Sherlock, John P. A Ioannidis

Publikováno v: PLoS Medicine, Vol 3, Iss 5 (2006)

Externí odkaz: https://doaj.org/article/d533184ce5314ba9985c7ffd9b2c1be5

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS

Autor: André G. Uitterlinden, Huibert A. P. Pols, Johannes P.T.M. van Leeuwen, Bram C. J. van der Eerden, Natalia Campos-Obando, Albert Hofman, W. Nadia H. Koek, Elizabeth R. Hooker, Carrie M. Nielson, M. Carola Zillikens

Publikováno v: Journal of Bone and Mineral Research. 32:1182-1193

Extreme phosphate levels (P) have been associated with mineralization defects and increased fracture risk. Whether P within normal range is related to bone health in the general population is not well understood. To investigate the association of P w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a78d351749fa2f96e0508266655c5019
https://doi.org/10.1002/jbmr.3094

Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention

Autor: Nuno Pires, Arnoud van der Laarse, Huibert A. P. Pols, André G. Uitterlinden, Moniek P.M. de Maat, Rune R. Frants, PS Monraats, Aeilko H. Zwinderman, Paul H.A. Quax, Douwe Pons, Johannes Waltenberger, Pieter A. Doevendans, J. Wouter Jukema, Robbert DeWinter, Yue Fang, René A. Tio, Ernst E. van der Wall

Publikováno v: Expert opinion on therapeutic targets, 14(3), 243-251. Taylor and Francis Ltd.
Expert Opinion on Therapeutic Targets, 14(3), 243-251. Informa Healthcare
Expert Opinion on Therapeutic Targets, 14(3), 243-251. Taylor & Francis Ltd
Expert Opinion on Therapeutic Targets, 14(3), 243-251
EXPERT OPINION ON THERAPEUTIC TARGETS, 14(3), 243-251. TAYLOR & FRANCIS LTD

Objective: Restenosis is the main drawback of percutaneous coronary intervention (PCI). Inherited factors may explain part of the risk of restenosis. Recently, the vitamin D receptor (VDR) has been shown to be involved not only in bone metabolism but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95422790b31d3eee67f726d8ba9e791
https://doi.org/10.1517/14728220903520929

A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density

Autor: Johannes P.T.M. van Leeuwen, Qiuju Huang, Huibert A. P. Pols, Albert Hofman, Cornelia M. van Duijn, Paul L A van Daele, André G. Uitterlinden, Jan C. Birkenhäger, H. Burger

Publikováno v: Journal of Bone and Mineral Research, 11(9), 1241-1248. Wiley-Blackwell

Conflicting results have been reported on the association between restriction fragment length polymorphisms (RFLPs) at the vitamin D receptor (VDR) gene locus (i.e., for BsmI, ApaI, and TaqI) and bone mineral density (BMD). We analyzed this associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa11a831b9a43fbe30cc1142e109f5c
https://doi.org/10.1002/jbmr.5650110908