Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Hui-kuan Lin"'
Autor:
Tingjin Chen, Hui-Kuan Lin
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102815- (2024)
Summary: RNA 5-methylcytosine (m5C) modification critically impacts many biological processes. Here, we provide a protocol to analyze the role of various metabolites in impacting global RNA m5C levels in cultured cells by dot blot. We describe steps
Externí odkaz:
https://doaj.org/article/5767c0322b1c4e1ba44aed5ff52b5a8d
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background It is unclear which core events drive the malignant progression of gliomas. Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. This study was designed to investigate
Externí odkaz:
https://doaj.org/article/de584d31b4014daaa7f0aefe61aebee6
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-17 (2022)
Abstract Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player transmitti
Externí odkaz:
https://doaj.org/article/bc9f92b054754c75b6d54ecc2ddc4f20
Autor:
Kojo Agyemang, Allan M. Johansen, Grayson W. Barker, Michael J. Pennison, Kimberly Sheffield, Hugo Jimenez, Carl Blackman, Sambad Sharma, Patrick A. Fordjour, Ravi Singh, Katherine L. Cook, Hui-Kuan Lin, Wei Zhang, Hui-Wen Lo, Kounosuke Watabe, Peiqing Sun, Carl D. Langefeld, Boris Pasche
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract There is growing evidence that germline mutations in certain genes influence cancer susceptibility, tumor evolution, as well as clinical outcomes. Identification of a disease-causing genetic variant enables testing and diagnosis of at-risk i
Externí odkaz:
https://doaj.org/article/ec05d9e90f1e4859b2ee3178f946df8a
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101940- (2023)
Summary: Here, we present optimized approaches to identify the efficiency of cancer cell phagocytosis by macrophages in vitro and in vivo. We describe the preparation and co-culture of macrophages and cancer cells, followed by in vitro phagocytosis a
Externí odkaz:
https://doaj.org/article/cd48d86fd8b84880b9210c98ad7fe34b
Retraction Note: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
Autor:
Gui-fang Zhu, Yang-wei Xu, Jian Li, Hui-lin Niu, Wen-xia Ma, Jia Xu, Pei-rong Zhou, Xia Liu, Dan-li Ye, Xiao-rong Liu, Tao Yan, Wei-ke Zhai, Zhi-jun Xu, Chun Liu, Lei Wang, Hao Wang, Jia-mao Luo, Li Liu, Xuan-qi Li, Suiqun Guo, Hui-ping Jiang, Peng Shen, Hui-kuan Lin, Di-hua Yu, Yan-qing Ding, Qing-ling Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/cd9207c07ef1431d916b21d2494179fe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The ubiquitination of SKP2, an oncoprotein, is controlled by its E3 ligases, including APC/CFZR1 and deubiquitinases such as USP10. We identified a two-gene signature for the ubiquitination of SKP2, consisting of the copy number of FZR1 comp
Externí odkaz:
https://doaj.org/article/1149c03f182b47339501a7bdd90c293f
Autor:
Allison K. Meyers, Zhan Wang, Wenzheng Han, Qingxia Zhao, Manal Zabalawi, Likun Duan, Juan Liu, Qianyi Zhang, Rajesh K. Manne, Felipe Lorenzo, Matthew A. Quinn, Qianqian Song, Daping Fan, Hui-Kuan Lin, Cristina M. Furdui, Jason W. Locasale, Charles E. McCall, Xuewei Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111941- (2023)
Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) signif
Externí odkaz:
https://doaj.org/article/9e44575ee34a4202a7a3e462e4561170
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101385- (2022)
Summary: Metabolites are not only substrates in metabolic reactions, but they also serve as signaling molecules to regulate diverse biological functions. Identification of the binding proteins for the metabolites helps in the understanding of their f
Externí odkaz:
https://doaj.org/article/54131d634b1646018287ef4db87219f4
Autor:
Chuan Xu, Guoxiang Jin, Hong Wu, Wei Cui, Yu-Hui Wang, Rajesh Kumar Manne, Guihua Wang, Weina Zhang, Xian Zhang, Fei Han, Zhen Cai, Bo-Syong Pan, Che-Chia Hsu, Yiqiang Liu, Anmei Zhang, Jie Long, Hongbo Zou, Shuang Wang, Xiaodan Ma, Jinling Duan, Bin Wang, Weihui Liu, Haitao Lan, Qing Xiong, Gang Xue, Zhongzhu Chen, Zhigang Xu, Mark E. Furth, Sarah Haigh Molina, Yong Lu, Dan Xie, Xiu-Wu Bian, Hui-Kuan Lin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Cancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade immune cell killing and promote tumor progression. Here we showed that signal regulatory protein γ (SIRPγ) determined CSLC properties and immune evasiveness in a s
Externí odkaz:
https://doaj.org/article/ed9d232ee19b4520b69e25795aaa76fb