Výsledky vyhledávání

Akademický článek

Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead

Autor: Hui-yu Li, Wei-liang Qi, Yu-xiang Wang, Ling-hua Meng

Publikováno v: Genes and Diseases, Vol 10, Iss 2, Pp 403-414 (2023)

KRAS is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been challenging. Among the different known mutants, KRasG12C has been proved to be successfully targeted recently. Several covalent inhib

Externí odkaz: https://doaj.org/article/09bdeec9edda49418dc07d81e674db4c

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Akademický článek

Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)

Abstract Metabolic reprogramming plays important roles in development and progression of nasopharyngeal carcinoma (NPC), but the underlying mechanism has not been completely defined. In this work, we found INSL5 was elevated in NPC tumor tissue and t

Externí odkaz: https://doaj.org/article/621a29cd73654baba154f0c200991840

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Akademický článek

Therapeutic Effect and Mechanism of Si-Miao-Yong-An-Tang on Thromboangiitis Obliterans Based on the Urine Metabolomics Approach

Autor: Hui-Yu Li, Hui Sun, Ai-Hua Zhang, Lu-Wen He, Shi Qiu, Jun-Ru Xue, Fangfang Wu, Xi-Jun Wang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Si-Miao-Yong-An-Tang (SMYAT) is a classic prescription for the treatment of thromboangiitis obliterans (TAO). However, the effect and mechanism are still unclear. This experiment aims to evaluate the therapeutic effect and mechanism of SMYAT on sodiu

Externí odkaz: https://doaj.org/article/3975381676de43e1878248b421378df4

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Dissertation/ Thesis

A Study of Relationship among Corporate Social Responsibility, Corporate Governance, Intangible Assets and Financial Performance

Autor: Hui-Yu Li, 李蕙羽

101
Implementing corporate social responsibility, improving financial performance and strengthening corporate governance mechanism and intangible assets are all indispensable to a business management now. The main purpose of this research is to

Externí odkaz: http://ndltd.ncl.edu.tw/handle/53351257607708566987

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Dissertation/ Thesis

An internal location selection model for a single firm's supply chain.

Autor: Hui-Yu Li, 李蕙娛

96
Global logistics management has become trend of enterprise management nowadays. On the basis of getting maximal profits, to select preponderant location for manufacturer and shopkeeper is the efficient means to implement global logistics mana

Externí odkaz: http://ndltd.ncl.edu.tw/handle/06523580669190336415

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Dissertation/ Thesis

The Impacts of Expatriate Selection Criteria on Organizational Performance in Subsidiaries of Transnational Corporate

Autor: Hui-Yu Li, 李慧瑜

96
The demands for corporate expatiation increase in a large scale due to the rapid and prosperous growth of global economy for recent years. This has been causing how to recruit and select suitable and qualified candidates for expatiation for i

Externí odkaz: http://ndltd.ncl.edu.tw/handle/19155149209517164591

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Dissertation/ Thesis

A theoretical study of the reaction of C(3P)with cyanoacetylene

Autor: Hui-Yu Li, 黎慧瑜

93
1 The reactions of carbon atom in its triplet ground state, C(3P), with the unsaturated nitriles, cyanoacetylene (HCCCN), is investigated theoretically to explore possible pathways for the formation of carbon-nitrogen-bearing species in a

Externí odkaz: http://ndltd.ncl.edu.tw/handle/46613570606709969873

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