Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hui-Rong Shen"'
Autor:
Wanding Zhou, Minmin Liu, Kirsten Grønbæk, Yang W. Zhang, Andreas Due Ørskov, Peter A. Jones, Stephen B. Baylin, Hui-Rong Shen, Gangning Liang, Hitoshi Ohtani, Jessica Charlet
Publikováno v:
Proceedings of the National Academy of Sciences. 113:10238-10244
Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fa1e036d9b256cc083752018f5b356
https://doi.org/10.1073/pnas.1612262113
https://doi.org/10.1073/pnas.1612262113
Publikováno v:
Advanced Drug Delivery Reviews. 54:1041-1048
Poly(ortho esters), POE, are synthetic bioerodible polymers that can be prepared as solid materials, or as viscous, injectable polymers. These materials have evolved through a number of families, and the latest member of this family, POE IV, is parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d7f1f58e0dd282bb4ff1035f9145b1
https://doi.org/10.1016/s0169-409x(02)00056-x
https://doi.org/10.1016/s0169-409x(02)00056-x
Autor:
Hui-Rong Shen, Robert Gurny, Alexandra Rothen-Weinhold, Marco van de Weert, Steve Ng, John Barr, Jorge Heller, Khadija Schwach-Abdelaoui
Publikováno v:
Journal of Controlled Release, Vol. 78, No 1-3 (2002) pp. 133-141
The preparation of drug delivery devices using solventless fabrication procedures is of significant interest and two such procedures are described. In one such procedure, powdered polymer and micronized protein are intimately mixed and then extruded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bd537cc8db275a59600d4e0334bef1
https://doi.org/10.1016/s0168-3659(01)00482-5
https://doi.org/10.1016/s0168-3659(01)00482-5
Autor:
Robert Gurny, John Barr, Alexandra Rothen-Weinhold, Jorge Heller, Hui-Rong Shen, Steven Y. Ng
Publikováno v:
Macromolecular Symposia. 172:67-72
Poly(ortho ester) rods containing 15 wt% FITC-BSA were prepared by extruding an intimate mixture of finely powdered polymer and protein at a temperature where protein activity is retained. After an induction period, linear in vitro release kinetics w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f10e95b8396ce13595b164c8db1cf13
https://doi.org/10.1002/1521-3900(200107)172:1<67::aid-masy67>3.0.co
https://doi.org/10.1002/1521-3900(200107)172:1<67::aid-masy67>3.0.co
Autor:
S.Y. Ng, Hui-Rong Shen, K. Schwach-Abdellaoui, Alexandra Rothen-Weinhold, Robert Gurny, John Barr, J. Heller
Publikováno v:
Journal of Controlled Release. 71:31-37
A solventless procedure was used where powdered polymer and micronized protein were intimately mixed and then extruded into 1 mm strands that were cut to the desired length. The polymers used were poly(ortho esters) specifically designed to allow ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be047c7fa594eb656f646915ebe7d570
https://doi.org/10.1016/s0168-3659(00)00348-5
https://doi.org/10.1016/s0168-3659(00)00348-5
Publikováno v:
Journal of Photochemistry and Photobiology A: Chemistry. 133:115-122
Some types of proteins are intermolecularly cross-linked via the formation of Tyr–Tyr (dityrosine) bonds on illumination in the presence of certain kinds of photosensitizers. The study of reactions of this type is of importance since they appear to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3423bc70e71836c4d256689fb2edcc
https://doi.org/10.1016/s1010-6030(00)00228-8
https://doi.org/10.1016/s1010-6030(00)00228-8
Publikováno v:
Photochemistry and Photobiology. 70:130-137
As part of a study on the role of Tyr residues in the photosensitized intermolecular crosslinking of proteins, we have surveyed the kinetics of the rose bengal- and flavin mononucleotide (FMN)-sensitized photooxidation and crosslinking of a water-sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cf8fa8bceaa421804b1ed1a68334d5e
https://doi.org/10.1111/j.1751-1097.1999.tb07980.x
https://doi.org/10.1111/j.1751-1097.1999.tb07980.x
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 35:213-219
Illumination of bovine pancreatic ribonuclease A (RNase A) in solution in the presence of rose bengal as a photosensitizer resulted in the progressive formation of enzyme dimers, trimers, tetramers and higher oligomers, as measured by gel electrophor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61005e9a531dbed88ab9efccd26cfc
https://doi.org/10.1016/s1011-1344(96)07300-9
https://doi.org/10.1016/s1011-1344(96)07300-9
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 34:203-210
One of the mechanisms by which cells might be damaged during the photodynamic therapy (PDT) of tumors is via the covalent crosslinking of proteins to proteins or to other molecules in the cell. It has been suggested that photodynamically generated si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030e96637574cd434facce9d950b25e0
https://doi.org/10.1016/1011-1344(96)07286-7
https://doi.org/10.1016/1011-1344(96)07286-7
Autor:
Lauren Hamilton, Rene Onrust, Thomas Neil Wheeler, Charles Prince Zuta, Sasha Gragerov, Alex Rohde, Shawn McKee, Neil S. Cutshall, Jennifer Lynn Gage, Vince Florio, Harbol Kevin L, Galina Gragerova, Hui-Rong Shen
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86d367c4f6331c08078f09eadeaaf6b
https://pubmed.ncbi.nlm.nih.gov/22841436
https://pubmed.ncbi.nlm.nih.gov/22841436