Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hui-Qiang Q. Zhou"'
Autor:
David Barrett, Stacey T. Long, Francis X. Tavares, David N. Deaton, Lois L. Wright, Hui-Qiang Q. Zhou, Vicente Samano, John G. Catalano, Kevin J. Wells-Knecht, Aaron B. Miller, Robert B. McFadyen, Larry R. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:22-27
Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2–P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavaila
Autor:
Kevin J. Wells-Knecht, David Barrett, John G. Catalano, David N. Deaton, Lois L. Wright, Larry R. Miller, Hui-Qiang Q. Zhou, Francis X. Tavares, Stacey T. Long
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2543-2546
An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P1′ elements led to enhancements in solubility and permeability. T
Autor:
Jennifer Poole Peckham, Wendy Y. Mills, Terrence L. Smalley, Jayme Lyn Roark Wilson, Andrew J. Peat, Scott Howard Dickerson, Tony Y. Wang, Dulce Garrido, Stephanie L. Schweiker, Hui-Qiang Q. Zhou, Frank Preugschat, Joyce A. Boucheron, Stephen A. Thomson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2121-2125
A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1)
Autor:
J. Alan Payne, John A. Ray, Stacey T. Long, Robert B. McFadyen, Hui-Qiang Q. Zhou, John G. Catalano, Lois L. Wright, Aaron B. Miller, Derril H. Willard, Vicente Samano, Jurgensen Cynthia Holder, Anne M. Hassell, Kevin J. Wells-Knecht, David N. Deaton, Francis X. Tavares, Lisa M. Shewchuk, Larry R. Miller, Virginia M. Boncek, David Barrett
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(15)
An orally bioavailable series of ketoamide-based cathepsin K inhibitors with good pharmacokinetic properties has been identified. Starting from a potent inhibitor endowed with poor drug properties, conformational constraint of the P2-P3 linker and mo