Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hui-May Chu"'
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
Niels D. Prins, John E. Harrison, Hui-May Chu, Kelly Blackburn, John J. Alam, Philip Scheltens, for the REVERSE-SD Study Investigators
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background In preclinical studies, p38⍺ kinase is implicated in Alzheimer’s disease (AD) pathogenesis. In animal models, it mediates impaired synaptic dysfunction in the hippocampus, causing memory deficits, and is involved in amyloid-be
Externí odkaz:
https://doaj.org/article/ba07cc40f2b24610881dc152be303974
Autor:
Alam, John J., Maruff, Paul, Doctrow, Susan R., Hui-May Chu, Conway, Jennifer, Gomperts, Stephen N., Teunissen, Charlotte
Publikováno v:
Neurology; 10/24/2023, Vol. 101 Issue 17, pe1708-e1717, 10p
Autor:
Philip Scheltens, Bart N.M. van Berckel, Maqsood Yaqub, Niels D. Prins, John Alam, Hui May Chu, Alle Meije Wink, Alida A. Gouw, Adriaan A. Lammertsma
Publikováno v:
Annals of Clinical and Translational Neurology, 5(4), 464-473. John Wiley and Sons Ltd
Annals of Clinical and Translational Neurology
Scheltens, P, Prins, N, Lammertsma, A, Yaqub, M, Gouw, A, Wink, A M, Chu, H M, van Berckel, B N M & Alam, J 2018, ' An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease ', Annals of Clinical and Translational Neurology, vol. 5, no. 4, pp. 464-473 . https://doi.org/10.1002/acn3.549
Annals of Clinical and Translational Neurology
Scheltens, P, Prins, N, Lammertsma, A, Yaqub, M, Gouw, A, Wink, A M, Chu, H M, van Berckel, B N M & Alam, J 2018, ' An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease ', Annals of Clinical and Translational Neurology, vol. 5, no. 4, pp. 464-473 . https://doi.org/10.1002/acn3.549
Objective: The aim of this study was to preliminarily evaluate an oral small molecule p38α kinase inhibitor in patients with early Alzheimer's disease (AD) for the effects on brain amyloid plaque load and episodic memory function, and to establish p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5140df8178fe4830c458040afb9636f
https://doi.org/10.1002/acn3.549
https://doi.org/10.1002/acn3.549
Publikováno v:
Epilepsy research. 157
To describe the use of a population pharmacokinetic (PopPK) model incorporating weight and ontogeny to identify effective clobazam (CLB) dosing for use in a clinical trial in pediatric patients with Dravet syndrome.Pharmacokinetic data were combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654470ca3a765f656ec57e77ef90156
https://pubmed.ncbi.nlm.nih.gov/31563030
https://pubmed.ncbi.nlm.nih.gov/31563030
Autor:
Wendell R. Su, Robert J. Saphirstein, Brad J. Hogan, Grannum R. Sant, Thiagarajan Meyyappan, Andrew Min, Delaney Berger, Ashok C. Chander, Nikhil Joshi, Matthew J. Whitfield, Michael S. Manak, Nicolai Steinke, Kevin B. Knopf, Gauri Dixit, Hui-May Chu, Jonathan S. Varsanik, David M. Albala
The risk stratification of prostate cancer and breast cancer tumours from patients relies on histopathology, selective genomic testing, or on other methods employing fixed formalin tissue samples. However, static biomarker measurements from bulk fixe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163d36a5e0a411eb41eea5ebb8bfc0be
https://europepmc.org/articles/PMC6407716/
https://europepmc.org/articles/PMC6407716/
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3ff1b41186b5e9f79b68f91ce3be13
https://doi.org/10.1016/j.jalz.2018.06.695
https://doi.org/10.1016/j.jalz.2018.06.695
Publikováno v:
The Journal of Clinical Pharmacology. 56:365-374
A metabolic mechanism-based characterization of antiepileptic drug-drug interactions (DDIs) with clobazam in patients with Lennox-Gastaut syndrome (LGS) was performed using a population pharmacokinetic (PPK) approach. To characterize potential DDIs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea099ce8ee9245b6f308da90ff525819
https://doi.org/10.1002/jcph.603
https://doi.org/10.1002/jcph.603
Publikováno v:
The Journal of Clinical Pharmacology. 56:213-222
An integrative population pharmacokinetics (PPK)-based approach was used to characterize the effect of hepatic impairment on clobazam PK and its major metabolite in systemic circulation, N-desmethylclobazam (N-CLB). At therapeutic clobazam dosages, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8e61b0918b0d6f25df400404446f83
https://doi.org/10.1002/jcph.586
https://doi.org/10.1002/jcph.586
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0603b6e143012f881c645aed4e9d7c7
https://doi.org/10.1016/j.jalz.2017.07.197
https://doi.org/10.1016/j.jalz.2017.07.197