Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hui-Ling Yap"'
Autor:
Richie Soong, Samuel Guan Wei Ow, Soo-Chin Lee, Kar Tong Tan, Nur Sabrina Sapari, Pei Yi Ong, Henry Yang, Hui-Ling Yap
Publikováno v:
Clinical Colorectal Cancer. 18:e324-e334
Background Although at least 5 genes are implicated in Lynch Syndrome (LS), up to 50% of suspected cases are owing to undefined genes. We utilized next generation sequencing (NGS) to characterize the mutation profile of patients with cancer (CA) susp
Autor:
Hui Ling Yap, Xiao Han, Yik Ying Teo, Eiram Elahi, Thomas P. Klemm, Touati Benoukraf, Barry Iacopetta, Richie Soong, Marie Loh, Hong Kiat Ng, Nur Sabrina Sapari, Mengchu Wu, Brendan Pang, Soo-Chin Lee
Publikováno v:
Clinical Chemistry. 60:1549-1557
BACKGROUND Next generation sequencing (NGS) promises many benefits for clinical diagnostics. However, current barriers to its adoption include suboptimal amenability for low clinical throughputs and uncertainty over data accuracy and analytical proce
Autor:
Chiung-Ing Wong1, Hui-Ling Yap1, Seng-Gee Lim2, Jia-Yi Guo1, Boon-Cher Goh1, Soo-Chin Lee soo_chin_lee@nuh.com.sg
Publikováno v:
Hepatology Research. Aug2008, Vol. 38 Issue 8, p838-841. 4p. 1 Diagram, 1 Chart.
Autor:
Soo-Chin Lee, Andrea Li Ann Wong, Fan Lu, How Sung Lee, Thomas I Peng Soh, Richie Soong, Pei Jye Voon, Boon Cher Goh, Nur Sabrina Sapari, Hui Ling Yap, Cho-Yee-Thu Ma
Publikováno v:
British Journal of Clinical Pharmacology. 75:1497-1505
Aims Aldo-ketoreductases have been implicated in the metabolism of doxorubicin. We sought to assess the influence of AKR1C3 genetic variants on doxorubicin metabolism. Methods We sequenced AKR1C3 exon 5 and genotyped seven functional single nucleotid
Autor:
Lingzhi Wang, Soo-Chin Lee, Elaine Zh Seah, Bee Choo Tai, Peter Ang, Yi-Wan Lim, Hui-Ling Yap, Boon Cher Goh, Nan-Soon Wong, Wee-Lee Yeo, Benjamin Chuah, Robert Lim
Publikováno v:
Pharmacogenetics and Genomics. 21:760-768
Objectives Vorinostat, a histone deacetylase inhibitor being actively evaluated in solid tumors, is metabolized by UGT2B17. UGT2B17 null genotype (UGT2B17*2) has been shown in vitro to reduce UGT2B17 activity. This variant is common in Asians but rar
Autor:
Shuk In Tong, Diana Fransiska, John E. Connolly, Soo-Chin Lee, Gloria Chan, Huey Yen Chia, Natalie Ngoi, Samuel Guan Wei Ow, Veonice Bijin Au, Andrea Li Ann Wong, Yvonne Li'en Ang, Rathi Mahendran, Lim Siew Eng, Joan Choo, Bee Choo Tai, Hui-Ling Yap, Ednajoy Ngo, Boon Cher Goh, Maria Jannet Mogro, Germaine Yee
Publikováno v:
Journal of Clinical Oncology. 36:e12571-e12571
e12571Background: Exercise has been shown to have a positive impact on breast cancer survival, but the mechanisms are unclear. Methods: We performed a randomized trial to prospectively study the im...
Autor:
Norita Sukri, Xin Xu, Hui Ling Yap, Soo Chin Lee, Wee-Lee Yeo, Patrick Tan, Yi-Wan Lim, Boon Cher Goh, Philip Iau, Howard L. McLeod, Siew-Eng Lim, Sing-Huang Tan
Publikováno v:
Pharmacogenetics and Genomics. 19:181-192
Studying chemotherapy-induced gene expression changes in vivo, which could provide insights into mechanisms of chemotherapy resistance.We analyzed and compared tumor gene expression changes of about 38 500 genes before and 3 weeks after doxorubicin o
Autor:
Soo Chin Lee, Ross A. Soo, Wei-Shieng Chieng, Jasmine Rui-Chen Lim, Jia-Yi Guo, Robert Lim, Hui-Ling Yap
Publikováno v:
Familial Cancer. 8:85-94
Lynch syndrome is an autosomal dominant disorder due to mutations in DNA mismatch repair genes, causing young onset colorectal cancer and extra-colonic cancers such as endometrial and stomach cancers. We genotyped MLH1 and MSH2 in patients suspected
Autor:
Hui-Boon Khor, Johannes Oldenburg, Hui-Ling Yap, Soo-Chin Lee, Kheng-Siang Ng, Tiong-Cheng Yeo, Pei-Yi Chong, Sheila Clare Rankin, Jia-Yi Guo, Richie Soong, Swee-Siang Ng, Simone Rost, Boon Cher Goh
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:197-205
Background Chinese and Malay subjects have been reported to require less maintenance warfarin than Indians that could not be accounted for by cytochrome P450 (CYP) 2C9 variants. Vitamin K epoxide reductase complex 1 (VKORC1) is the target enzyme of w
Autor:
Soo-Chin Lee, Raghav Sundar, Rozita Abdul Malik, Xiao Wen Lee, Jingshan Ho, Chee Seng Tan, Angela Pang, Anand D. Jeyasekharan, Yi Wan Lim, Nesaretnam Barr Kumarakulasinghe, Samuel Guan Wei Ow, Hui-Ling Yap, Boon Cher Goh, Bee Choo Tai, Kok Yong Seng, Wan Zamaniah Wan Ishak, Lingzhi Wang, Robert John Walsh, Gwo Fuang Ho, Andrea Li Ann Wong
Publikováno v:
Journal of Clinical Oncology. 35:1056-1056
1056 Background: The active metabolite of Exe, 17-dihydroexemestane (17DhExe), is glucuronidated by UGT2B17 to inactive exemestane-17-O-glucuronide (Exe17- O-glu). UGT2B17*2/*2null genotype is 7 times more common in Asians than Caucasians and leads t