Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hui-Kai Kuo"'
Autor:
Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev, Farshad Guirakhoo
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2724-2734 (2022)
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike p
Externí odkaz:
https://doaj.org/article/d9e5af23b5ef47048009e734003b47bf
Autor:
Chang Yi Wang, Kao-Pin Hwang, Hui-Kai Kuo, Wen-Jiun Peng, Yea-Huei Shen, Be-Sheng Kuo, Juin-Hua Huang, Hope Liu, Yu-Hsin Ho, Feng Lin, Shuang Ding, Zhi Liu, Huan-Ting Wu, Ching-Tai Huang, Yuarn-Jang Lee, Ming-Che Liu, Yi-Ching Yang, Po-Liang Lu, Hung-Chin Tsai, Chen-Hsiang Lee, Zhi-Yuan Shi, Chun-Eng Liu, Chun-Hsing Liao, Feng-Yee Chang, Hsiang-Cheng Chen, Fu-Der Wang, Kuo-Liang Hou, Jennifer Cheng, Min-Sheng Wang, Ya-Ting Yang, Han-Chen Chiu, Ming-Han Jiang, Hao-Yu Shih, Hsuan-Yu Shen, Po-Yen Chang, Yu-Rou Lan, Chi-Tian Chen, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Yu-Chi Chou, Mary Kate Morris, Carl V. Hanson, Farshad Guirakhoo, Michael Hellerstein, Hui-Jing Yu, Chwan-Chuen King, Tracy Kemp, D. Gray Heppner, Thomas P. Monath
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Background The Delta and Omicron variants of SARS-CoV-2 are currently responsible for breakthrough infections due to waning immunity. We report phase I/II trial results of UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein and rational
Externí odkaz:
https://doaj.org/article/6d6f293c98474b5f96a331e81908a684
Autor:
Hui-Kai Kuo, 郭惠凱
93
Bidens pilosa is claimed to be beneficial for immune, anti-inflammatory disorders or diabetes; however, little scientific evidence has been provided concerning its function. We conducted an ovalbumin sensitization animal model to address the
Bidens pilosa is claimed to be beneficial for immune, anti-inflammatory disorders or diabetes; however, little scientific evidence has been provided concerning its function. We conducted an ovalbumin sensitization animal model to address the
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/83794957266622437989
Autor:
Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui Kai Kuo, Wen Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt
Publikováno v:
The Journal of infectious diseases. 226(8)
The highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has caused high rates of breakthrough infections in those previously vaccinated with ancestral strain coronavirus disease 2019 (COVID-19) vaccines.
Autor:
Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P. Monath, Alexander Rumyantsev, David Goldblatt
The highly transmissible Omicron variant has caused high rates of breakthrough infections among vaccinated and convalescent individuals. Here, we demonstrate that a booster dose of UB-612 vaccine candidate delivered 7-9 months after primary vaccinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6cb60e04ad280204aec0f69159c0c10
https://doi.org/10.1101/2022.03.18.484436
https://doi.org/10.1101/2022.03.18.484436
Autor:
Farshad Guirakhoo, Chang Yi Wang, Chwan-Chuen King King, Mary Kate Morris, Yu-Hsin Ho, Thomas P. Monath, Jennifer Cheng, Ming-Han Jiang, Michael Hellerstein, Kao-Pin Hwang, Yu-Rou Lan, Donald Gray Heppner, Tracy Kemp, Jian-Jong Liang, Sky Chen, Min-Sheng Wang, Po-Yen Chang, Feng Lin, Chun-Che Liao, Shuang Ding, Hui-Kai Kuo, Carl V. Hanson, Hsuan-Yu Shen, Huang-Ting Wu, Mei Mei Hu, Ya-Ting Yang, Hui-Jiing Yu, Yi-Ling Lin, Daphne Shen, Kuo-Liang Hou, Be-Sheng Kuo, Zhi Liu, Han Chen Chiu, Yu-Chi Chou, Hao-Yu Shih, Juin-Hua Huang, James Peng, Hope Liu
SARS-CoV-2 breakthrough infection occurs due to waning immunity time-to-vaccine, to which the globally-dominant, highly-contagious Delta variant is behind the scene. In the primary 2-dose and booster series of clinical Phase-1 trial, UB-612 vaccine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::446393e31c0c93346ad08ba201589297
https://doi.org/10.21203/rs.3.rs-944205/v1
https://doi.org/10.21203/rs.3.rs-944205/v1
Autor:
Li Li Chiu, Der-Yuan Chen, Chia Yu Yang, Joung-Liang Lan, Hongbo Hu, Hui Kai Kuo, Xiaohong Wang, Gregory A. Dement, Tse-Hua Tan, Ju Pi Li
Publikováno v:
Journal of Biological Chemistry. 287:11037-11048
Hematopoietic progenitor kinase 1 (HPK1) is a Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity. B cell receptor (BCR) signaling activates HPK1 by inducing BLNK/HPK1 interaction. Whether HPK1 can reciprocally regula
Publikováno v:
Cancer Research. 67:11914-11923
B lymphocyte–induced maturation protein-1 (Blimp-1) is a transcriptional repressor that plays an important role during plasmacytic differentiation and is expressed in normal and transformed plasma cells. We here investigated the importance of conti
Autor:
Kuo-I Lin, Yeong-Yi Kao, Alice L. Yu, Chi-Huey Wong, Hui-Kai Kuo, Wen-Bin Yang, Hsin-Hung Lin, Alice Chou
Publikováno v:
Journal of Biological Chemistry. 281:24111-24123
The polysaccharides of Ganoderma lucidum (Reishi) possess immunomodulation activities; however, their mode of molecular action in regulating each cellular subset in the immune system is still not clear. Here, we investigate the function of the main p
Autor:
Shu-Lin Chang, Da-Yung Chuang, Hui-Kai Kuo, Cicero Lee-Tian Chang, Yi-Ming Chiang, Wen-Chin Yang, Yi-Mei Lee
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(11)
Some polyacetylenes from the plant Bidens pilosa have been reported to treat diabetes. In this study, we report that the cytopiloyne from B. pilosa, which is structurally different from the above-mentioned polyacetylenes and inhibits CD4+ T cell prol